Gene: Pck1 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Pck1 |
NCBI Gene ID |
: |
18534 |
Species |
: |
Mus musculus |
Gene Synonyms |
: |
Pck-1 | Pck1 | PEPCK | Pepck | PEPCK-C | phosphoenolpyruvate carboxykinase 1, cytosolic | phosphoenolpyruvate carboxykinase, cytosolic | phosphoenolpyruvate carboxykinase, cytosolic [GTP] | phosphoenolpyruvate carboxylase | RP23-44L6.3
Source: GPSDB |
Gene Homologs |
: |
CG10924 (Drosophila melanogaster) | PCK1 (Bos taurus) | PCK1 (Canis lupus familiaris) | pck1 (Danio rerio) | PCK1 (Gallus gallus) | PCK1 (Homo sapiens) | PCK1 (Macaca mulatta) | Pck1 (Mus musculus) | PCK1 (Pan troglodytes) | Pck1 (Rattus norvegicus) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_001585 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005700 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Pck1 |
18534 |
|
|
Overexpression in skeletal muscle results in an increased number of mitochondria and extended lifespan. Transgenic mice ate 60% more than controls but had half the body weight and 10% of the body fat. |
17716967 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_003919 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Pck1 |
Mus musculus |
18534 |
over-expression |
- |
unknown |
unknown |
|
|
|
increased |
33.00% |
|
|
|
|
|
|
|
Overexpression in skeletal muscle results in extended lifespan at least 33%. Other phenotypes: Also in an increased number of mitochondria. Transgenic mice ate 60% more than controls but had half the body weight and 10% of the body fat. |
Hakimi et al. |
2007 |
17716967 |
doi:10.1074/jbc.M706127200 |
Lifespan Observations Database (ID: 633) |
2 |
OB_005701 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Pck1 |
Mus musculus |
18534 |
Overexpression |
- |
wildtype |
yes |
|
|
|
increased |
|
|
|
|
unknown |
|
|
|
Overexpression in skeletal muscle results in an increased number of mitochondria and extended lifespan. Transgenic mice ate 60% more than controls but had half the body weight and 10% of the body fat. |
Hakimi et al. |
2007 |
17716967 |
doi:10.1074/jbc.M706127200 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_009382 |
|
2 |
The HomoloGene homology group 1944 contains 2 genes with experimental evidence for ageing relevance (PCK1 - Homo sapiens | Pck1 - Mus musculus) and 8 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 1944 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F, Nye CK, Cabrera ME, Hagen DR, Utter CB, Baghdy Y, Johnson DH, Wilson DL, Kirwan JP, Kalhan SC, Hanson RW:
Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse.
J Biol Chem. 2007; 282: 32844-55.
PubMed (ID: 17716967), doi:10.1074/jbc.M706127200
MeSH Terms: Cytosol/enzymology; Energy Metabolism; Gene Expression Regulation, Enzymologic; Muscle, Skeletal/enzymology; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism
Sources
Ageing-related Data Sources
Additional Data Sources