Gene: Pin1 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Gene Symbol | : | Pin1 | ||||||||||||
NCBI Gene ID | : | 23988 | ||||||||||||
Species | : | Mus musculus | ||||||||||||
Gene Synonyms | : | peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | peptidyl-prolyl cis-trans isomerase Pin1 | Pin1 | PPIase Pin1 | protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 | rotamase Pin1 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP004321 (Anopheles gambiae) | AGOS_ACL120W (Eremothecium gossypii) | dod (Drosophila melanogaster) | ESS1 (Saccharomyces cerevisiae) | KLLA0E16567g (Kluyveromyces lactis) | LOC100859153 (Gallus gallus) | MGG_07389 (Magnaporthe oryzae) | NCU08554 (Neurospora crassa) | Os04g0663800 (Oryza sativa) | PIN1 (Arabidopsis thaliana) | PIN1 (Bos taurus) | PIN1 (Canis lupus familiaris) | pin1 (Danio rerio) | PIN1 (Homo sapiens) | Pin1 (Mus musculus) | PIN1 (Pan troglodytes) | Pin1 (Rattus norvegicus) | pin1 (Schizosaccharomyces pombe) | Y110A2AL.13 (Caenorhabditis elegans) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_001654 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Mus musculus | Q9QUR7 (UniProtKB/Swiss-Prot) | PIN1_MOUSE (UniProtKB/Swiss-Prot) | Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation (By similarity). Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009480 | 1 | The HomoloGene homology group 4531 contains 1 gene with experimental evidence for ageing relevance (PIN1 - Homo sapiens) and 18 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 4531 |
Sequences
PIN1_MOUSE | Q9QUR7 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Mus musculus) from UniProtKB/Swiss-Prot Length: 165 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 PIN1_MOUSE 1 MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGGSTVGGSSKNGQGEPAKVRCSHLLVKHSQSRRPSSWRQEKITRSKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGPFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE 165
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot