Gene: HSPA9 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | HSPA9 | ||||||||||||||||
NCBI Gene ID | : | 3313 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | 75 kDa glucose-regulated protein | CSA | GLUCOSE-REGULATED PROTEIN, 75-KD | GRP-75 | GRP75 | heat shock 70kD protein 9B | heat shock 70kDa protein 9 (mortalin) | heat shock 70kDa protein 9B (mortalin-2) | HEAT-SHOCK 70-KD PROTEIN 9 | HSPA9 | HSPA9B | MORTALIN | MORTALIN 2 | MORTALIN, PERINUCLEAR | mortalin, perinuclear | mortalin-2 | MOT | mot-2 | MOT2 | MTHSP75 | mthsp75 | p66-mortalin | PBP74 | peptide-binding protein 74 | stress-70 protein, mitochondrial Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP010876 (Anopheles gambiae) | AGOS_AFR352C (Eremothecium gossypii) | Hsc70-5 (Drosophila melanogaster) | hsp-6 (Caenorhabditis elegans) | HSP70-10 (Arabidopsis thaliana) | HSPA9 (Bos taurus) | HSPA9 (Canis lupus familiaris) | hspa9 (Danio rerio) | HSPA9 (Gallus gallus) | HSPA9 (Homo sapiens) | HSPA9 (Macaca mulatta) | Hspa9 (Mus musculus) | HSPA9 (Pan troglodytes) | Hspa9 (Rattus norvegicus) | KLLA0E22309g (Kluyveromyces lactis) | MGG_04191 (Magnaporthe oryzae) | NCU08693 (Neurospora crassa) | Os02g0774300 (Oryza sativa) | Os03g0113700 (Oryza sativa) | SSC1 (Saccharomyces cerevisiae) | ssc1 (Schizosaccharomyces pombe) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_001729 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Stress-70 protein, mitochondrial | Homo sapiens | P38646 (UniProtKB/Swiss-Prot) | GRP75_HUMAN (UniProtKB/Swiss-Prot) | Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009639 | Homo sapiens |
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HSPA9 appears to be involved in apoptosis and maybe cellular proliferation. It could also be a molecular chaperone. Roundworms with extra copies of Hsp70F, a HSPA9 homologue, live about 40% longer than controls [0904]. A role for HSPA9 in human ageing has not been established. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
GRP75_HUMAN | P38646 | Stress-70 protein, mitochondrial (Homo sapiens) from UniProtKB/Swiss-Prot Length: 679 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 GRP75_HUMAN 1 MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ 679
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Wadhwa R, Kaul SC, Sugimoto Y, Mitsui Y:
Spontaneous immortalization of mouse fibroblasts involves structural changes in senescence inducing protein, mortalin.
Biochem Biophys Res Commun. 1993; 197: 202-6.
PubMed (ID: 8250926), doi:10.1006/bbrc.1993.2461
MeSH Terms: Cell Aging/genetics; Genetic Variation; HSP70 Heat-Shock Proteins; Heat-Shock Proteins/genetics; Mice, Inbred Strains/genetics - Kaula SC, Reddelb RR, Sugiharac T, Mitsuia Y, Wadhwac R:
Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2.
FEBS Lett. 2000; 474: 159-64.
PubMed (ID: 10838077)
MeSH Terms: Cell Aging; Fibroblasts/cytology; HSP70 Heat-Shock Proteins/metabolism; Tumor Suppressor Protein p53/antagonists & inhibitors; Tumor Suppressor Protein p53/metabolism - Yokoyama K, Fukumoto K, Murakami T, Harada S, Hosono R, Wadhwa R, Mitsui Y, Ohkuma S:
Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75.
FEBS Lett. 2002; 516: 53-7.
PubMed (ID: 11959102)
MeSH Terms: Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans/genetics; Genes, Helminth; HSP70 Heat-Shock Proteins/genetics; Longevity/genetics - Kaul SC, Yaguchi T, Taira K, Reddel RR, Wadhwa R:
Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts.
Exp Cell Res. 2003; 286: 96-101.
PubMed (ID: 12729798)
MeSH Terms: Cell Aging/physiology; Fibroblasts/physiology; HSP70 Heat-Shock Proteins/metabolism; Telomerase/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot