Gene: Orco - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Orco |
NCBI Gene ID |
: |
40650 |
Species |
: |
Drosophila melanogaster |
Gene Synonyms |
: |
83A.2 | 83b | A45 | CG10609 | CG10609-PA | CG10609-PB | Dmel_CG10609 | DmelCG10609 | DOR45 | DOR83b | Odorant receptor 83b | odorant receptor 83b | Odorant receptor co-receptor | odorant receptor co-receptor | olfactory co-receptor | Olfactory coreceptor | olfactory coreceptor | olfactory receptor co-receptor | OR49 | OR83B | OR83b | Or83b | or83b | Orco | Orco-PA | Orco-PB | vainsA
Source: GPSDB |
Gene Homologs |
: |
OR7_ANOGA (Anopheles gambiae) | Orco (Drosophila melanogaster) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenDR |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_001783 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
Odorant receptor coreceptor |
Drosophila melanogaster |
Q9VNB5 (UniProtKB/Swiss-Prot) |
OR83B_DROME (UniProtKB/Swiss-Prot) |
Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Snmp, Or67d and lush act in concert to capture fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA) molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. |
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005668 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Orco |
40650 |
|
|
Loss-of-function mutation resulted in olfactory defects, altered adult metabolism, enhanced stress resistance, and life-extension. Female Or83b2 mutant flies showed a 56% increase in median lifespan and a 30% increase in maximum lifespan. Males were also long-lived, though to a smaller degree and maximum lifespan was not extended. Heterozygous mutants of both sexes showed an intermediate longevity. Dietary restriction further extended lifespan. |
17272684 |
GenAge |
2 |
OB_008018 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Orco |
40650 |
|
Other Ageing Factor Name |
Dietary restriction |
|
Loss-of-function mutation in Or83b results in olfactory defects, altered adult metabolism, enhanced stress resistance, and life-extension. Fully fed female homozygous Or83b null mutants exhibit a 56% increase in median lifespan and a 30% increase in maximum lifespan. Males are also significantly longer-lived, though to a smaller degree and maximum lifespan is not extended. Heterozygous mutants of both sexes show an intermediate longevity. Lifespan of homozygous Or83b null mutants is further increased by DR, but the relative increase in median and mean longevity is significantly greater when mutants were maintained in well-fed conditions [ 17272684]. |
17272684 |
GenDR |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_005669 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Orco |
Drosophila melanogaster |
40650 |
Mutation |
- |
wildtype |
yes |
|
|
|
increased |
30.00% |
|
|
|
maximum |
|
|
female |
Loss-of-function mutation resulted in olfactory defects, altered adult metabolism, enhanced stress resistance, and life-extension. Female Or83b2 mutant flies showed a 56% increase in median lifespan and a 30% increase in maximum lifespan. Males were also long-lived, though to a smaller degree and maximum lifespan was not extended. Heterozygous mutants of both sexes showed an intermediate longevity. Dietary restriction further extended lifespan. |
Libert et al. |
2007 |
17272684 |
doi:10.1126/science.1136610 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_009471 |
|
1 |
The HomoloGene homology group 15321 contains 1 gene with experimental evidence for ageing relevance (Orco - Drosophila melanogaster) and 1 other gene. |
AgeFactDB Homology Analysis |
HomoloGene homology group 15321 |
Sequences
Sources
Ageing-related Data Sources
Additional Data Sources