Gene: SOD2 - Saccharomyces cerevisiae(see also ageing factor AF_008759,AF_009025 *)
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | SOD2 | ||||||||||||||||||||||||
NCBI Gene ID | : | 856399 * | ||||||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||||||
Gene Synonyms | : | SOD2 | Sod2p | superoxide dismutase SOD2 | YHR008C Source: GPSDB |
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Gene Homologs | : | KLLA0E03609g (Kluyveromyces lactis) | MGG_00212 (Magnaporthe oryzae) | MNSOD1 (Anopheles gambiae) | NCU09560 (Neurospora crassa) | Os05g0323900 (Oryza sativa) | sod-2 (Caenorhabditis elegans) | sod-3 (Caenorhabditis elegans) | SOD2 (Bos taurus) | SOD2 (Canis lupus familiaris) | sod2 (Danio rerio) | Sod2 (Drosophila melanogaster) | SOD2 (Gallus gallus) | SOD2 (Homo sapiens) | SOD2 (Macaca mulatta) | Sod2 (Mus musculus) | SOD2 (Pan troglodytes) | Sod2 (Rattus norvegicus) | SOD2 (Saccharomyces cerevisiae) | sod2 (Schizosaccharomyces pombe) | SODA (Arabidopsis thaliana) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_002007 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_005970 | Saccharomyces cerevisiae |
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increased | 30.00% | unknown | Overexpression of Sod1 and Sod2 extends survival by 30%. | Fabrizio et al. | 2003 | 12586694 | GenAge | ||||||||||||||||||||||||
2 | OB_004171 | Saccharomyces cerevisiae | BY4742 |
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increased | 10.00% | 26.1 | mean | 30 | ℃ | The sod2 deletion from the MATalpha haploid yeast orf deletion collection had a replicative life span that was not significantly different (p=0.1) from wild type BY4742 cells. | Kaeberlein et al. | 2005 | 15722108 | doi:10.1016/j.mad.2004.10.007 | Lifespan Observations Database (ID: 861) | |||||||||||||||||||
3 | OB_005972 | Saccharomyces cerevisiae |
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decreased | -50.00% | unknown | Mean chronological lifespan decreased in the a strain by more than 50% | Laschober et al. | 2010 | 20883526 | doi:10.1111/j.1474-9726.2010.00637.x | GenAge | |||||||||||||||||||||||
4 | OB_005971 | Saccharomyces cerevisiae |
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decreased | -72.00% | unknown | 72% replicative lifespan decrease | Unlu et al. | 2007 | 17460215 | doi:10.1196/annals.1395.055 | GenAge | |||||||||||||||||||||||
5 | OB_000324 | Saccharomyces cerevisiae | EG103 |
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increased | Overexpression of SOD2 in combination with overexpression of SOD1 increases stationary phase survival by 30%. Other phenotypes: Deletion of SOD2 decreases survival in stationary phase [ 8647826]. | Fabrizio et al. | 2003 | 12882320 | Lifespan Observations Database (ID: 151) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Fabrizio P, Liou LL, Moy VN, Diaspro A, Valentine JS, Gralla EB, Longo VD:
SOD2 functions downstream of Sch9 to extend longevity in yeast.
Genetics. 2003; 163: 35-46.
PubMed (ID: 12586694), PubMed Central (ID: PMC1462415)
MeSH Terms: Fungal Proteins; Protein Kinases/metabolism; Saccharomyces cerevisiae Proteins; Saccharomyces cerevisiae/metabolism; Superoxide Dismutase/metabolism - Fabrizio P, Longo VD:
The chronological life span of Saccharomyces cerevisiae.
Aging Cell. 2003; 2: 73-81.
PubMed (ID: 12882320)
MeSH Terms: Saccharomyces cerevisiae/cytology - Kaeberlein M, Kirkland KT, Fields S, Kennedy BK:
Genes determining yeast replicative life span in a long-lived genetic background.
Mech Ageing Dev. 2005; 126: 491-504.
PubMed (ID: 15722108), doi:10.1016/j.mad.2004.10.007
MeSH Terms: Cell Aging/genetics; Gene Expression Regulation, Fungal/genetics; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae/genetics - Unlu ES, Koc A:
Effects of deleting mitochondrial antioxidant genes on life span.
Ann N Y Acad Sci. 2007; 1100: 505-9.
PubMed (ID: 17460215), doi:10.1196/annals.1395.055
MeSH Terms: Antioxidants/metabolism; Gene Deletion; Gene Expression Regulation, Fungal; Genes, Mitochondrial; Mitochondria/metabolism - Laschober GT, Ruli D, Hofer E, Muck C, Carmona-Gutierrez D, Ring J, Hutter E, Ruckenstuhl C, Micutkova L, Brunauer R, Jamnig A, Trimmel D, Herndler-Brandstetter D, Brunner S, Zenzmaier C, Sampson N, Breitenbach M, Fröhlich KU, Grubeck-Loebenstein B, Berger P, Wieser M, Grillari-Voglauer R, Thallinger GG, Grillari J, Trajanoski Z, Madeo F, Lepperdinger G, Jansen-Dürr P:
Identification of evolutionarily conserved genetic regulators of cellular aging.
Aging Cell. 2010; 9: 1084-97.
PubMed (ID: 20883526), PubMed Central (ID: PMC2997327), doi:10.1111/j.1474-9726.2010.00637.x
MeSH Terms: Cell Aging/genetics; Evolution, Molecular; Gene Expression Regulation
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed