Gene: FGF23 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | FGF23 | ||||||||||||||||
NCBI Gene ID | : | 8074 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | ADHR | FGF-23 | FGF23 | FIBROBLAST GROWTH FACTOR 23 | fibroblast growth factor 23 | HPDR2 | HYPF | phosphatonin | PHPTC | tumor-derived hypophosphatemia inducing factor | tumor-derived hypophosphatemia-inducing factor | UNQ3027/PRO9828 Source: GPSDB |
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Gene Homologs | : | FGF23 (Bos taurus) | FGF23 (Canis lupus familiaris) | fgf23 (Danio rerio) | FGF23 (Gallus gallus) | FGF23 (Homo sapiens) | FGF23 (Macaca mulatta) | Fgf23 (Mus musculus) | FGF23 (Pan troglodytes) | Fgf23 (Rattus norvegicus) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_002972 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Fibroblast growth factor 23 | Homo sapiens | Q9GZV9 (UniProtKB/Swiss-Prot) | FGF23_HUMAN (UniProtKB/Swiss-Prot) | Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_009880 | Homo sapiens |
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FGF23-null mice have a short lifespan and develop features resembling premature ageing. This appears to be a vitamin D-mediated process similar to that observed in klohto (KL) mice [1853]. KL has been shown to be an essential cofactor for activation of FGF signaling by FGF23 [1851]. Though inconclusive at present, FGF23 might play some role in ageing. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | ||||||||||||||||||||||||||||||
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1 | OB_008197 |
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2 | The HomoloGene homology group 10771 contains 2 genes with experimental evidence for ageing relevance (FGF23 - Homo sapiens | Fgf23 - Mus musculus) and 7 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 10771 |
Sequences
FGF23_HUMAN | Q9GZV9 | Fibroblast growth factor 23 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 251 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 FGF23_HUMAN 1 MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGGTGPEGCRPFAKFI 251
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- :
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23.
Nat Genet. 2000; 26: 345-8.
PubMed (ID: 11062477), doi:10.1038/81664
MeSH Terms: Chromosomes, Human, Pair 12/genetics; Fibroblast Growth Factors/genetics; Genes; Genes, Dominant; Hypophosphatemia, Familial/genetics - Shimada T, Kakitani M, Yamazaki Y, Hasegawa H, Takeuchi Y, Fujita T, Fukumoto S, Tomizuka K, Yamashita T:
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.
J Clin Invest. 2004; 113: 561-8.
PubMed (ID: 14966565), PubMed Central (ID: PMC338262), doi:10.1172/JCI19081
MeSH Terms: Fibroblast Growth Factors/metabolism; Phosphates/blood; Vitamin D/blood - Chefetz I, Heller R, Galli-Tsinopoulou A, Richard G, Wollnik B, Indelman M, Koerber F, Topaz O, Bergman R, Sprecher E, Schoenau E:
A novel homozygous missense mutation in FGF23 causes Familial Tumoral Calcinosis associated with disseminated visceral calcification.
Hum Genet. 2005; 118: 261-6.
PubMed (ID: 16151858), doi:10.1007/s00439-005-0026-8
MeSH Terms: Amino Acid Substitution; Calcinosis/genetics; Fibroblast Growth Factors/genetics; Mutation, Missense; Skin Neoplasms/genetics - Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, Baum MG, Schiavi S, Hu MC, Moe OW, Kuro-o M:
Regulation of fibroblast growth factor-23 signaling by klotho.
J Biol Chem. 2006; 281: 6120-3.
PubMed (ID: 16436388), PubMed Central (ID: PMC2637204), doi:10.1074/jbc.C500457200
MeSH Terms: Fibroblast Growth Factors/metabolism; Glucuronidase/physiology; Signal Transduction/physiology - Razzaque MS, Sitara D, Taguchi T, St-Arnaud R, Lanske B:
Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process.
FASEB J. 2006; 20: 720-2.
PubMed (ID: 16436465), PubMed Central (ID: PMC2899884), doi:10.1096/fj.05-5432fje
MeSH Terms: Aging, Premature/metabolism; Fibroblast Growth Factors/deficiency; Fibroblast Growth Factors/metabolism; Vitamin D/metabolism - Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T:
Klotho converts canonical FGF receptor into a specific receptor for FGF23.
Nature. 2006; 444: 770-4.
PubMed (ID: 17086194), doi:10.1038/nature05315
MeSH Terms: Fibroblast Growth Factors/metabolism; Glucuronidase/metabolism; Receptors, Fibroblast Growth Factor/metabolism; Signal Transduction - Medici D, Razzaque MS, Deluca S, Rector TL, Hou B, Kang K, Goetz R, Mohammadi M, Kuro-O M, Olsen BR, Lanske B:
FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis.
J Cell Biol. 2008; 182: 459-65.
PubMed (ID: 18678710), PubMed Central (ID: PMC2500132), doi:10.1083/jcb.200803024
MeSH Terms: Apoptosis/drug effects; Fibroblast Growth Factors/metabolism; Glucuronidase/metabolism; Vitamin D/pharmacology - Wolf I, Levanon-Cohen S, Bose S, Ligumsky H, Sredni B, Kanety H, Kuro-o M, Karlan B, Kaufman B, Koeffler HP, Rubinek T:
Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer.
Oncogene. 2008; 27: 7094-105.
PubMed (ID: 18762812), doi:10.1038/onc.2008.292
MeSH Terms: Breast Neoplasms/metabolism; Fibroblast Growth Factors/metabolism; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glucuronidase/physiology; Insulin-Like Growth Factor I/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot