Gene: AERO1 - Arabidopsis thaliana
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | AERO1 | ||||||||||||
NCBI Gene ID | : | 843560 | ||||||||||||
Species | : | Arabidopsis thaliana | ||||||||||||
Gene Synonyms | : | AERO1 | AT1G72280 | At1g72280 | AT1G72280.1 | endoplasmic oxidoreductin-1 | ENDOPLASMIC RETICULUM OXIDOREDUCTINS 1 | endoplasmic reticulum oxidoreductins 1 | ERO1 | T9N14.18 | T9N14_18 Source: GPSDB |
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Gene Homologs | : | AERO1 (Arabidopsis thaliana) | AERO2 (Arabidopsis thaliana) | AGOS_ADL348W (Eremothecium gossypii) | ero-1 (Caenorhabditis elegans) | ERO1 (Saccharomyces cerevisiae) | ero12 (Schizosaccharomyces pombe) | ERO1L (Bos taurus) | ERO1L (Canis lupus familiaris) | ero1l (Danio rerio) | ERO1L (Gallus gallus) | ERO1L (Homo sapiens) | ERO1L (Macaca mulatta) | Ero1l (Mus musculus) | ERO1L (Pan troglodytes) | Ero1l (Rattus norvegicus) | KLLA0D10241g (Kluyveromyces lactis) | MGG_00683 (Magnaporthe oryzae) | NCU02074 (Neurospora crassa) | Os03g0733800 (Oryza sativa) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_003005 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Endoplasmic oxidoreductin-1 | Arabidopsis thaliana | Q9C7S7 (UniProtKB/Swiss-Prot) | ERO1_ARATH (UniProtKB/Swiss-Prot) | Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI to transfer oxidizing equivalent. Does not oxidize all PDI related proteins, suggesting that it can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. | View |
Like disulfide bond formation protein | Arabidopsis thaliana | Q0WSW0 (UniProtKB/TrEMBL) | Q0WSW0_ARATH (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009068 | 1 | The HomoloGene homology group 49392 contains 1 gene with experimental evidence for ageing relevance (ero-1 - Caenorhabditis elegans) and 18 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 49392 |
Sequences
ERO1_ARATH | Q9C7S7 | Endoplasmic oxidoreductin-1 (Arabidopsis thaliana) from UniProtKB/Swiss-Prot Length: 469 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 ERO1_ARATH 1 MGKGAIKEEESEKKRKTWRWPLATLVVVFLAVAVSSRTNSNVGFFFSDRNSCSCSLQKTGKYKGMIEDCCCDYETVDNLNTEVLNPLLQDLVTTPFFRYYKVKLWCDCPFWPDDGMCRLRDCSVCECPENEFPEPFKKPFVPGLPSDDLKCQEGKPQGAVDRTIDNRAFRGWVETKNPWTHDDDTDSGEMSYVNLQLNPERYTGYTGPSARRIWDSIYSENCPKYSSGETCPEKKVLYKLISGLHSSISMHIAADYLLDESRNQWGQNIELMYDRILRHPDRVRNMYFTYLFVLRAVTKATAYLEQAEYDTGNHAEDLKTQSLIKQLLYSPKLQTACPVPFDEAKLWQGQSGPELKQQIQKQFRNISALMDCVGCEKCRLWGKLQVQGLGTALKILFSVGNQDIGDQTLQLQRNEVIALVNLLNRLSESVKMVHDMSPDVERLMEDQIAKVSAKPARLRRIWDLAVSFW 469
Q0WSW0_ARATH | Q0WSW0 | Like disulfide bond formation protein (Arabidopsis thaliana) from UniProtKB/TrEMBL Length: 469 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 Q0WSW0_ARATH 1 MGKGAIKEEESEKKRKTWRWPLATLVVVFLAVAVSSRTNSNVGFFFSDRNSCSCSLQKTGKYKGMIEDCCCDYETVDNLNTEVLNPLLQDLVTTPFFRYYKVKLWCDCPFWPDDGMCRLRDCSVCECPENEFPEPFKKPFVPGLPSDDLKCQEGKPQGAVDRTIDNRAFRGWVETKNPWTHDDDTDSGEMSYVNLQLNPERYTGYTGPSARRIWDSIYSENCPKYSSGETCPEKKVLYKLISGLHSSISMHIAADYLLDESRNQWGQNIELMYDRILRHPDRVRNMYFTYLFVLRAVTKATAYLEQAEYDTGNHAEDLKTQSLIKQLLYSPKLQTACPVPFDEAKLWQGQSGPELKQQIQKQFRNISALMDCVGCEKCRLWGKLQVQGLGTALKILFSVGNQDIGDQTLQLQRNEVIALVNLLNRLSESVKMVHDMSPDVERLMEDQIAKVSAKPARLRRIWDLAVSFW 469
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL