Gene: alpha-Man-I - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
alpha-Man-I |
NCBI Gene ID |
: |
31957 |
Species |
: |
Drosophila melanogaster |
Gene Synonyms |
: |
alpha 1,2 mannosidase | alpha Mannosidase I | alpha mannosidase I | alpha-1,2-mannosidase I | alpha-D-mannosidase | ALPHA-MAN-1 | alpha-Man-I | alpha-Man-I-PH | alpha-Man-I-PI | alpha-Man-I-PJ | alpha-Man-I-PK | alpha-Man-I-PL | alpha-Man-I-PM | alpha-Man-I-PN | alpha-Man-I-PO | alpha-Man-I-PP | alpha-Man-l | alpha-mannosidase | CG17809 | CG18799 | CG32682 | CG32684 | CG42275 | CG42275-PH | CG42275-PI | CG42275-PJ | CG42275-PK | CG42275-PL | CG42275-PM | CG42275-PN | CG42275-PO | CG42275-PP | DM-GI | Dmel_CG32682 | Dmel_CG32684 | Dmel_CG42275 | DmelCG42275 | MA12 | Man'ase | MAN-1 | Mannosidase 1 | mannosidase 1 | mas-1 | mas1
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP000558 (Anopheles gambiae) | alpha-Man-I (Drosophila melanogaster) | D2030.1 (Caenorhabditis elegans) | MAN1A2 (Bos taurus) | MAN1A2 (Canis lupus familiaris) | MAN1A2 (Gallus gallus) | MAN1A2 (Homo sapiens) | MAN1A2 (Macaca mulatta) | Man1a2 (Mus musculus) | MAN1A2 (Pan troglodytes) | Man1a2 (Rattus norvegicus) | MGG_11475 (Magnaporthe oryzae) | NCU02235 (Neurospora crassa) | wu:fj20e02 (Danio rerio) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_003101 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_006334 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
alpha-Man-I |
31957 |
|
|
Mutant flies showed enhanced resistance to paraquat and starvation and a 60% increase in mean lifespan for both sexes. After outcrossing, the mutant showed, under normal conditions, an increase in mean lifespan of 22% for females and 38% for males . The increase in maximum lifespan was 15%. RNAi knock-downs resulted in a 39% increase in mean lifespan. |
19302370 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_006335 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
alpha-Man-I |
Drosophila melanogaster |
31957 |
RNA interference, Mutations |
- |
wildtype |
yes |
|
|
|
increased |
15.00% |
|
|
|
maximum |
|
|
female |
Mutant flies showed enhanced resistance to paraquat and starvation and a 60% increase in mean lifespan for both sexes. After outcrossing, the mutant showed, under normal conditions, an increase in mean lifespan of 22% for females and 38% for males . The increase in maximum lifespan was 15%. RNAi knock-downs resulted in a 39% increase in mean lifespan. |
Liu et al. |
2009 |
19302370 |
doi:10.1111/j.1474-9726.2009.00471.x |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008167 |
|
2 |
The HomoloGene homology group 55982 contains 2 genes with experimental evidence for ageing relevance (D2030.1 - Caenorhabditis elegans | alpha-Man-I - Drosophila melanogaster) and 12 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 55982 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Liu YL, Lu WC, Brummel TJ, Yuh CH, Lin PT, Kao TY, Li FY, Liao PC, Benzer S, Wang HD:
Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans.
Aging Cell. 2009; 8: 370-9.
PubMed (ID: 19302370), doi:10.1111/j.1474-9726.2009.00471.x
MeSH Terms: Caenorhabditis elegans/enzymology; Drosophila melanogaster/enzymology; Longevity; Mannosidases/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources