Gene: MED1 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | MED1 | ||||||||||||||||
NCBI Gene ID | : | 5469 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | activator-recruited cofactor 205 kDa component | ARC205 | COFACTOR REQUIRED FOR SP1 TRANSCRIPTIONAL ACTIVATION, SUBUNIT 1 | CRSP, 200-KD SUBUNIT | CRSP1 | CRSP200 | DRIP205 | DRIP230 | MED1 | MEDIATOR COMPLEX SUBUNIT 1 | mediator complex subunit 1 | mediator of RNA polymerase II transcription subunit 1 | p53 regulatory protein RB18A | PBP | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-BINDING PROTEIN | peroxisome proliferator-activated receptor-binding protein | PPAR binding protein | PPAR-BINDING PROTEIN | PPAR-binding protein | PPARBP | PPARG binding protein | PPARGBP | RB18A | RECOGNIZED BY PAb1801 MONOCLONAL ANTIBODY | THYROID HORMONE RECEPTOR INTERACTOR 2 | thyroid hormone receptor-associated protein complex 220 kDa component | thyroid hormone receptor-associated protein complex component TRAP220 | thyroid receptor interacting protein 2 | thyroid receptor-interacting protein 2 | TR-interacting protein 2 | TRAP220 | TRIP-2 | TRIP2 | vitamin D receptor-interacting protein 230 kD | vitamin D receptor-interacting protein complex component DRIP205 | VITAMIN D RECEPTOR-INTERACTING PROTEIN, 205-KD | VITAMIN D RECEPTOR-INTERACTING PROTEIN, 230-KD Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP012219 (Anopheles gambiae) | MED1 (Bos taurus) | MED1 (Canis lupus familiaris) | med1 (Danio rerio) | MED1 (Drosophila melanogaster) | MED1 (Gallus gallus) | MED1 (Homo sapiens) | Med1 (Mus musculus) | MED1 (Pan troglodytes) | Med1 (Rattus norvegicus) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_003237 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Mediator of RNA polymerase II transcription subunit 1 | Homo sapiens | Q15648 (UniProtKB/Swiss-Prot) | MED1_HUMAN (UniProtKB/Swiss-Prot) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_009677 | Homo sapiens |
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MED1 is a transcriptional coactivator involved in embryonic development and important for SP1 activity [0785]. MED1-null mice die at embryonic stages [0785]. Certain age-related pathologies, such as heart disease, may be related to PPARs [0392], but it unclear whether MED1 is a major player in human ageing. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008211 | 1 | The HomoloGene homology group 21002 contains 1 gene with experimental evidence for ageing relevance (MED1 - Homo sapiens) and 9 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 21002 |
Sequences
MED1_HUMAN | Q15648 | Mediator of RNA polymerase II transcription subunit 1 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 1581 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 1570 1580 MED1_HUMAN 1 MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN 1581
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kersten S, Desvergne B, Wahli W:
Roles of PPARs in health and disease.
Nature. 2000; 405: 421-4.
PubMed (ID: 10839530), doi:10.1038/35013000
MeSH Terms: Receptors, Cytoplasmic and Nuclear/physiology; Transcription Factors/physiology - Ito M, Yuan CX, Okano HJ, Darnell RB, Roeder RG:
Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action.
Mol Cell. 2000; 5: 683-93.
PubMed (ID: 10882104)
MeSH Terms: Carrier Proteins/metabolism; Pituitary Gland/embryology; Receptors, Thyroid Hormone/metabolism; Thyroid Gland/embryology; Thyroid Hormones/metabolism; Transcription Factors
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot