Gene: EGR1 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | EGR1 | ||||||||||||||||
NCBI Gene ID | : | 1958 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | AT225 | EARLY GROWTH RESPONSE 1 | early growth response 1 | early growth response protein 1 | EGR-1 | EGR1 | G0S30 | KROX-24 | KROX24 | NERVE GROWTH FACTOR-INDUCED CLONE A | nerve growth factor-induced protein A | NGFI-A | NGFIA | TIS8 | transcription factor ETR103 | transcription factor Zif268 | ZIF-268 | ZIF268 | zinc finger protein 225 | zinc finger protein Krox-24 | ZNF225 Source: GPSDB |
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Gene Homologs | : | EGR1 (Bos taurus) | EGR1 (Canis lupus familiaris) | egr1 (Danio rerio) | EGR1 (Gallus gallus) | EGR1 (Homo sapiens) | EGR1 (Macaca mulatta) | Egr1 (Mus musculus) | EGR1 (Pan troglodytes) | Egr1 (Rattus norvegicus) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_003375 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Early growth response protein 1 | Homo sapiens | P18146 (UniProtKB/Swiss-Prot) | EGR1_HUMAN (UniProtKB/Swiss-Prot) | Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. | View |
Early growth response 1, isoform CRA_a | Homo sapiens | Q546S1 (UniProtKB/TrEMBL) | Q546S1_HUMAN (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009861 | Homo sapiens |
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An important regulator of the cell cycle, EGR1 has been suggested to act upstream of ageing-related genes such as TP53 [0163]. It also appears to be pro-apoptotic [0466]. EGR1's role in ageing is unknown, but it might be part of its signalling cascade. Further studies are necessary to establish whether EGR1 is a factor in human ageing. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | ||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_008937 |
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1 | The HomoloGene homology group 56394 contains 1 gene with experimental evidence for ageing relevance (EGR1 - Homo sapiens) and 8 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 56394 |
Sequences
EGR1_HUMAN | P18146 | Early growth response protein 1 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 543 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 EGR1_HUMAN 1 MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGAPEGSGSNSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDISLNNEKVLVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAASSASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSGSQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSSTYPSPVHSGFPSPSVATTYSSVPPAFPAQVSSFPSSAVTNSFSASTGLSDMTATFSPRTIEIC 543
Q546S1_HUMAN | Q546S1 | Early growth response 1, isoform CRA_a (Homo sapiens) from UniProtKB/TrEMBL Length: 543 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 Q546S1_HUMAN 1 MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGAPEGSGSNSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDISLNNEKVLVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAASSASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSGSQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSSTYPSPVHSGFPSPSVATTYSSVPPAFPAQVSSFPSSAVTNSFSASTGLSDMTATFSPRTIEIC 543
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Sukhatme VP, Cao XM, Chang LC, Tsai-Morris CH, Stamenkovich D, Ferreira PC, Cohen DR, Edwards SA, Shows TB, Curran T:
A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization.
Cell. 1988; 53: 37-43.
PubMed (ID: 3127059)
MeSH Terms: DNA-Binding Proteins/genetics; Genes; Genes, Regulator; Metalloproteins/genetics; Proto-Oncogenes - Lee SL, Sadovsky Y, Swirnoff AH, Polish JA, Goda P, Gavrilina G, Milbrandt J:
Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1).
Science. 1996; 273: 1219-21.
PubMed (ID: 8703054)
MeSH Terms: DNA-Binding Proteins/genetics; Gene Expression Regulation; Immediate-Early Proteins; Infertility, Female/genetics; Luteinizing Hormone/deficiency; Luteinizing Hormone/genetics; Transcription Factors/genetics - Liu C, Rangnekar VM, Adamson E, Mercola D:
Suppression of growth and transformation and induction of apoptosis by EGR-1.
Cancer Gene Ther. 1998; 5: 3-28.
PubMed (ID: 9476963)
MeSH Terms: Apoptosis; Cell Transformation, Neoplastic; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Immediate-Early Proteins; Transcription Factors/genetics; Transcription Factors/physiology - Das A, Chendil D, Dey S, Mohiuddin M, Mohiuddin M, Milbrandt J, Rangnekar VM, Ahmed MM:
Ionizing radiation down-regulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis.
J Biol Chem. 2001; 276: 3279-86.
PubMed (ID: 11035041), doi:10.1074/jbc.M008454200
MeSH Terms: Adaptor Proteins, Signal Transducing; Apoptosis; DNA-Binding Proteins/metabolism; Fibroblasts/metabolism; Immediate-Early Proteins; Nuclear Proteins; Transcription Factors/metabolism; Tumor Suppressor Protein p53/metabolism - Krones-Herzig A, Adamson E, Mercola D:
Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence.
Proc Natl Acad Sci USA. 2003; 100: 3233-8.
PubMed (ID: 12629205), PubMed Central (ID: PMC152275), doi:10.1073/pnas.2628034100
MeSH Terms: DNA-Binding Proteins/physiology; Immediate-Early Proteins; Transcription Factors/physiology; Tumor Suppressor Protein p53/physiology
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL