Gene: jnk-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | jnk-1 | ||||||||||||||||||||||||||||||||
NCBI Gene ID | : | 177460 | ||||||||||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||||||||||
Gene Synonyms | : | B0478.1 | B0478.1a | B0478.1b | B0478.1b.1 | B0478.1b.2 | B0478.1b.3 | CE27574 | CE30123 | CELE_B0478.1 | jnk-1 | Protein JNK-1 | sak-1 | WP:CE27574 | WP:CE30123 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP009461 (Anopheles gambiae) | bsk (Drosophila melanogaster) | jnk-1 (Caenorhabditis elegans) | MAPK8 (Bos taurus) | MAPK8 (Canis lupus familiaris) | MAPK8 (Gallus gallus) | MAPK8 (Homo sapiens) | MAPK8 (Macaca mulatta) | Mapk8 (Mus musculus) | MAPK8 (Pan troglodytes) | Mapk8 (Rattus norvegicus) | mapk8a (Danio rerio) | ||||||||||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_003968 | ||||||||||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Stress-activated protein kinase jnk-1 | Caenorhabditis elegans | Q8WQG9 (UniProtKB/Swiss-Prot) | JNK1_CAEEL (UniProtKB/Swiss-Prot) | Responds to activation by environmental stress by phosphorylating a number of transcription factors, and thus regulates transcriptional activity (By similarity). May coordinate locomotion by acting via type-D GABAergic motor neurons and regulate synaptic vesicle transport in conjunction with unc-16. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_005454 | Caenorhabditis elegans |
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Mutant worms have a 30% shortened maximal lifespan. | 18832074 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | |||||||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | |||||||||||||||||||||||||
1 | OB_005453 | Caenorhabditis elegans |
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increased | 40.00% | unknown | Overexpression increases lifespan by 40%. | Oh et al. | 2005 | 15767565 | doi:10.1073/pnas.0500749102 | GenAge | ||||||||||||||||||||||||||||||||||
2 | OB_003839 | Caenorhabditis elegans | N2 |
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increased | 37.50% | 20.9 | 15.2 | days | mean | 20 | ℃ | hermaphrodite | Overexpression of jnk-1(lpln1) increases lifespan by 40%. | Oh et al. | 2005 | 15767565 | doi:10.1073/pnas.0500749102 | Lifespan Observations Database (ID: 561) | |||||||||||||||||||||||||||
3 | OB_003419 | Caenorhabditis elegans | N2 |
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none | 2.62% | 117.3 | 114.3 | mean | 25 | ℃ | There was no significant difference in lifespan of jnk-1(km2) mutant than N2 control on cdc-25.1 background. | Evans et al. | 2008 | 18782349 | doi:10.1111/j.1474-9726.2008.00435.x | Lifespan Observations Database (ID: 4844) | ||||||||||||||||||||||||||||
4 | OB_003418 | Caenorhabditis elegans | N2 |
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none | 0.17% | 114.5 | 114.3 | mean | 25 | ℃ | There was no significant difference in lifespan of jnk-1(gk7) mutant than N2 control on cdc-25.1 background. | Evans et al. | 2008 | 18782349 | doi:10.1111/j.1474-9726.2008.00435.x | Lifespan Observations Database (ID: 4843) | ||||||||||||||||||||||||||||
5 | OB_002981 | Caenorhabditis elegans | N2 |
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decreased | -7.45% | 15.65 | 16.91 | days | mean | 20 | ℃ | hermaphrodite | The flavanol catechin extended life span in C. elegans. | Saul et al. | 2009 | 19501612 | doi:10.1016/j.mad.2009.05.005 | Lifespan Observations Database (ID: 4316) | ||||||||||||||||||||||||||
6 | OB_002980 | Caenorhabditis elegans | N2 |
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decreased | -12.30% | 14.83 | 16.91 | days | mean | 20 | ℃ | hermaphrodite | The flavanol catechin extended life span in C. elegans. | Saul et al. | 2009 | 19501612 | doi:10.1016/j.mad.2009.05.005 | Lifespan Observations Database (ID: 4315) | |||||||||||||||||||||||||||
7 | OB_002316 | Caenorhabditis elegans | N2 |
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decreased | -17.61% | 14.5 | 17.6 | days | mean | 20 | ℃ | hermaphrodite | RNAi knockdown results in 17% decreased lifespan. | Oh et al. | 2005 | 15767565 | doi:10.1073/pnas.0500749102 | Lifespan Observations Database (ID: 3591) | |||||||||||||||||||||||||||
8 | OB_002312 | Caenorhabditis elegans | N2 |
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decreased | -17.86% | 13.8 | 16.8 | days | mean | 20 | ℃ | hermaphrodite | Mutation results in 18% decreased lifespan. | Oh et al. | 2005 | 15767565 | doi:10.1073/pnas.0500749102 | Lifespan Observations Database (ID: 3588) | |||||||||||||||||||||||||||
9 | OB_005455 | Caenorhabditis elegans |
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decreased | -30.00% | maximum | Mutant worms have a 30% shortened maximal lifespan. | Neumann-Haefelin et al. | 2008 | 18832074 | doi:10.1101/gad.478408 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
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1 | OB_008870 | 3 | The HomoloGene homology group 56760 contains 3 genes with experimental evidence for ageing relevance (MAPK8 - Homo sapiens | bsk - Drosophila melanogaster | jnk-1 - Caenorhabditis elegans) and 9 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 56760 |
Sequences
JNK1_CAEEL | Q8WQG9 | Stress-activated protein kinase jnk-1 (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 463 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 JNK1_CAEEL 1 MEERLSTTSSYPSHPGRSVEEDHNTLLASSSISSIIRGTRGHLNNFIESVGNWLVPSSSGRDDDAVSLDSCQSVYSPVRHHINSGTGGGILMEPSSIHVPENYYSVTIGEAQMVVLKRYQNLRLIGSGAQGIVCSAFDTVRNEQVAIKKLSRPFQNVTHAKRAYRELKLMSLVNHKNIIGILNCFTPQKKLDEFNDLYIVMELMDANLCQVIQMDLDHERLSYLLYQMLCGIRHLHSAGIIHRDLKPSNIVVRSDCTLKILDFGLARTAIEAFMMTPYVVTRYYRAPEVILGMGYKENVDVWSIGCIFGELIRGRVLFPGGDHIDQWTRIIEQLGTPDRSFLERLQPTVRNYVENRPRYQATPFEVLFSDNMFPMTADSSRLTGAQARDLLSRMLVIDPERRISVDDALRHPYVNVWFDEIEVYAPPPLPYDHNMDVEQNVDSWREHIFRELTDYARTHDIYS 463
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA:
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
Proc Natl Acad Sci USA. 2005; 102: 4494-9.
PubMed (ID: 15767565), PubMed Central (ID: PMC555525), doi:10.1073/pnas.0500749102
MeSH Terms: Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Longevity/genetics; Longevity/physiology; Mitogen-Activated Protein Kinase 8/genetics; Mitogen-Activated Protein Kinase 8/physiology; Transcription Factors/genetics; Transcription Factors/physiology - Evans EA, Chen WC, Tan MW:
The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans.
Aging Cell. 2008; 7: 879-93.
PubMed (ID: 18782349), PubMed Central (ID: PMC2630471), doi:10.1111/j.1474-9726.2008.00435.x
MeSH Terms: Aging/immunology; Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/immunology; Immunity, Innate/genetics; Insulin/physiology; Receptor, Insulin/physiology; Signal Transduction/immunology - Neumann-Haefelin E, Qi W, Finkbeiner E, Walz G, Baumeister R, Hertweck M:
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.
Genes Dev. 2008; 22: 2721-35.
PubMed (ID: 18832074), PubMed Central (ID: PMC2559911), doi:10.1101/gad.478408
MeSH Terms: Adaptor Proteins, Signal Transducing/physiology; Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/physiology; Longevity/physiology - Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CE:
Catechin induced longevity in C. elegans: from key regulator genes to disposable soma.
Mech Ageing Dev. 2009; 130: 477-86.
PubMed (ID: 19501612), doi:10.1016/j.mad.2009.05.005
MeSH Terms: Catechin/metabolism; Longevity
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/Swiss-Prot
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed