Gene: Bax - Mus musculus(see also ageing factor AF_008881 *)
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
Apoptosis regulator BAX |
Mus musculus |
Q07813 (UniProtKB/Swiss-Prot) |
BAX_MOUSE (UniProtKB/Swiss-Prot) |
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production. |
View |
Bcl2-associated X protein, isoform CRA_b |
Mus musculus |
Q544Z6 (UniProtKB/TrEMBL) |
Q544Z6_MOUSE (UniProtKB/TrEMBL) |
|
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005488 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Bax |
12028 |
|
|
Inactivation extended fertile potential and minimized age-related health problems, including bone and muscle loss, excess fat deposition, alopecia, cataracts, deafness, increased anxiety, and selective attention deficit. It did not extend lifespan. |
17360389 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_005489 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Bax |
Mus musculus |
12028 |
Knockout |
- |
wildtype |
yes |
|
|
|
increased |
|
|
|
|
unknown |
|
|
|
Inactivation extended fertile potential and minimized age-related health problems, including bone and muscle loss, excess fat deposition, alopecia, cataracts, deafness, increased anxiety, and selective attention deficit. It did not extend lifespan. |
Perez et al. |
2007 |
17360389 |
doi:10.1073/pnas.0608557104 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008610 |
|
2 |
The HomoloGene homology group 7242 contains 2 genes with experimental evidence for ageing relevance (BAX - Homo sapiens | Bax - Mus musculus) and 7 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 7242 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Perez GI, Jurisicova A, Wise L, Lipina T, Kanisek M, Bechard A, Takai Y, Hunt P, Roder J, Grynpas M, Tilly JL:
Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice.
Proc Natl Acad Sci USA. 2007; 104: 5229-34.
PubMed (ID: 17360389), PubMed Central (ID: PMC1817832), doi:10.1073/pnas.0608557104
MeSH Terms: Aging/physiology; Fertility/physiology; bcl-2-Associated X Protein/deficiency
Sources
Ageing-related Data Sources
Additional Data Sources