1 |
OB_003879 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
MPT5 |
Saccharomyces cerevisiae |
852697 |
over-expression |
- |
unknown |
unknown |
|
|
|
increased |
25.00% |
|
|
|
|
|
|
|
Overexpression extended lifespan by about 25%. |
Kennedy et al. |
1997 |
9150138 |
|
Lifespan Observations Database (ID: 598) |
2 |
OB_005576 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
MPT5 |
Saccharomyces cerevisiae |
852697 |
Overexpression |
- |
wildtype |
yes |
|
|
|
increased |
25.00% |
|
|
|
unknown |
|
|
|
Overexpression extended lifespan by about 25%. |
Kennedy et al. |
1997 |
9150138 |
|
GenAge |
3 |
OB_005577 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
MPT5 |
Saccharomyces cerevisiae |
852697 |
Overexpression |
- |
wildtype |
yes |
|
|
|
increased |
20.00% |
|
|
|
unknown |
|
|
|
Overexpression of MPT5 extends replicative life span by about 20% |
Kaeberlein et al. |
2002 |
11805047 |
|
GenAge |
4 |
OB_004134 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
MPT5 |
Saccharomyces cerevisiae |
852697 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-36.00% |
|
28 |
|
mean |
30 |
℃ |
|
The mpt5 deletion from the MATalpha haploid yeast orf deletion collection had a shortened replicative life span relative to wild type BY4742 cells. |
Kaeberlein et al. |
2005 |
15722108 |
doi:10.1016/j.mad.2004.10.007 |
Lifespan Observations Database (ID: 828) |
5 |
OB_005579 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
MPT5 |
Saccharomyces cerevisiae |
852697 |
Deletion |
- |
wildtype |
yes |
|
|
|
decreased |
-50.00% |
|
|
|
unknown |
|
|
|
Average chronological lifespan decreased by 50%. Rescued to the wt level by PKC1 overexpression |
Stewart et al. |
2007 |
17172436 |
doi:10.1128/EC.00188-06 |
GenAge |
6 |
OB_000476 |
Saccharomyces cerevisiae |
W303, PSY316, PSY142 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
MPT5 |
Saccharomyces cerevisiae |
852697 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
|
|
|
|
|
|
|
|
Deletion of UTH4 shortens life-span by approximately 50%. Other phenotypes: Deletion of UTH4 shortens life-span by approximately 50% [ 9150138][ 11805047]. Overexpression of UTH4 from the ADH promoter extends life-span in PSY142 by about 25% [ 9150138] and extends life-span in W303R by about 20% [ 11805047]. UTH4 mutants are temperature sensitive [ 7845352] and hypersensitive to mating pheromone [ 9154842]. Null mutants also show increased silencing at telomeres and decreased rDNA silencing [ 9584615]. Deletion of MPT5 is synthetically lethal with mutation of either SWI4, SWI6 or CCR4 in an ssd1-d background [ 11805047]. Uth4p is required for relocalization of the SIR complex to the nucleolus in sir4-42 strain [ 9150138]. |
Kennedy et al. |
1997 |
9150138 |
|
Lifespan Observations Database (ID: 173) |
7 |
OB_000487 |
Saccharomyces cerevisiae |
W303, PSY316, PSY142 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
MPT5 |
Saccharomyces cerevisiae |
852697 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
|
|
|
|
|
|
|
|
Deletion of UTH4 shortens life-span by approximately 50%. Other phenotypes: Deletion of UTH4 shortens life-span by approximately 50% [ 9150138][ 11805047]. Overexpression of UTH4 from the ADH promoter extends life-span in PSY142 by about 25% [ 9150138] and extends life-span in W303R by about 20% [ 11805047]. UTH4 mutants are temperature sensitive [ 7845352] and hypersensitive to mating pheromone [ 9154842]. Null mutants also show increased silencing at telomeres and decreased rDNA silencing [ 9584615]. Deletion of MPT5 is synthetically lethal with mutation of either SWI4, SWI6 or CCR4 in an ssd1-d background [ 11805047]. Uth4p is required for relocalization of the SIR complex to the nucleolus in sir4-42 strain [ 9150138]. |
Kaeberlein et al. |
2002 |
11805047 |
|
Lifespan Observations Database (ID: 174) |
8 |
OB_000498 |
Saccharomyces cerevisiae |
W303, PSY316, PSY142 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
MPT5 |
Saccharomyces cerevisiae |
852697 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
|
|
|
|
|
|
|
|
Overexpression of UTH4 from the ADH promoter extends life-span in PSY142 by about 25%. Other phenotypes: Deletion of UTH4 shortens life-span by approximately 50% [ 9150138][ 11805047]. Overexpression of UTH4 from the ADH promoter extends life-span in PSY142 by about 25% [ 9150138] and extends life-span in W303R by about 20% [ 11805047]. UTH4 mutants are temperature sensitive [ 7845352] and hypersensitive to mating pheromone [ 9154842]. Null mutants also show increased silencing at telomeres and decreased rDNA silencing [ 9584615]. Deletion of MPT5 is synthetically lethal with mutation of either SWI4, SWI6 or CCR4 in an ssd1-d background [ 11805047]. Uth4p is required for relocalization of the SIR complex to the nucleolus in sir4-42 strain [ 9150138]. |
Kennedy et al. |
1997 |
9150138 |
|
Lifespan Observations Database (ID: 175) |
9 |
OB_000509 |
Saccharomyces cerevisiae |
W303, PSY316, PSY142 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
MPT5 |
Saccharomyces cerevisiae |
852697 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
|
|
|
|
|
|
|
|
Overexpression of UTH4 from the ADH promoter extends life-span in W303R by about 20% . Other phenotypes: Deletion of UTH4 shortens life-span by approximately 50% [ 9150138][ 11805047]. Overexpression of UTH4 from the ADH promoter extends life-span in PSY142 by about 25% [ 9150138] and extends life-span in W303R by about 20% [ 11805047]. UTH4 mutants are temperature sensitive [ 7845352] and hypersensitive to mating pheromone [ 9154842]. Null mutants also show increased silencing at telomeres and decreased rDNA silencing [ 9584615]. Deletion of MPT5 is synthetically lethal with mutation of either SWI4, SWI6 or CCR4 in an ssd1-d background [ 11805047]. Uth4p is required for relocalization of the SIR complex to the nucleolus in sir4-42 strain [ 9150138]. |
Kaeberlein et al. |
2002 |
11805047 |
|
Lifespan Observations Database (ID: 176) |