Gene: MCM2 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | MCM2 | ||||||||||||
NCBI Gene ID | : | 4171 | ||||||||||||
Species | : | Homo sapiens | ||||||||||||
Gene Synonyms | : | BM28 | CCNL1 | cdc19 | CDCL1 | cell devision cycle-like 1 | CELL DIVISION CYCLE-LIKE 1 | cyclin-like 1 | D3S3194 | DNA replication licensing factor MCM2 | KIAA0030 | MCM2 | MCM2 minichromosome maintenance deficient 2, mitotin | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) | minichromosome maintenance complex component 2 | minichromosome maintenance deficient (S. cerevisiae) 2 (mitotin) | minichromosome maintenance deficient 2 (mitotin) | minichromosome maintenance protein 2 homolog | MINICHROMOSOME MAINTENANCE, S. CEREVISIAE, HOMOLOG OF, 2 | MITOTIN | mitotin | NUCLEAR PROTEIN BM28 | nuclear protein BM28 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP004275 (Anopheles gambiae) | AGOS_AFR178W (Eremothecium gossypii) | AT1G44900.1 (Arabidopsis thaliana) | KLLA0F12584g (Kluyveromyces lactis) | mcm-2 (Caenorhabditis elegans) | MCM2 (Bos taurus) | MCM2 (Canis lupus familiaris) | mcm2 (Danio rerio) | Mcm2 (Drosophila melanogaster) | MCM2 (Gallus gallus) | MCM2 (Homo sapiens) | MCM2 (Macaca mulatta) | Mcm2 (Mus musculus) | MCM2 (Pan troglodytes) | Mcm2 (Rattus norvegicus) | MCM2 (Saccharomyces cerevisiae) | mcm2 (Schizosaccharomyces pombe) | MGG_08122 (Magnaporthe oryzae) | NCU04327 (Neurospora crassa) | Os11g0484300 (Oryza sativa) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_004055 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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DNA replication licensing factor MCM2 | Homo sapiens | P49736 (UniProtKB/Swiss-Prot) | MCM2_HUMAN (UniProtKB/Swiss-Prot) | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
MCM2_HUMAN | P49736 | DNA replication licensing factor MCM2 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 904 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 MCM2_HUMAN 1 MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMILQQF 904
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot