Gene: Mcm2 - Mus musculus(see also ageing factor AF_008909 *)
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Mcm2 | ||||||||||||||||
NCBI Gene ID | : | 17216 * | ||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||
Gene Synonyms | : | Possible synonym group : BM28 | Bm28 | CDCL1 | Cdcl1 | DNA replication licensing factor MCM2 | Kiaa0030 | Mcm2 | Mcmd2 | mini chromosome maintenance deficient 2 | minichromosome maintenance deficient 2 mitotin (S. cerevisiae) | minichromosome maintenance protein 2 homolog | mKIAA0030 | nuclear protein BM28 Source: GPSDB |
||||||||||||||||
Gene Homologs | : | AgaP_AGAP004275 (Anopheles gambiae) | AGOS_AFR178W (Eremothecium gossypii) | AT1G44900.1 (Arabidopsis thaliana) | KLLA0F12584g (Kluyveromyces lactis) | mcm-2 (Caenorhabditis elegans) | MCM2 (Bos taurus) | MCM2 (Canis lupus familiaris) | mcm2 (Danio rerio) | Mcm2 (Drosophila melanogaster) | MCM2 (Gallus gallus) | MCM2 (Homo sapiens) | MCM2 (Macaca mulatta) | Mcm2 (Mus musculus) | MCM2 (Pan troglodytes) | Mcm2 (Rattus norvegicus) | MCM2 (Saccharomyces cerevisiae) | mcm2 (Schizosaccharomyces pombe) | MGG_08122 (Magnaporthe oryzae) | NCU04327 (Neurospora crassa) | Os11g0484300 (Oryza sativa) | ||||||||||||||||
Ageing Relevance Analysis | : |
|
||||||||||||||||
Ageing Factor Stable ID | : | AF_004056 | ||||||||||||||||
Download | : | XML |
*
AgeFactDB contains further genes associated with gene symbol Mcm2 and the species Mus musculus: AF_008909
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
DNA replication licensing factor MCM2 | Mus musculus | P97310 (UniProtKB/Swiss-Prot) | MCM2_MOUSE (UniProtKB/Swiss-Prot) | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_005541 | Mus musculus |
|
Conditional knockouts with reduced expression develop normally but lifespan is greatly reduced with most animals living 10-12 weeks accompanied by deficiencies in the proliferative cell compartments of several tissues and increased cancer incidence. | 17717065 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_005542 | Mus musculus |
|
decreased | unknown | Conditional knockouts with reduced expression develop normally but lifespan is greatly reduced with most animals living 10-12 weeks accompanied by deficiencies in the proliferative cell compartments of several tissues and increased cancer incidence. | Pruitt et al. | 2007 | 17717065 | doi:10.1634/stemcells.2007-0483 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
MCM2_MOUSE | P97310 | DNA replication licensing factor MCM2 (Mus musculus) from UniProtKB/Swiss-Prot Length: 904 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 MCM2_MOUSE 1 MAESSESLSASSPARQRRRISDPLTSSPGRSSRRADALTSSPGRDLPPFEDESEGLLGTEGPMEEEEDGEELIGDGMERDYRPIPELDVYEAEGLALDDEDVEELTASQREAAERTMRQRDREAGRGLGRMRRGLLYDSSEEDEERPARKRRHVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEINMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATIILANHVAKKDNKVAVGELTDEDVKMITGLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKKDEGLTNGGTLEPAMPNTYGVEPLPQEVLKKYIIYAKERVRPKLNQMDQDKVARMYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVMEDDVNMAIRVMMESFIDTQKFSVMRSMRKTFARYLSFRRDNNDLLLFILKQLVAEQVTYQRNRFGAQQDTIEIPEKDLMDKARQINIHNLSAFYDSDLFKFNKFSRDLKRKLILQQF 904
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Pruitt SC, Bailey KJ, Freeland A:
Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer.
Stem Cells. 2007; 25: 3121-32.
PubMed (ID: 17717065), doi:10.1634/stemcells.2007-0483
MeSH Terms: Cell Cycle Proteins/genetics; Gene Expression Regulation, Neoplastic/physiology; Lymphoma/genetics; Lymphoma/pathology; Nuclear Proteins/deficiency; Nuclear Proteins/genetics; Stem Cells/metabolism; Stem Cells/pathology
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot