Gene: RAD51 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | RAD51 | ||||||||||||||||
NCBI Gene ID | : | 5888 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | BRCA1/BRCA2-containing complex, subunit 5 | BRCC5 | DNA repair protein RAD51 homolog 1 | HRAD51 | HsRad51 | HsT16930 | MRMV2 | RAD51 | RAD51 (S. cerevisiae) homolog (E coli RecA homolog) | RAD51 homolog (RecA homolog, E. coli) | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | RAD51 homolog (S. cerevisiae) | RAD51 homolog A | RAD51, S. CEREVISIAE, HOMOLOG OF | RAD51, S. CEREVISIAE, HOMOLOG OF, A | RAD51A | RECA | RECA, E. COLI, HOMOLOG OF | RecA, E. coli, homolog of | RecA-like protein | RECOMBINATION PROTEIN A | recombination protein A Source: GPSDB |
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Gene Homologs | : | AGOS_ACR226W (Eremothecium gossypii) | KLLA0E20241g (Kluyveromyces lactis) | LOC708579 (Macaca mulatta) | MGG_11350 (Magnaporthe oryzae) | NCU02741 (Neurospora crassa) | Os11g0615800 (Oryza sativa) | Os12g0497300 (Oryza sativa) | rad-51 (Caenorhabditis elegans) | RAD51 (Arabidopsis thaliana) | RAD51 (Bos taurus) | RAD51 (Canis lupus familiaris) | rad51 (Danio rerio) | RAD51 (Gallus gallus) | RAD51 (Homo sapiens) | Rad51 (Mus musculus) | RAD51 (Pan troglodytes) | Rad51 (Rattus norvegicus) | RAD51 (Saccharomyces cerevisiae) | rhp51 (Schizosaccharomyces pombe) | spn-A (Drosophila melanogaster) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_004074 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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DNA repair protein RAD51 homolog 1 | Homo sapiens | Q06609 (UniProtKB/Swiss-Prot) | RAD51_HUMAN (UniProtKB/Swiss-Prot) | Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_009747 | Homo sapiens |
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Involved in DNA unwinding and repair [0489], RAD51 has been reported to be an important player in the cellular senescence of yeast [0192]. Disruption of RAD51 in mice results in embryonic lethality [0488]. Its role in mammalian ageing remains unknown. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
RAD51_HUMAN | Q06609 | DNA repair protein RAD51 homolog 1 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 339 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 RAD51_HUMAN 1 MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD 339
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Tsuzuki T, Fujii Y, Sakumi K, Tominaga Y, Nakao K, Sekiguchi M, Matsushiro A, Yoshimura Y, MoritaT :
Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.
Proc Natl Acad Sci USA. 1996; 93: 6236-40.
PubMed (ID: 8692798), PubMed Central (ID: PMC39005)
MeSH Terms: DNA-Binding Proteins/genetics; Genes, Lethal; Mice, Inbred C57BL/embryology - Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E, Odijk H, Oostendorp R, Ahmad A, van Leeuwen W, Theil AF, Vermeulen W, van der Horst GT, Meinecke P, Kleijer WJ, Vijg J, Jaspers NG, Hoeijmakers JH:
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.
Nature. 2006; 444: 1038-43.
PubMed (ID: 17183314), doi:10.1038/nature05456
MeSH Terms: DNA Damage; Progeria/genetics; Progeria/physiopathology; Somatotrophs/metabolism - Park PU, Defossez PA, Guarente L:
Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae.
Mol Cell Biol. 1999; 19: 3848-56.
PubMed (ID: 10207108), PubMed Central (ID: PMC84236)
MeSH Terms: Cell Aging/genetics; DNA Repair/genetics; DNA, Circular/genetics; DNA, Ribosomal/genetics; Saccharomyces cerevisiae/genetics; Silent Information Regulator Proteins, Saccharomyces cerevisiae - Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL, Venkitaraman AR:
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Nature. 2002; 420: 287-93.
PubMed (ID: 12442171), doi:10.1038/nature01230
MeSH Terms: BRCA2 Protein/chemistry; BRCA2 Protein/metabolism; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/metabolism; Recombination, Genetic - Donoho G, Brenneman MA, Cui TX, Donoviel D, Vogel H, Goodwin EH, Chen DJ, Hasty P:
Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice.
Genes Chromosomes Cancer. 2003; 36: 317-31.
PubMed (ID: 12619154), doi:10.1002/gcc.10148
MeSH Terms: BRCA2 Protein/genetics; Chromosome Fragility/genetics; DNA Adducts/genetics; Exons/genetics; Longevity/genetics; Sequence Deletion - Grandin N, Charbonneau M:
The Rad51 pathway of telomerase-independent maintenance of telomeres can amplify TG1-3 sequences in yku and cdc13 mutants of Saccharomyces cerevisiae.
Mol Cell Biol. 2003; 23: 3721-34.
PubMed (ID: 12748277), PubMed Central (ID: PMC155211)
MeSH Terms: DNA-Binding Proteins/metabolism; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae/genetics; Telomerase/metabolism; Telomere-Binding Proteins/genetics; Telomere/metabolism - Linke SP, Sengupta S, Khabie N, Jeffries BA, Buchhop S, Miska S, Henning W, Pedeux R, Wang XW, Hofseth LJ, Yang Q, Garfield SH, Stürzbecher HW, Harris CC:
p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination.
Cancer Res. 2003; 63: 2596-605.
PubMed (ID: 12750285)
MeSH Terms: DNA-Binding Proteins/physiology; Nuclear Proteins/physiology; Recombination, Genetic/physiology; Tumor Suppressor Protein p53/physiology - Yang S, Chintapalli J, Sodagum L, Baskin S, Malhotra A, Reiss K, Meggs LG:
Activated IGF-1R inhibits hyperglycemia-induced DNA damage and promotes DNA repair by homologous recombination.
Am J Physiol Renal Physiol. 2005; 289: F1144-52.
PubMed (ID: 15956778), doi:10.1152/ajprenal.00094.2005
MeSH Terms: DNA Damage; Hyperglycemia/complications; Receptor, IGF Type 1/physiology; Recombination, Genetic - Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadiñanos J, López-Otín C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z:
Genomic instability in laminopathy-based premature aging.
Nat Med. 2005; 11: 780-5.
PubMed (ID: 15980864), doi:10.1038/nm1266
MeSH Terms: Aging, Premature/genetics; DNA Damage/genetics; DNA Repair/physiology; Genomic Instability; Lamin Type A/genetics; Membrane Proteins/genetics; Metalloendopeptidases/genetics - Petkovic M, Dietschy T, Freire R, Jiao R, Stagljar I:
The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability.
J Cell Sci. 2005; 118: 4261-9.
PubMed (ID: 16141230), doi:10.1242/jcs.02556
MeSH Terms: Adenosine Triphosphatases/metabolism; DNA Helicases/metabolism; Genomic Instability/physiology; Rothmund-Thomson Syndrome/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot