Gene: Bub1b - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Bub1b |
NCBI Gene ID |
: |
12236 |
Species |
: |
Mus musculus |
Gene Synonyms |
: |
Bub1b | BUBR1 | budding uninhibited by benzimidazoles 1 beta | budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) | MAD3/BUB1-related protein kinase | Mad3l | mitotic checkpoint kinase MAD3L | mitotic checkpoint serine/threonine-protein kinase BUB1 beta | RP23-204G5.1
Source: GPSDB |
Gene Homologs |
: |
AT2G33560.1 (Arabidopsis thaliana) | BUB1B (Bos taurus) | BUB1B (Canis lupus familiaris) | BUB1B (Gallus gallus) | BUB1B (Homo sapiens) | BUB1B (Macaca mulatta) | Bub1b (Mus musculus) | BUB1B (Pan troglodytes) | Bub1b (Rattus norvegicus) | bub1bb (Danio rerio) | Os02g0193600 (Oryza sativa) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
decreased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_004105 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta |
Mus musculus |
Q9Z1S0 (UniProtKB/Swiss-Prot) |
BUB1B_MOUSE (UniProtKB/Swiss-Prot) |
Essential component of the mitotic checkpoint. Required for normal mitosis progression and tumor suppression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. Essential for tumor suppression. May play a role in regulating aging and fertility. |
View |
Putative uncharacterized protein |
Mus musculus |
Q3UZD6 (UniProtKB/TrEMBL) |
Q3UZD6_MOUSE (UniProtKB/TrEMBL) |
|
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005710 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Bub1b |
12236 |
|
|
Knockout mutant mice exhibit symptoms of accelerated ageing such as short lifespan, lordokyphosis, and fat loss. |
15208629 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_000728 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Bub1b |
Mus musculus |
12236 |
loss of function |
- |
unknown |
unknown |
|
|
|
decreased |
-60.00% |
6 |
15 |
|
mean |
|
|
|
Knockout mutant mice exhibit a minimum of 60% shorter lifespan. Also exhibit lordokyphosis and fat loss. |
Baker et al. |
2004 |
15208629 |
doi:10.1038/ng1382 |
Lifespan Observations Database (ID: 1992) |
2 |
OB_005711 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Bub1b |
Mus musculus |
12236 |
Knockout |
- |
wildtype |
yes |
|
|
|
decreased |
|
|
|
|
unknown |
|
|
|
Knockout mutant mice exhibit symptoms of accelerated ageing such as short lifespan, lordokyphosis, and fat loss. |
Baker et al. |
2004 |
15208629 |
doi:10.1038/ng1382 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008837 |
|
2 |
The HomoloGene homology group 933 contains 2 genes with experimental evidence for ageing relevance (BUB1B - Homo sapiens | Bub1b - Mus musculus) and 9 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 933 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, Kumar R, Jenkins RB, de Groen PC, Roche P, van Deursen JM:
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.
Nat Genet. 2004; 36: 744-9.
PubMed (ID: 15208629), doi:10.1038/ng1382
MeSH Terms: Aging/genetics; Infertility, Female/genetics; Infertility, Male/genetics; Protein Kinases/physiology
Sources
Ageing-related Data Sources
Additional Data Sources