Gene: bchs - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
bchs |
NCBI Gene ID |
: |
33819 |
Species |
: |
Drosophila melanogaster |
Gene Synonyms |
: |
alfy | bchd | Bchs | bchs | bchs-PA | Beach1 | Beached | beached | Beached 1 | beached 1 | Beached1 | Blue Cheese | Blue cheese | blue cheese | CG14001 | CG14001-PA | CG9011 | DBEACH1 | dbeach1 | Dmel_CG14001 | DmelCG14001 | EP2299
Source: GPSDB |
Gene Homologs |
: |
bchs (Drosophila melanogaster) | C26H9A.2 (Caenorhabditis elegans) | si:ch211-259k10.1 (Danio rerio) | WDFY3 (Bos taurus) | WDFY3 (Canis lupus familiaris) | WDFY3 (Gallus gallus) | WDFY3 (Homo sapiens) | WDFY3 (Macaca mulatta) | Wdfy3 (Mus musculus) | WDFY3 (Pan troglodytes) | Wdfy3 (Rattus norvegicus) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_004124 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005509 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
bchs |
33819 |
|
|
Mean lifespan is decreased 40-45% in bchs mutant adults. No pronounced developmental defects were observed and young adults have normal behaviors, indicating that the bchs gene is essential for normal adult survival and longevity. |
12598614 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_002210 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
bchs |
Drosophila melanogaster |
33819 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
42.00% |
|
|
|
|
|
|
|
Mean lifespan is decreased 40-45% in bchs mutant adults. Other phenotypes: No pronounced developmental defects were observed and young adults have normal behaviors, indicating that the bchs gene is essential for normal adult survival and longevity. |
Finley et al. |
2003 |
12598614 |
|
Lifespan Observations Database (ID: 348) |
2 |
OB_005511 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
bchs |
Drosophila melanogaster |
33819 |
Mutations |
- |
wildtype |
yes |
|
|
|
decreased |
-13.00% |
|
|
|
maximum |
|
|
|
Mutants showed a 13% reduction in maximum lifespan. |
Simonsen et al. |
2007 |
17435236 |
doi:10.1534/genetics.106.065011 |
GenAge |
3 |
OB_005512 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
bchs |
Drosophila melanogaster |
33819 |
Mutation |
- |
wildtype |
yes |
|
|
|
decreased |
-40.00% |
|
|
|
maximum |
|
|
|
Mutants showed a 40% reduction in maximum lifespan. |
Simonsen et al. |
2007 |
17617737 |
|
GenAge |
4 |
OB_005510 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
bchs |
Drosophila melanogaster |
33819 |
Mutation |
- |
wildtype |
yes |
|
|
|
decreased |
-45.00% |
|
|
|
Average |
|
|
|
Mean lifespan is decreased 40-45% in bchs mutant adults. No pronounced developmental defects were observed and young adults have normal behaviors, indicating that the bchs gene is essential for normal adult survival and longevity. |
Finley et al. |
2003 |
12598614 |
|
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008887 |
|
1 |
The HomoloGene homology group 22855 contains 1 gene with experimental evidence for ageing relevance (bchs - Drosophila melanogaster) and 10 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 22855 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Finley KD, Edeen PT, Cumming RC, Mardahl-Dumesnil MD, Taylor BJ, Rodriguez MH, Hwang CE, Benedetti M, McKeown M:
blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration.
J Neurosci. 2003; 23: 1254-64.
PubMed (ID: 12598614), PubMed Central (ID: PMC1975817)
MeSH Terms: Drosophila Proteins/genetics; Drosophila Proteins/physiology; Membrane Proteins; Nerve Degeneration/etiology; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology
- Simonsen A, Cumming RC, Lindmo K, Galaviz V, Cheng S, Rusten TE, Finley KD:
Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.
Genetics. 2007; 176: 1283-97.
PubMed (ID: 17435236), PubMed Central (ID: PMC1894590), doi:10.1534/genetics.106.065011
MeSH Terms: Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila/genetics; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Ubiquitin/metabolism
- Simonsen A, Cumming RC, Finley KD:
Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila.
Autophagy. 2007; 3: 499-501.
PubMed (ID: 17617737)
MeSH Terms: Aging/metabolism; Drosophila/metabolism; Lysosomes/metabolism
Sources
Ageing-related Data Sources
Additional Data Sources