Gene: mys - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
mys |
NCBI Gene ID |
: |
44885 |
Species |
: |
Drosophila melanogaster |
Gene Synonyms |
: |
b[[PS]] | beta integrin | beta PS integrin | beta-Int | beta-int | beta-Integrin | beta-integrin | beta-PS | beta-PS Integrin | beta-PS integrin | beta-PS-Integrin | beta-PS1 integrin | beta1 | beta1 integrin | beta[[mys]] | beta[[mys]]-integrin | beta[[P]]S | beta[[PS]] | beta[[PS]] integrin | beta[[PS]]-integrin | betaInt | betaIntegrin | betamys | BetaPS | betaPS | betaPS Int | BetaPS integrin | betaPS integrin | BetaPS-Int | betaPS-integrin | betaps-integrin | betaPS.*integrin | betaPS1 | bPS | CG1560 | CG1560-PA | CT40473 | Dmel_CG1560 | DmelCG1560 | EM28 | Integrin | integrin | integrin beta[[PS]] | integrin beta[[PS]] subunit | Integrin betaPS | integrin betaPS | integrin PSbeta | Integrin-betaPS | integrin-betaPS | l(1)7Db | l(1)7Dn | l(1)93p | l(1)968 | l(1)DA551 | l(1)EM28 | l(1)G0233 | l(1)G0281 | l(1)mys | lethal myospheroid | lethal(1)93 pupal | lethal(1)myospheroid | MAb6G11 | myo-spheroid | Myospheriod | myospheriod | Myospheroid | myospheroid | Mys | mys | mys-PA | nj42 | non-jumper-42 | olfactory C | olfactory-C | olfC | PS | PS integrin beta subunit | PS-beta-integrin | PS[[beta]] | PSbeta | PSbeta-integrin
Source: GPSDB |
Gene Homologs |
: |
INTB (Anopheles gambiae) | ITGB1 (Bos taurus) | ITGB1 (Canis lupus familiaris) | ITGB1 (Gallus gallus) | ITGB1 (Homo sapiens) | ITGB1 (Macaca mulatta) | Itgb1 (Mus musculus) | ITGB1 (Pan troglodytes) | Itgb1 (Rattus norvegicus) | itgb1a (Danio rerio) | itgb1b (Danio rerio) | mys (Drosophila melanogaster) | pat-3 (Caenorhabditis elegans) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_004137 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
Integrin beta-PS |
Drosophila melanogaster |
P11584 (UniProtKB/Swiss-Prot) |
ITBX_DROME (UniProtKB/Swiss-Prot) |
Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig (Tiggrin). Also binds to wb (wing blister) and Ten-m (Tenascin major). Required for many embryonic (dorsal closure and somatic muscle attachments) and post-embryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development). Involved in the function and/or development of the olfactory system. |
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005600 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
mys |
44885 |
|
|
Mutants exhibit ameliorated age-related declines in locomotor activity and an increase in mean lifespan of 20%. |
14570233 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_003014 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mys |
Drosophila melanogaster |
44885 |
loss of function |
xG |
unknown |
unknown |
|
|
|
increased |
20.69% |
70 |
58 |
days |
mean |
25 |
℃ |
female |
Heterozygous mutants exhibit an increase in mean lifespan of 20%. Other phenotypes: Mutants also exhibit ameliorated age-related declines in locomotor activity. |
Goddeeris et al. |
2003 |
14570233 |
|
Lifespan Observations Database (ID: 4347) |
2 |
OB_003015 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mys |
Drosophila melanogaster |
44885 |
loss of function |
ts2 |
unknown |
unknown |
|
|
|
increased |
20.00% |
90 |
75 |
days |
mean |
25 |
℃ |
female |
Homozygous mutants exhibit an increase in mean lifespan of 20%. Other phenotypes: Mutants also exhibit ameliorated age-related declines in locomotor activity. |
Goddeeris et al. |
2003 |
14570233 |
|
Lifespan Observations Database (ID: 4348) |
3 |
OB_005601 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mys |
Drosophila melanogaster |
44885 |
Mutation |
- |
wildtype |
yes |
|
|
|
increased |
20.00% |
|
|
|
unknown |
|
|
female |
Mutants exhibit ameliorated age-related declines in locomotor activity and an increase in mean lifespan of 20%. |
Goddeeris et al. |
2003 |
14570233 |
|
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_009353 |
|
1 |
The HomoloGene homology group 22999 contains 1 gene with experimental evidence for ageing relevance (mys - Drosophila melanogaster) and 12 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 22999 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Goddeeris MM, Cook-Wiens E, Horton WJ, Wolf H, Stoltzfus JR, Borrusch M, Grotewiel MS:
Delayed behavioural aging and altered mortality in Drosophila beta integrin mutants.
Aging Cell. 2003; 2: 257-64.
PubMed (ID: 14570233)
MeSH Terms: Cell Aging/genetics; Drosophila Proteins/physiology; Drosophila/cytology; Integrins/physiology
Sources
Ageing-related Data Sources
Additional Data Sources