Gene: ERG5 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Gene Symbol | : | ERG5 | ||||||||||||||||
NCBI Gene ID | : | 855029 | ||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||
Gene Synonyms | : | C-22 sterol desaturase | CYP61 | ERG5 | Erg5p | YM9711.02C | YMR015C Source: GPSDB |
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Gene Homologs | : | AT2G28850.1 (Arabidopsis thaliana) | CYP710A1 (Arabidopsis thaliana) | CYP710A2 (Arabidopsis thaliana) | CYP710A4 (Arabidopsis thaliana) | ERG5 (Saccharomyces cerevisiae) | erg5 (Schizosaccharomyces pombe) | KLLA0D11242g (Kluyveromyces lactis) | MGG_06047 (Magnaporthe oryzae) | NCU05278 (Neurospora crassa) | Os01g0210900 (Oryza sativa) | Os01g0211000 (Oryza sativa) | Os01g0211200 (Oryza sativa) | Os01g0211600 (Oryza sativa) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_004167 | ||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||||
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1 | OB_007961 | Saccharomyces cerevisiae |
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Deletion of ERG5 decreases replicative lifespan by 35% in the a strain [ 18340043], but increases mean chronological lifespan by 26 - 116% (26, 40, 43, 62, 116) in diploid cells [ 21447998]. Deletion of ERG5 cancels out the replicative lifespan extension of 0.5% glucose restriction [ 18690010]. | 18690010 | GenDR |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_007497 | Saccharomyces cerevisiae |
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decreased | -35.00% | unknown | Replicative lifespan decreased by 35% in the a strain | Smith et al. | 2008 | 18340043 | doi:10.1101/gr.074724.107 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
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1 | OB_008329 | 1 | The HomoloGene homology group 20212 contains 1 gene with experimental evidence for ageing relevance (ERG5 - Saccharomyces cerevisiae) and 12 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 20212 |
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Smith ED, Tsuchiya M, Fox LA, Dang N, Hu D, Kerr EO, Johnston ED, Tchao BN, Pak DN, Welton KL, Promislow DE, Thomas JH, Kaeberlein M, Kennedy BK:
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.
Genome Res. 2008; 18: 564-70.
PubMed (ID: 18340043), PubMed Central (ID: PMC2279244), doi:10.1101/gr.074724.107
MeSH Terms: Caenorhabditis elegans/genetics; Longevity/genetics; Saccharomyces cerevisiae/genetics - Tang F, Watkins JW, Bermudez M, Gray R, Gaban A, Portie K, Grace S, Kleve M, Craciun G:
A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery.
Autophagy. 2008; 4: 874-86.
PubMed (ID: 18690010)
MeSH Terms: Autophagy; Longevity; Membrane Fusion; Saccharomyces cerevisiae Proteins/physiology; Saccharomyces cerevisiae/physiology; Vacuoles/physiology
Sources
Ageing-related Data Sources
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed