Gene: Cebpa - Mus musculus(see also ageing factor AF_008748 *)
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Cebpa | ||||||||||||||||
NCBI Gene ID | : | 12606 * | ||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||
Gene Synonyms | : | C/EBP alpha | C/ebpalpha | CBF-A | CCAAT/enhancer binding protein (C/EBP), alpha | CCAAT/enhancer-binding protein alpha | Cebp | Cebpa Source: GPSDB |
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Gene Homologs | : | CEBPA (Bos taurus) | cebpa (Danio rerio) | CEBPA (Gallus gallus) | CEBPA (Homo sapiens) | Cebpa (Mus musculus) | Cebpa (Rattus norvegicus) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_004186 | ||||||||||||||||
Download | : | XML |
*
AgeFactDB contains further genes associated with gene symbol Cebpa and the species Mus musculus: AF_008748
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
CCAAT/enhancer-binding protein alpha | Mus musculus | P53566 (UniProtKB/Swiss-Prot) | CEBPA_MOUSE (UniProtKB/Swiss-Prot) | C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_005642 | Mus musculus |
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Replacing the CEBPA gene by CEBPB increased lifespan by about 20%. | 15289464 | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_008623 |
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2 | The HomoloGene homology group 3211 contains 2 genes with experimental evidence for ageing relevance (CEBPA - Homo sapiens | Cebpa - Mus musculus) and 4 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 3211 |
Sequences
CEBPA_MOUSE | P53566 | CCAAT/enhancer-binding protein alpha (Mus musculus) from UniProtKB/Swiss-Prot Length: 359 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 CEBPA_MOUSE 1 MESADFYEVEPRPPMSSHLQSPPHAPSNAAFGFPRGAGPAPPPAPPAAPEPLGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAAGPAGGGGDFDYPGAPAGPGGAVMSAGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFPYQPPPPPPPPHPHASPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHAAPALGAAGLPGPGSALKGLAGAHPDLRTGGGGGGSGAGAGKAKKSVDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA 359
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Chiu CH, Lin WD, Huang SY, Lee YH:
Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells.
Genes Dev. 2004; 18: 1970-5.
PubMed (ID: 15289464), PubMed Central (ID: PMC514177), doi:10.1101/gad.1213104
MeSH Terms: CCAAT-Enhancer-Binding Protein-alpha/genetics; CCAAT-Enhancer-Binding Protein-beta/genetics; GTP-Binding Proteins/metabolism; Mitochondria/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot