1 |
OB_003225 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sod-3 |
Caenorhabditis elegans |
181748 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
200 |
mM |
|
|
increased |
140.00% |
600 |
250 |
|
mean |
25 |
℃ |
|
In an acute survival test using 200 mM paraquat solution, sod-1 worms were hypersensitive to paraquat, whereas, surprisingly, sod-3 or sod-4 worms actually had a reduced sensitivity to paraquat. Mutational inactivation of other isoforms of sod had no effect on sensitivity to paraquat in this acute assay. |
Yen et al. |
2009 |
19059428 |
doi:10.1016/j.mad.2008.11.003 |
Lifespan Observations Database (ID: 4634) |
2 |
OB_008094 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
sod-3 |
Caenorhabditis elegans |
181748 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
increased |
83.00% |
55 |
30 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
3 |
OB_008123 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
sod-3 |
Caenorhabditis elegans |
181748 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
increased |
77.00% |
37.1 |
21 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
4 |
OB_003204 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sod-3 |
Caenorhabditis elegans |
181748 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
17.48% |
16.8 |
14.3 |
days |
mean |
25 |
℃ |
|
Under control conditions (25 8C, ad lib fed) mutational inactivation of each sod isoform produced no significant effects on average lifespan. |
Yen et al. |
2009 |
19059428 |
doi:10.1016/j.mad.2008.11.003 |
Lifespan Observations Database (ID: 4615) |
5 |
OB_003219 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sod-3 |
Caenorhabditis elegans |
181748 |
deletion / null |
- |
unknown |
unknown |
|
|
|
none |
3.51% |
35.4 |
34.2 |
days |
mean |
16 |
℃ |
|
CHIL significantly increased average lifespan in sod mutants relative to standard temperature lifespan of mutant. There was no significant difference between mutant and N2 controls at 16 degrees. |
Yen et al. |
2009 |
19059428 |
doi:10.1016/j.mad.2008.11.003 |
Lifespan Observations Database (ID: 4629) |
6 |
OB_008091 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sod-3 |
Caenorhabditis elegans |
181748 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
none |
0.00% |
30 |
30 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
7 |
OB_008120 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sod-3 |
Caenorhabditis elegans |
181748 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
none |
-2.00% |
20.6 |
21 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
8 |
OB_003210 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sod-3 |
Caenorhabditis elegans |
181748 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Adult worms were transferred to liquid axenic media (3% soy protein, 3% yeast extract, .05% hemogloblin (Houthoofd et al., 2002) and 5 mg/L of cholesterol) that was supplemented with tetracycline (12.5 mg/L) and ampicillin (100 mg/L) to prevent bacterial growth. The worms were transferred to fresh media approximately every 2 weeks. |
|
decreased |
-6.56% |
22.8 |
24.4 |
days |
mean |
25 |
℃ |
|
Inactivation of sod isoforms had no significant effect on the increased lifespan from dietary restriction. |
Yen et al. |
2009 |
19059428 |
doi:10.1016/j.mad.2008.11.003 |
Lifespan Observations Database (ID: 4620) |