Gene: hsp-6 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
hsp-6 |
NCBI Gene ID |
: |
178873 |
Species |
: |
Caenorhabditis elegans |
Gene Synonyms |
: |
C37H5.8 | CE08631 | CELE_C37H5.8 | hsp-6 | hsp70f | mot-2 | Protein HSP-6 | WP:CE08631
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP010876 (Anopheles gambiae) | AGOS_AFR352C (Eremothecium gossypii) | Hsc70-5 (Drosophila melanogaster) | hsp-6 (Caenorhabditis elegans) | HSP70-10 (Arabidopsis thaliana) | HSPA9 (Bos taurus) | HSPA9 (Canis lupus familiaris) | hspa9 (Danio rerio) | HSPA9 (Gallus gallus) | HSPA9 (Homo sapiens) | HSPA9 (Macaca mulatta) | Hspa9 (Mus musculus) | HSPA9 (Pan troglodytes) | Hspa9 (Rattus norvegicus) | KLLA0E22309g (Kluyveromyces lactis) | MGG_04191 (Magnaporthe oryzae) | NCU08693 (Neurospora crassa) | Os02g0774300 (Oryza sativa) | Os03g0113700 (Oryza sativa) | SSC1 (Saccharomyces cerevisiae) | ssc1 (Schizosaccharomyces pombe) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_004458 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005380 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
hsp-6 |
178873 |
|
|
Knockdown of HSP-6 by RNAi in young adult nematodes caused a reduction in the levels of ATP-2, HSP-60 and CLK-1, leading to abnormal mitochondrial morphology and lower ATP level. As a result, RNAi-treated worms had lower motility, defects in oogenesis, earlier accumulation of autofluorescent material and a shorter lifespan (15% reduction). |
17189267 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_005379 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hsp-6 |
Caenorhabditis elegans |
178873 |
Overexpression |
- |
wildtype |
yes |
|
|
|
increased |
45.00% |
|
|
|
maximum |
|
|
|
Overexpression in transgenic worms extended lifespan by 43% for mean and 45% for maximum lifespan. |
Yokoyama et al. |
2002 |
11959102 |
|
GenAge |
2 |
OB_003820 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hsp-6 |
Caenorhabditis elegans |
178873 |
over-expression |
- |
unknown |
unknown |
|
|
|
increased |
43.00% |
|
|
|
|
|
|
|
Overexpression in transgenic worms extended lifespan by 43% for mean and 45% for maximum lifespan. |
Yokoyama et al. |
2002 |
11959102 |
|
Lifespan Observations Database (ID: 543) |
3 |
OB_005381 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hsp-6 |
Caenorhabditis elegans |
178873 |
RNA interference |
- |
wildtype |
yes |
|
|
|
decreased |
-15.00% |
|
|
|
unknown |
|
|
|
Knockdown of HSP-6 by RNAi in young adult nematodes caused a reduction in the levels of ATP-2, HSP-60 and CLK-1, leading to abnormal mitochondrial morphology and lower ATP level. As a result, RNAi-treated worms had lower motility, defects in oogenesis, earlier accumulation of autofluorescent material and a shorter lifespan (15% reduction). |
Kimura et al. |
2007 |
17189267 |
doi:10.1074/jbc.M609025200 |
GenAge |
4 |
OB_000136 |
Caenorhabditis elegans |
Bristol N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hsp-6 |
Caenorhabditis elegans |
178873 |
over-expression |
- |
unknown |
unknown |
|
|
|
increased |
|
|
|
|
|
|
|
|
Overexpression of hsp70F from a muscle-specific promoter increased life-span (mean increase: 43%, maximum increase: 45%) relative to animals expressing GFP from the same promoter. Other phenotypes: C. elegans hsp70F is the homolog of mammalian mortalin (mot-2/mthsp70/Grp75) [ 2766926], which has been shown to be capable of increasing the proliferative potential of normal fibroblasts when overexpressed [ 10838077]. The hsp70F transgene was integrated into the genome, not an extrachromosomal array. It was confirmed immunohistochemically to be expressed predominantly in muscle [ 11959102]. |
Yokoyama et al. |
2002 |
11959102 |
|
Lifespan Observations Database (ID: 114) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008945 |
|
2 |
The HomoloGene homology group 39452 contains 2 genes with experimental evidence for ageing relevance (HSPA9 - Homo sapiens | hsp-6 - Caenorhabditis elegans) and 19 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 39452 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Yokoyama K, Fukumoto K, Murakami T, Harada S, Hosono R, Wadhwa R, Mitsui Y, Ohkuma S:
Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75.
FEBS Lett. 2002; 516: 53-7.
PubMed (ID: 11959102)
MeSH Terms: Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans/genetics; Genes, Helminth; HSP70 Heat-Shock Proteins/genetics; Longevity/genetics
- Kimura K, Tanaka N, Nakamura N, Takano S, Ohkuma S:
Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans.
J Biol Chem. 2007; 282: 5910-8.
PubMed (ID: 17189267), doi:10.1074/jbc.M609025200
MeSH Terms: Caenorhabditis elegans/genetics; HSP70 Heat-Shock Proteins/deficiency; Longevity/genetics; Mitochondrial Proteins/deficiency; Oogenesis/genetics
Sources
Ageing-related Data Sources
Additional Data Sources