Gene: ire-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
ire-1 |
NCBI Gene ID |
: |
174305 |
Species |
: |
Caenorhabditis elegans |
Gene Synonyms |
: |
C41C4.4 | CE35836 | CELE_C41C4.4 | ire-1 | Protein IRE-1 | WP:CE35836
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP004176 (Anopheles gambiae) | ERN1 (Bos taurus) | ERN1 (Canis lupus familiaris) | ERN1 (Gallus gallus) | ERN1 (Homo sapiens) | ERN1 (Macaca mulatta) | Ern1 (Mus musculus) | ERN1 (Pan troglodytes) | Ern1 (Rattus norvegicus) | ern2 (Danio rerio) | ire-1 (Caenorhabditis elegans) | Ire1 (Drosophila melanogaster) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_004474 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
Serine/threonine-protein kinase/endoribonuclease ire-1 |
Caenorhabditis elegans |
Q09499 (UniProtKB/Swiss-Prot) |
IRE1_CAEEL (UniProtKB/Swiss-Prot) |
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes. Unfolded protein response (UPR) transcripional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis. Ire-1 and pek-1 are redundant genes that control a pathway essential for larval development and survival. |
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_008000 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
ire-1 |
174305 |
|
Other Ageing Factor Name |
Dietary restriction |
|
ire-1 mutation reduces slightly the lifespan under AL, but reduces significantly the lifespan extension by DR. ire-1 mutant has a significantly reduced slope in mean lifespan versus food concentrations relative to wild-type. ire-1 mutation fully suppresses lifespan extension by hif-1 mutation under AL and DR conditions [ 19461873]. |
19461873 |
GenDR |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_006531 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ire-1 |
Caenorhabditis elegans |
174305 |
Mutation |
- |
wildtype |
yes |
|
|
|
decreased |
-20.00% |
|
|
|
Average |
|
|
|
Average lifespan decreased by 20% compared to wild type. |
Henis-Korenblit et al. |
2010 |
20460307 |
doi:10.1073/pnas.1002575107 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_009011 |
|
1 |
The HomoloGene homology group 55580 contains 1 gene with experimental evidence for ageing relevance (ire-1 - Caenorhabditis elegans) and 11 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 55580 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Chen D, Thomas EL, Kapahi P:
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans.
PLoS Genet. 2009; 5: e1000486.
PubMed (ID: 19461873), PubMed Central (ID: PMC2676694), doi:10.1371/journal.pgen.1000486
MeSH Terms: Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/physiology; Caloric Restriction; Hypoxia-Inducible Factor 1/physiology; Longevity/physiology
- Henis-Korenblit S, Zhang P, Hansen M, McCormick M, Lee SJ, Cary M, Kenyon C:
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity.
Proc Natl Acad Sci USA. 2010; 107: 9730-5.
PubMed (ID: 20460307), PubMed Central (ID: PMC2906894), doi:10.1073/pnas.1002575107
MeSH Terms: Caenorhabditis elegans/metabolism; Endoplasmic Reticulum/metabolism; Longevity; Mutation; Signal Transduction; Stress, Physiological
Sources
Ageing-related Data Sources
Additional Data Sources