Gene: bar-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | bar-1 | ||||||||||||||||||||
NCBI Gene ID | : | 180982 | ||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||
Gene Synonyms | : | bar-1 | C54D1.6 | CE08973 | CELE_C54D1.6 | Protein BAR-1 | pvl-1 | spy-1 | WP:CE08973 Source: GPSDB |
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Gene Homologs | : | |||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_004553 | ||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Beta-catenin/armadillo-related protein 1 | Caenorhabditis elegans | Q18825 (UniProtKB/Swiss-Prot) | BAR1_CAEEL (UniProtKB/Swiss-Prot) | Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectodermal cell P12 specification, movement, body length, male tail development and dauer induction. Functionally redundant to wrm-1 and hmp-2. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_005466 | Caenorhabditis elegans |
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May play a role in regulating daf-16 during dauer formation, particularly in conditions of oxidative stress. Deletion of bar-1 reduces mean (45%) and maximal (35%) lifespan. | 15905404 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_002188 | Caenorhabditis elegans |
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increased | 45.00% | Deletion of bar-1 reduces mean (45%) and maximal (35%) lifespan. Other phenotypes: May play a role in regulating daf-16 during dauer formation, particularly in conditions of oxidative stress. | Essers et al. | 2005 | 15905404 | doi:10.1126/science.1109083 | Lifespan Observations Database (ID: 346) | ||||||||||||||||||||||||
2 | OB_005467 | Caenorhabditis elegans |
|
decreased | -35.00% | maximum | May play a role in regulating daf-16 during dauer formation, particularly in conditions of oxidative stress. Deletion of bar-1 reduces mean (45%) and maximal (35%) lifespan. | Essers et al. | 2005 | 15905404 | doi:10.1126/science.1109083 | GenAge |
Homology Analysis
no homology analysis observation available
Sequences
BAR1_CAEEL | Q18825 | Beta-catenin/armadillo-related protein 1 (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 811 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 BAR1_CAEEL 1 MDLDPNLVINHDDTNLSEASFTMEQHTSSYSDIHMGSTPCTGHRKVDMWRNHNFDSGFQTMNHSEAPSIISSLHPSSHLSGMSSMADYEPIPTLSDQQKQKFDGITQNQADGQYNTVRAIPELTMLMKDQDNEVVHKAVILMQNIAKMECDPMRRQNEARIVDPRVIFTLRDLLRDKVEFPNIIRCTLGTFFHICNRQEGIDLVTRAIAEQPDIIPNLIRHIGTYPSSIYKYAILTMHSILSDKQRGGQSVIIARQQDAITHVTPWLEAEKSEKLLPVIVDLIRVLCEKNTEQKIKFVKMGGPQKLLMLLQHRVYENLLWRTTQLLKTFSNFDAPNLVAFGGRQILANLLSHGSPRLVQSTLETLRNISDVPSKIKEDLLLKSLLELVNSRNTTIRLYSAQIMSNLVANNRHNKEFMCGNNGVVILVRALTIATKEMGDLRDKEAQQMEDYIESLICTLRHLCVGHPMSDKVQAFVFRDPALFLHKLLTMRPVLLKHTLSLLLKVVSQHALLAPFRSCRIGDKGFVEQLIHILRVACTQLNVQESIEGVRVKDIIHLCIQILRWITRDQDILNEVVFFLQTPENSRMGDGHTLPIFVLQKANVEENTKSSALALIYNLMHHEQMANVLDRDDVLVKMLQNVQMQSQTHPELASLANNILKMMYEKREKTRNTLPRYNSYLESQFGHMSMTTPRSEALNSSGEVCEGAGEQWSTPLTDDTMMDSYCNSSGRDSSKPYNSPMYHSPPAMYPEYSIGPPETYLDPHATASCYPRPTPPQYNSYDRSPPVYNDLPSNPGPSSHSSDYYPSRNSRF 811
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Essers MA, de Vries-Smits LM, Barker N, Polderman PE, Burgering BM, Korswagen HC:
Functional interaction between beta-catenin and FOXO in oxidative stress signaling.
Science. 2005; 308: 1181-4.
PubMed (ID: 15905404), doi:10.1126/science.1109083
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/metabolism; Cytoskeletal Proteins/metabolism; Oxidative Stress; Signal Transduction; Trans-Activators/metabolism; Transcription Factors/metabolism
Sources
Ageing-related Data Sources
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot