Gene: SNF4 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | SNF4 | ||||||||||||||||||||||||||||
NCBI Gene ID | : | 852763 | ||||||||||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||||||||||
Gene Synonyms | : | CAT3 | SCI1 | SNF4 | Snf4p | YGL115W Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP001446 (Anopheles gambiae) | AGOS_AFL015C (Eremothecium gossypii) | KLLA0F10769g (Kluyveromyces lactis) | MGG_04005 (Magnaporthe oryzae) | NCU01471 (Neurospora crassa) | Os04g0401300 (Oryza sativa) | PRKAG2 (Canis lupus familiaris) | PRKAG2 (Gallus gallus) | PRKAG2 (Homo sapiens) | Prkag2 (Mus musculus) | PRKAG2 (Pan troglodytes) | Prkag2 (Rattus norvegicus) | SNF4 (Saccharomyces cerevisiae) | SNF4Agamma (Drosophila melanogaster) | SPAC1F12.01c (Schizosaccharomyces pombe) | zgc:153329 (Danio rerio) | ||||||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_004657 | ||||||||||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | |||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | |||||||||||||||||||||
1 | OB_005958 | Saccharomyces cerevisiae |
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increased | 20.00% | unknown | Deleting SNF4 extends lifespan by 10-20%. | Ashrafi et al. | 2000 | 10921902 | GenAge | |||||||||||||||||||||||||||||||
2 | OB_000614 | Saccharomyces cerevisiae | YB332 |
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increased | 13.79% | 33 | 29 | divisions | median | 30 | ℃ | mata | Deletion of SIP2 shortens life span by about 50%. This decreased in life span is suppressed by deletion of SNF4 | Ashrafi et al. | 2000 | 10921902 | Lifespan Observations Database (ID: 1881) | ||||||||||||||||||||||||
3 | OB_004144 | Saccharomyces cerevisiae | BY4742 |
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decreased | -19.00% | 26.9 | mean | 30 | ℃ | The snf4 deletion from the MATalpha haploid yeast orf deletion collection had a shortened replicative life span relative to wild type BY4742 cells. | Kaeberlein et al. | 2005 | 15722108 | doi:10.1016/j.mad.2004.10.007 | Lifespan Observations Database (ID: 837) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
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1 | OB_008570 | 2 | The HomoloGene homology group 90952 contains 2 genes with experimental evidence for ageing relevance (SNF4 - Saccharomyces cerevisiae | SNF4Agamma - Drosophila melanogaster) and 14 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 90952 |
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Ashrafi K, Lin SS, Manchester JK, Gordon JI:
Sip2p and its partner snf1p kinase affect aging in S. cerevisiae.
Genes Dev. 2000; 14: 1872-85.
PubMed (ID: 10921902), PubMed Central (ID: PMC316829)
MeSH Terms: DNA-Binding Proteins/metabolism; Fungal Proteins/metabolism; Protein-Serine-Threonine Kinases/metabolism; Repressor Proteins/metabolism; Saccharomyces cerevisiae Proteins; Saccharomyces cerevisiae/physiology; Trans-Activators - Kaeberlein M, Kirkland KT, Fields S, Kennedy BK:
Genes determining yeast replicative life span in a long-lived genetic background.
Mech Ageing Dev. 2005; 126: 491-504.
PubMed (ID: 15722108), doi:10.1016/j.mad.2004.10.007
MeSH Terms: Cell Aging/genetics; Gene Expression Regulation, Fungal/genetics; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed