Gene: CBX7 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | CBX7 | ||||||||||||||||
NCBI Gene ID | : | 23492 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | CBX7 | CHROMOBOX HOMOLOG 7 | chromobox homolog 7 | chromobox protein homolog 7 | RP4-742C19.7 Source: GPSDB |
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Gene Homologs | : | |||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_004678 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Chromobox protein homolog 7 | Homo sapiens | O95931 (UniProtKB/Swiss-Prot) | CBX7_HUMAN (UniProtKB/Swiss-Prot) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_000043 | Homo sapiens | SGC-7901 |
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decreased | divisions | median | diploid | Knockdown of CBX7 expression in gastric cancer cells led to increased cellular senescence, decreased cellular proliferation and migration ability, accompanied by upregulation of p16(INK4a). CBX7 may act as an oncogene in gastric cancer, and regulate tumorigenesis, cell migration and cancer metastasis partially via p16(INK4a) regulatory pathway. Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating expression of the INK4a/ARF tumor suppressor locus. | Zhang et al. | 2010 | 20723236 | doi:10.1186/1756-9966-29-114 | Lifespan Observations Database (ID: 1039) |
Homology Analysis
no homology analysis observation available
Sequences
CBX7_HUMAN | O95931 | Chromobox protein homolog 7 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 251 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 CBX7_HUMAN 1 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF 251
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Zhang XW, Zhang L, Qin W, Yao XH, Zheng LZ, Liu X, Li J, Guo WJ:
Oncogenic role of the chromobox protein CBX7 in gastric cancer.
J Exp Clin Cancer Res. 2010; 29: 114.
PubMed (ID: 20723236), PubMed Central (ID: PMC2933612), doi:10.1186/1756-9966-29-114
MeSH Terms: Oncogenes; Repressor Proteins/metabolism; Stomach Neoplasms/metabolism
Sources
Ageing-related Data Sources
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot