Gene: EEF1A1 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | EEF1A1 | ||||||||||||||||
NCBI Gene ID | : | 1915 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | CCS-3 | CCS3 | cervical cancer suppressor 3 | CTCL tumor antigen | EE1A1 | EEF-1 | EEF1A | eEF1A-1 | EEF1A1 | EF-1-alpha-1 | EF-Tu | EF1A | EF1a-like protein | elongation factor 1 alpha subunit | ELONGATION FACTOR 1, ALPHA | ELONGATION FACTOR 1, ALPHA-1 | elongation factor 1-alpha 1 | elongation factor Tu | eukaryotic elongation factor 1 A-1 | eukaryotic translation elongation factor 1 alpha 1 | eukaryotic translation elongation factor 1 alpha 1-like 14 | EUKARYOTIC TRANSLATION ELONGATION FACTOR 1, ALPHA-1 | glucocorticoid receptor AF-1 specific elongation factor | GRAF-1EF | HNGC:16303 | LENG7 | leukocyte receptor cluster (LRC) member 7 | leukocyte receptor cluster member 7 | prostate tumor-inducing protein 1 | PTI1 | RP11-505P4.2 | translation elongation factor 1 alpha 1-like 14 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP007406 (Anopheles gambiae) | AGOS_ADL370C (Eremothecium gossypii) | eef-1A.1 (Caenorhabditis elegans) | eef-1A.2 (Caenorhabditis elegans) | eef1a (Danio rerio) | EEF1A1 (Bos taurus) | EEF1A1 (Canis lupus familiaris) | EEF1A1 (Gallus gallus) | EEF1A1 (Homo sapiens) | EEF1A1 (Macaca mulatta) | EEF1A1 (Pan troglodytes) | eef1a1l2 (Danio rerio) | ef1a-b (Schizosaccharomyces pombe) | ef1a-c (Schizosaccharomyces pombe) | Ef1alpha48D (Drosophila melanogaster) | KLLA0B08998g (Kluyveromyces lactis) | LOC100360413 (Rattus norvegicus) | MGG_03641 (Magnaporthe oryzae) | NCU02003 (Neurospora crassa) | TEF1 (Saccharomyces cerevisiae) | tef1a (Schizosaccharomyces pombe) | TEF2 (Saccharomyces cerevisiae) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_004719 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Elongation factor 1-alpha 1 | Homo sapiens | P68104 (UniProtKB/Swiss-Prot) | EF1A1_HUMAN (UniProtKB/Swiss-Prot) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. | View |
Elongation factor 1-alpha | Homo sapiens | Q6IPS9 (UniProtKB/TrEMBL) | Q6IPS9_HUMAN (UniProtKB/TrEMBL) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_009854 | Homo sapiens |
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EEF1A1 is involved in the binding of tRNA to ribosomes during protein synthesis. In fruit flies, overexpression of EEF1A1 increases longevity [0814]. Whether EEF1A1 has any role in mammalian ageing has not been determined. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
EF1A1_HUMAN | P68104 | Elongation factor 1-alpha 1 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 462 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 EF1A1_HUMAN 1 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK 462
Q6IPS9_HUMAN | Q6IPS9 | Elongation factor 1-alpha (Homo sapiens) from UniProtKB/TrEMBL Length: 462 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 Q6IPS9_HUMAN 1 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK 462
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Shepherd JC, Walldorf U, Hug P, Gehring WJ:
Fruit flies with additional expression of the elongation factor EF-1 alpha live longer.
Proc Natl Acad Sci USA. 1989; 86: 7520-1.
PubMed (ID: 2508089), PubMed Central (ID: PMC298096)
MeSH Terms: Drosophila melanogaster/genetics; Eukaryotic Initiation Factor-1/genetics - Stearns SC, Kaiser M:
The effects of enhanced expression of elongation factor EF-1 alpha on lifespan in Drosophila melanogaster. IV. A summary of three experiments.
Genetica. 1993; 91: 167-82.
PubMed (ID: 8125267)
MeSH Terms: Drosophila melanogaster/physiology; Gene Expression Regulation/physiology; Longevity; Peptide Elongation Factors/genetics - Shikama N, Ackermann R, Brack C:
Protein synthesis elongation factor EF-1 alpha expression and longevity in Drosophila melanogaster.
Proc Natl Acad Sci USA. 1994; 91: 4199-203.
PubMed (ID: 8183891), PubMed Central (ID: PMC43752)
MeSH Terms: Drosophila melanogaster/growth & development; Peptide Elongation Factors/biosynthesis - Ackermann R, Brack C:
A strong ubiquitous promoter-enhancer for development and aging of Drosophila melanogaster.
Nucleic Acids Res. 1996; 24: 2452-3.
PubMed (ID: 8710521), PubMed Central (ID: PMC145933)
MeSH Terms: Drosophila melanogaster/genetics; Enhancer Elements, Genetic; Peptide Elongation Factors/genetics; Promoter Regions, Genetic - Duttaroy A, Bourbeau D, Wang XL, Wang E:
Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha.
Exp Cell Res. 1998; 238: 168-76.
PubMed (ID: 9457069), doi:10.1006/excr.1997.3819
MeSH Terms: Apoptosis/physiology; Gene Expression Regulation; Peptide Elongation Factors/biosynthesis
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL