Gene: INSR - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | INSR | ||||||||||||||||
NCBI Gene ID | : | 3643 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | CD220 | HHF5 | INSR | INSULIN RECEPTOR | insulin receptor | IR Source: GPSDB |
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Gene Homologs | : | INSR (Bos taurus) | INSR (Canis lupus familiaris) | INSR (Gallus gallus) | INSR (Homo sapiens) | INSR (Macaca mulatta) | Insr (Mus musculus) | INSR (Pan troglodytes) | Insr (Rattus norvegicus) | insra (Danio rerio) | insrb (Danio rerio) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_004746 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Insulin receptor | Homo sapiens | P06213 (UniProtKB/Swiss-Prot) | INSR_HUMAN (UniProtKB/Swiss-Prot) | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. [ 12138094] shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, [ 16831875] shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009654 | Homo sapiens |
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INSR binds insulin (INS) and regulates energy metabolism [1108]. Evidence from model organisms, including results from fruit flies [0187] and roundworms [0539], relates INSR homologues to ageing, most likely as part of the GH1/IGF1 axis. In mice, disruption of INSR in adipose tissue extends longevity but does not appear to delay ageing [0178]. Mutations in the human INSR gene have been associated with insulin resistance [1661]. INSR could play a role in some human age-related pathologies, but it is not known whether it is a major player in human ageing. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | |||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_008229 |
|
2 | The HomoloGene homology group 20090 contains 2 genes with experimental evidence for ageing relevance (INSR - Homo sapiens | Insr - Mus musculus) and 8 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 20090 |
Sequences
INSR_HUMAN | P06213 | Insulin receptor (Homo sapiens) from UniProtKB/Swiss-Prot Length: 1382 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 INSR_HUMAN 1 MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS 1382
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Odawara M, Kadowaki T, Yamamoto R, Shibasaki Y, Tobe K, Accili D, Bevins C, Mikami Y, Matsuura N, Akanuma Y:
Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor.
Science. 1989; 245: 66-8.
PubMed (ID: 2544998)
MeSH Terms: Diabetes Mellitus, Type 2/genetics; Genes; Mutation; Protein-Tyrosine Kinases/genetics; Receptor, Insulin/genetics - Tissenbaum HA, Guarente L:
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
Nature. 2001; 410: 227-30.
PubMed (ID: 11242085), doi:10.1038/35065638
MeSH Terms: Caenorhabditis elegans Proteins; Caenorhabditis elegans/physiology; Histone Deacetylases/genetics; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Trans-Activators/genetics - Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G:
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.
Genes Dev. 2001; 15: 672-86.
PubMed (ID: 11274053), PubMed Central (ID: PMC312654), doi:10.1101/gad.867301
MeSH Terms: Caenorhabditis elegans Proteins; Caenorhabditis elegans/metabolism; Helminth Proteins/genetics; Insulin/genetics; Insulin/pharmacology; Receptor, Insulin/metabolism; Signal Transduction - Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS:
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.
Science. 2001; 292: 107-10.
PubMed (ID: 11292875), doi:10.1126/science.1057987
MeSH Terms: Aging/physiology; Carrier Proteins/genetics; Carrier Proteins/physiology; Corpora Allata/metabolism; Drosophila Proteins; Drosophila melanogaster/physiology; Longevity/physiology; Protein-Tyrosine Kinases/genetics; Protein-Tyrosine Kinases/physiology; Receptor Protein-Tyrosine Kinases - Dominici FP, Hauck S, Argentino DP, Bartke A, Turyn D:
Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice.
J Endocrinol. 2002; 173: 81-94.
PubMed (ID: 11927387)
MeSH Terms: Growth Disorders/metabolism; Insulin/metabolism; Liver/metabolism; Phosphoproteins/metabolism; Receptor, Insulin/metabolism - Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS:
A central role for JNK in obesity and insulin resistance.
Nature. 2002; 420: 333-6.
PubMed (ID: 12447443), doi:10.1038/nature01137
MeSH Terms: Insulin Resistance/physiology; Mitogen-Activated Protein Kinases/metabolism; Obesity/enzymology; Obesity/physiopathology - Tu MP, Epstein D, Tatar M:
The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico.
Aging Cell. 2002; 1: 75-80.
PubMed (ID: 12882356)
MeSH Terms: Aging/genetics; Carrier Proteins/genetics; Drosophila Proteins/genetics; Drosophila melanogaster/genetics; Intracellular Signaling Peptides and Proteins; Longevity/genetics; Mutation/genetics; Receptor, Insulin/genetics - Nakae J, Kitamura T, Kitamura Y, Biggs WH, Arden KC, Accili D:
The forkhead transcription factor Foxo1 regulates adipocyte differentiation.
Dev Cell. 2003; 4: 119-29.
PubMed (ID: 12530968)
MeSH Terms: Adipocytes/cytology; Adipocytes/metabolism; Cell Differentiation; Transcription Factors/metabolism - Blüher M, Kahn BB, Kahn CR:
Extended longevity in mice lacking the insulin receptor in adipose tissue.
Science. 2003; 299: 572-4.
PubMed (ID: 12543978), doi:10.1126/science.1078223
MeSH Terms: Adipose Tissue/anatomy & histology; Adipose Tissue/metabolism; Longevity; Receptor, Insulin/genetics; Thinness - Jünger MA, Rintelen F, Stocker H, Wasserman JD, Végh M, Radimerski T, Greenberg ME, Hafen E:
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling.
J Biol. 2003; 2: 20.
PubMed (ID: 12908874), PubMed Central (ID: PMC333403), doi:10.1186/1475-4924-2-20
MeSH Terms: Drosophila Proteins/physiology; Drosophila/cytology; Insulin/physiology; Nuclear Proteins/genetics; Signal Transduction/physiology; Transcription Factors/genetics; Transcription Factors/physiology - Liang H, Masoro EJ, Nelson JF, Strong R, McMahan CA, Richardson A:
Genetic mouse models of extended lifespan.
Exp Gerontol. 2003; 38: 1353-64.
PubMed (ID: 14698816)
MeSH Terms: Longevity/genetics; Models, Animal; Models, Genetic - Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R:
A C. elegans mutant that lives twice as long as wild type.
Nature. 1993; 366: 461-4.
PubMed (ID: 8247153), doi:10.1038/366461a0
MeSH Terms: Caenorhabditis elegans/genetics; Genes, Helminth; Longevity/genetics - Hwangbo DS, Gershman B, Gersham B, Tu MP, Palmer M, Tatar M:
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body.
Nature. 2004; 429: 562-6.
PubMed (ID: 15175753), doi:10.1038/nature02549
MeSH Terms: Brain/metabolism; Drosophila Proteins/metabolism; Drosophila melanogaster/physiology; Fat Body/metabolism; Insulin/metabolism; Longevity/physiology; Signal Transduction; Transcription Factors/metabolism - Antebi A:
Inside insulin signaling, communication is key to long life.
Sci Aging Knowledge Environ. 2004; 2004: pe25.
PubMed (ID: 15190176), doi:10.1126/sageke.2004.23.pe25
MeSH Terms: Insulin/physiology; Longevity/physiology - Jia K, Chen D, Riddle DL:
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.
Development. 2004; 131: 3897-906.
PubMed (ID: 15253933), doi:10.1242/dev.01255
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/growth & development; Insulin/metabolism; Phosphotransferases (Alcohol Group Acceptor)/metabolism; Proteins/metabolism; Signal Transduction/physiology - Quarrie JK, Riabowol KT:
Murine models of life span extension.
Sci Aging Knowledge Environ. 2004; 2004: re5.
PubMed (ID: 15295107), doi:10.1126/sageke.2004.31.re5
MeSH Terms: Aging/genetics; Longevity/genetics; Models, Animal - Mobbs CV:
Not wisely but too well: aging as a cost of neuroendocrine activity.
Sci Aging Knowledge Environ. 2004; 2004: pe33.
PubMed (ID: 15342923), doi:10.1126/sageke.2004.35.pe33
MeSH Terms: Aging/physiology; Neurosecretory Systems/metabolism - Wessells RJ, Fitzgerald E, Cypser JR, Tatar M, Bodmer R:
Insulin regulation of heart function in aging fruit flies.
Nat Genet. 2004; 36: 1275-81.
PubMed (ID: 15565107), doi:10.1038/ng1476
MeSH Terms: Aging/physiology; Drosophila Proteins/physiology; Drosophila melanogaster/physiology; Heart/physiology; Receptor Protein-Tyrosine Kinases/physiology; Signal Transduction/physiology - Kojima T, Kamei H, Aizu T, Arai Y, Takayama M, Nakazawa S, Ebihara Y, Inagaki H, Masui Y, Gondo Y, Sakaki Y, Hirose N:
Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways.
Exp Gerontol. 2004; 39: 1595-8.
PubMed (ID: 15582274), doi:10.1016/j.exger.2004.05.007
MeSH Terms: Insulin-Like Growth Factor I/genetics; Insulin/genetics; Linkage Disequilibrium; Longevity/genetics; Polymorphism, Single Nucleotide; Signal Transduction/genetics - de Magalhães JP, Cabral JA, Magalhães D:
The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging.
Genetics. 2005; 169: 265-74.
PubMed (ID: 15466429), PubMed Central (ID: PMC1448866), doi:10.1534/genetics.104.032292
MeSH Terms: Aging/physiology; Gene Expression; Genes/physiology; Mortality - Papaconstantinou J, Deford JH, Gerstner A, Hsieh CC, Boylston WH, Guigneaux MM, Flurkey K, Harrison DE:
Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice.
Mech Ageing Dev. 2005; 126: 692-704.
PubMed (ID: 15888324), doi:10.1016/j.mad.2005.01.002
MeSH Terms: Gene Expression Regulation/physiology; Insulin-Like Growth Factor I/biosynthesis; Liver/physiology; Longevity/physiology; Signal Transduction/physiology - McColl G, Vantipalli MC, Lithgow GJ:
The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span.
FASEB J. 2005; 19: 1716-8.
PubMed (ID: 16099946), PubMed Central (ID: PMC1400606), doi:10.1096/fj.04-2447fje
MeSH Terms: Antigens, Nuclear/physiology; Caenorhabditis elegans Proteins/chemistry; Caenorhabditis elegans Proteins/genetics; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Insulin/metabolism; Longevity - Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G:
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
Science. 1997; 277: 942-6.
PubMed (ID: 9252323)
MeSH Terms: Caenorhabditis elegans/genetics; Genes, Helminth; Longevity/genetics; Receptor, Insulin/genetics - Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M:
Suppression of aging in mice by the hormone Klotho.
Science. 2005; 309: 1829-33.
PubMed (ID: 16123266), PubMed Central (ID: PMC2536606), doi:10.1126/science.1112766
MeSH Terms: Aging/physiology; Longevity/physiology; Membrane Proteins/genetics; Membrane Proteins/physiology - Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, Jimenez-Ortega V, Panici JA, Bonkowski MS, Kopchick JJ, Wang Z, Bartke A:
Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart.
Exp Gerontol. 2006; 41: 417-29.
PubMed (ID: 16524678), PubMed Central (ID: PMC3082456), doi:10.1016/j.exger.2006.01.009
MeSH Terms: Aging/metabolism; Caloric Restriction; Insulin/metabolism; Myocardium/metabolism; Receptors, Somatotropin/metabolism; Signal Transduction/physiology - Baugh LR, Sternberg PW:
DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest.
Curr Biol. 2006; 16: 780-5.
PubMed (ID: 16631585), doi:10.1016/j.cub.2006.03.021
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/growth & development; Cyclin-Dependent Kinase Inhibitor Proteins/metabolism; Repressor Proteins/metabolism; Transcription Factors/physiology - Katic M, Kennedy AR, Leykin I, Norris A, McGettrick A, Gesta S, Russell SJ, Bluher M, Maratos-Flier E, Kahn CR:
Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice.
Aging Cell. 2007; 6: 827-39.
PubMed (ID: 18001293), doi:10.1111/j.1474-9726.2007.00346.x
MeSH Terms: Adipose Tissue, White/metabolism; Gene Expression; Genes, Mitochondrial/genetics; Longevity/physiology; Mitochondria/metabolism; Thinness/metabolism - Paradis S, Ruvkun G:
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.
Genes Dev. 1998; 12: 2488-98.
PubMed (ID: 9716402), PubMed Central (ID: PMC317081)
MeSH Terms: Caenorhabditis elegans Proteins; Caenorhabditis elegans/physiology; Helminth Proteins/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Phosphatidylinositol 3-Kinases/physiology; Proto-Oncogene Proteins; Receptor, Insulin/physiology; Signal Transduction; Transcription Factors/physiology - Lakowski B, Hekimi S:
The genetics of caloric restriction in Caenorhabditis elegans.
Proc Natl Acad Sci USA. 1998; 95: 13091-6.
PubMed (ID: 9789046), PubMed Central (ID: PMC23719)
MeSH Terms: Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Energy Intake/genetics; Feeding Behavior; Genes, Helminth; Mutation - Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR:
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
Cell. 1999; 96: 329-39.
PubMed (ID: 10025399)
MeSH Terms: Diabetes Mellitus, Type 2/genetics; Insulin/deficiency; Insulin/secretion; Islets of Langerhans/metabolism; Receptor, Insulin/deficiency; Receptor, Insulin/genetics; Viral Proteins - Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP:
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.
Science. 1999; 283: 1544-8.
PubMed (ID: 10066179)
MeSH Terms: Insulin/metabolism; Obesity/metabolism; Protein Tyrosine Phosphatases/genetics; Protein Tyrosine Phosphatases/metabolism - Honda Y, Honda S:
The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans.
FASEB J. 1999; 13: 1385-93.
PubMed (ID: 10428762)
MeSH Terms: Caenorhabditis elegans/physiology; Gene Expression Regulation/physiology; Longevity/genetics; Receptor, Insulin/genetics; Superoxide Dismutase/genetics - Wolkow CA, Kimura KD, Lee MS, Ruvkun G:
Regulation of C. elegans life-span by insulinlike signaling in the nervous system.
Science. 2000; 290: 147-50.
PubMed (ID: 11021802)
MeSH Terms: Aging/physiology; Caenorhabditis elegans Proteins; Caenorhabditis elegans/physiology; Neurons/physiology; Phosphatidylinositol 3-Kinases; Receptor, Insulin/metabolism; Signal Transduction
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot