Gene: POLD1 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | POLD1 | ||||||||||||||||
NCBI Gene ID | : | 5424 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | CDC2 | CDC2 homolog | CDC2 homolog (S. cerevisiae) | DNA polymerase delta catalytic subunit | DNA polymerase subunit delta p125 | POLD | POLD1 | polymerase (DNA directed), delta 1, catalytic subunit | polymerase (DNA directed), delta 1, catalytic subunit (125kD) | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | POLYMERASE (DNA-DIRECTED), DELTA 1, CATALYTIC SUBUNIT | POLYMERASE, DNA, DELTA Source: GPSDB |
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Gene Homologs | : | AGOS_AFL189W (Eremothecium gossypii) | cdc6 (Schizosaccharomyces pombe) | DNApol-delta (Drosophila melanogaster) | F10C2.4 (Caenorhabditis elegans) | KLLA0E01607g (Kluyveromyces lactis) | MGG_08071 (Magnaporthe oryzae) | NCU01192 (Neurospora crassa) | Os11g0186400 (Oryza sativa) | POL3 (Saccharomyces cerevisiae) | POLD1 (Arabidopsis thaliana) | POLD1 (Bos taurus) | POLD1 (Canis lupus familiaris) | pold1 (Danio rerio) | POLD1 (Homo sapiens) | POLD1 (Macaca mulatta) | Pold1 (Mus musculus) | POLD1 (Pan troglodytes) | Pold1 (Rattus norvegicus) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_004767 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
DNA polymerase delta catalytic subunit | Homo sapiens | P28340 (UniProtKB/Swiss-Prot) | DPOD1_HUMAN (UniProtKB/Swiss-Prot) | Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_009721 | Homo sapiens |
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POLD1 is mostly involved in DNA synthesis, and probably it also functions in DNA repair [0920]. Mice with a proofreading-deficient version of POLD1 have a higher cancer incidence [0917]. POLD1 has also been associated with WRN [0922]. There is no direct evidence linking POLD1 to human ageing, but it should be considered a suspect gene. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009385 | 1 | The HomoloGene homology group 2014 contains 1 gene with experimental evidence for ageing relevance (POLD1 - Homo sapiens) and 17 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 2014 |
Sequences
DPOD1_HUMAN | P28340 | DNA polymerase delta catalytic subunit (Homo sapiens) from UniProtKB/Swiss-Prot Length: 1107 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 DPOD1_HUMAN 1 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQSVLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRGSVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGRELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPSFAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPPEGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAHVELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQEQLLRRFGPPGPEAW 1107
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Spadari S, Focher F, Hübscher U:
Developmental activity profile of DNA polymerases delta and alpha in rat neurons suggests a coordinated in vivo function.
In Vivo. 1988; 2: 317-20.
PubMed (ID: 2979851)
MeSH Terms: Brain/growth & development; DNA Polymerase II/metabolism; DNA-Directed DNA Polymerase/metabolism; Neurons/enzymology - Raji NS, Krishna TH, Rao KS:
DNA-polymerase alpha, beta, delta and epsilon activities in isolated neuronal and astroglial cell fractions from developing and aging rat cerebral cortex.
Int J Dev Neurosci. 2002; 20: 491-6.
PubMed (ID: 12392752)
MeSH Terms: Aging/genetics; Astrocytes/enzymology; Cell Differentiation/genetics; Cerebral Cortex/enzymology; Cerebral Cortex/growth & development; DNA Repair/genetics; DNA-Directed DNA Polymerase/metabolism; Neurons/enzymology - Goldsby RE, Hays LE, Chen X, Olmsted EA, Slayton WB, Spangrude GJ, Preston BD:
High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading.
Proc Natl Acad Sci USA. 2002; 99: 15560-5.
PubMed (ID: 12429860), PubMed Central (ID: PMC137756), doi:10.1073/pnas.232340999
MeSH Terms: DNA Polymerase III/physiology; DNA Repair; Neoplasms, Experimental/genetics - Dresler SL, Gowans BJ, Robinson-Hill RM, Hunting DJ:
Involvement of DNA polymerase delta in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation.
Biochemistry. 1988; 27: 6379-83.
PubMed (ID: 3146346)
MeSH Terms: DNA Repair; DNA Replication/radiation effects; DNA-Directed DNA Polymerase/metabolism; Ultraviolet Rays - Nishida C, Reinhard P, Linn S:
DNA repair synthesis in human fibroblasts requires DNA polymerase delta.
J Biol Chem. 1988; 263: 501-10.
PubMed (ID: 3335506)
MeSH Terms: DNA Repair; DNA-Directed DNA Polymerase/metabolism - Prapurna DR, Rao KS:
DNA polymerases delta and epsilon in developing and aging rat brain.
Int J Dev Neurosci. 1997; 15: 67-73.
PubMed (ID: 9099618)
MeSH Terms: Aging/metabolism; Brain/enzymology; DNA-Directed DNA Polymerase/metabolism; Enzyme Inhibitors/pharmacology - Kamath-Loeb AS, Johansson E, Burgers PM, Loeb LA:
Functional interaction between the Werner Syndrome protein and DNA polymerase delta.
Proc Natl Acad Sci USA. 2000; 97: 4603-8.
PubMed (ID: 10781066), PubMed Central (ID: PMC18279)
MeSH Terms: DNA Helicases/chemistry; DNA Helicases/metabolism; DNA Polymerase III/chemistry; DNA Polymerase III/metabolism; DNA Replication; Werner Syndrome/genetics - Szekely AM, Chen YH, Zhang C, Oshima J, Weissman SM:
Werner protein recruits DNA polymerase delta to the nucleolus.
Proc Natl Acad Sci USA. 2000; 97: 11365-70.
PubMed (ID: 11027336), PubMed Central (ID: PMC17206), doi:10.1073/pnas.97.21.11365
MeSH Terms: Cell Nucleolus/enzymology; DNA Helicases/metabolism; DNA Polymerase III/metabolism; Werner Syndrome/metabolism - Mohaghegh P, Hickson ID:
DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.
Hum Mol Genet. 2001; 10: 741-6.
PubMed (ID: 11257107)
MeSH Terms: Adenosine Triphosphatases/deficiency; Adenosine Triphosphatases/genetics; Aging; DNA Helicases/deficiency; DNA Helicases/genetics; Genetic Predisposition to Disease; Neoplasms/enzymology; Neoplasms/genetics - Kamath-Loeb AS, Loeb LA, Johansson E, Burgers PM, Fry M:
Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence.
J Biol Chem. 2001; 276: 16439-46.
PubMed (ID: 11279038), doi:10.1074/jbc.M100253200
MeSH Terms: DNA Helicases/metabolism; DNA Polymerase III/metabolism; DNA/chemistry; DNA/genetics; Nucleic Acid Conformation; Trinucleotide Repeats; Werner Syndrome/enzymology - Shen J, Loeb LA:
Unwinding the molecular basis of the Werner syndrome.
Mech Ageing Dev. 2001; 122: 921-44.
PubMed (ID: 11348659)
MeSH Terms: DNA Helicases/physiology; DNA-Binding Proteins; Werner Syndrome/enzymology
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot