Gene: Cisd2 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Cisd2 |
NCBI Gene ID |
: |
67006 |
Species |
: |
Mus musculus |
Gene Synonyms |
: |
CDGSH iron sulfur domain 2 | CDGSH iron sulfur domain-containing protein 2 | CDGSH iron-sulfur domain-containing protein 2 | Cdgsh2 | Cisd2 | Miner1 | mitoNEET-related 1 protein | nervous system over-expressed protein 70 | nervous system overexpressed protein 70 | Noxp70 | Zcd2 | zinc finger, CDGSH-type domain 2
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP004484 (Anopheles gambiae) | CG1458 (Drosophila melanogaster) | CISD2 (Bos taurus) | cisd2 (Danio rerio) | CISD2 (Gallus gallus) | CISD2 (Homo sapiens) | Cisd2 (Mus musculus) | CISD2 (Pan troglodytes) | Cisd2 (Rattus norvegicus) | LOC100429989 (Macaca mulatta) | LOC100855477 (Canis lupus familiaris) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_004785 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
CDGSH iron-sulfur domain-containing protein 2 |
Mus musculus |
Q9CQB5 (UniProtKB/Swiss-Prot) |
CISD2_MOUSE (UniProtKB/Swiss-Prot) |
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. |
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_006289 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Cisd2 |
67006 |
|
|
Knockout mice have a shorten lifespan and exhibit signs of premature aging, including prominent eyes and protruding ears, ocular abnormalities (opaque eyes and blindness), early depigmentation of the fur, hair follicle atrophy, decreased hair density and regrowth rate, thickened dermis, significant decrease in subcutaneous adipose tissue and muscle, muscle atrophy, osteroporosis, decrease in pulmonary capacity. |
19451219 |
GenAge |
2 |
OB_006291 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Cisd2 |
67006 |
|
|
Lifespan was extended for both sexes of the Cisd2 TG mice (gain-of-function mutation) without any statistically significant sex difference. In addition, when the Cisd2 TG mice were compared to WT mice, there was no obvious phenotypic effect on body weight or body temperature, or on the measured metabolic indices, including intake of food and water and generation of urine and stool. Aging appeared to be delayed in skin (measured by hair greying and mice's capacity to repel water), muscle and neurons. Mouse mutants also displayed protection of mitochondria from age-associated damage, and reduction of the age-associated decline in mitochondrial function and whole-body energy metabolism. |
22661501 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_006292 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Cisd2 |
Mus musculus |
67006 |
Overexpression |
- |
wildtype |
yes |
|
|
|
increased |
11.70% |
|
|
|
maximum |
|
|
female |
Lifespan was extended for both sexes of the Cisd2 TG mice (gain-of-function mutation) without any statistically significant sex difference. In addition, when the Cisd2 TG mice were compared to WT mice, there was no obvious phenotypic effect on body weight or body temperature, or on the measured metabolic indices, including intake of food and water and generation of urine and stool. Aging appeared to be delayed in skin (measured by hair greying and mice's capacity to repel water), muscle and neurons. Mouse mutants also displayed protection of mitochondria from age-associated damage, and reduction of the age-associated decline in mitochondrial function and whole-body energy metabolism. |
Wu et al. |
2012 |
22661501 |
doi:10.1093/hmg/dds210 |
GenAge |
2 |
OB_006290 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Cisd2 |
Mus musculus |
67006 |
Knockout |
- |
wildtype |
yes |
|
|
|
decreased |
-15.00% |
|
|
|
maximum |
|
|
|
Knockout mice have a shorten lifespan and exhibit signs of premature aging, including prominent eyes and protruding ears, ocular abnormalities (opaque eyes and blindness), early depigmentation of the fur, hair follicle atrophy, decreased hair density and regrowth rate, thickened dermis, significant decrease in subcutaneous adipose tissue and muscle, muscle atrophy, osteroporosis, decrease in pulmonary capacity. |
Chen et al. |
2009 |
19451219 |
doi:10.1101/gad.1779509 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008255 |
|
2 |
The HomoloGene homology group 36436 contains 2 genes with experimental evidence for ageing relevance (CISD2 - Homo sapiens | Cisd2 - Mus musculus) and 9 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 36436 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Chen YF, Kao CH, Chen YT, Wang CH, Wu CY, Tsai CY, Liu FC, Yang CW, Wei YH, Hsu MT, Tsai SF, Tsai TF:
Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice.
Genes Dev. 2009; 23: 1183-94.
PubMed (ID: 19451219), PubMed Central (ID: PMC2685531), doi:10.1101/gad.1779509
MeSH Terms: Aging, Premature/physiopathology; Aging/genetics; Aging/metabolism; Carrier Proteins/metabolism; Mitochondria/metabolism; Nerve Tissue Proteins/deficiency; Nerve Tissue Proteins/metabolism
- Wu CY, Chen YF, Wang CH, Kao CH, Zhuang HW, Chen CC, Chen LK, Kirby R, Wei YH, Tsai SF, Tsai TF:
A persistent level of Cisd2 extends healthy lifespan and delays aging in mice.
Hum Mol Genet. 2012; 21: 3956-68.
PubMed (ID: 22661501), doi:10.1093/hmg/dds210
MeSH Terms: Carrier Proteins/genetics; Longevity/genetics; Nerve Tissue Proteins/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources