1 |
OB_003816 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mev-1 |
Caenorhabditis elegans |
260040 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-27.78% |
13 |
18 |
days |
median |
20 |
℃ |
|
RNAi knockdown of sdhc-1 in N2-L440 decreased lifespan approximately 28%. |
Pujol et al. |
2013 |
23555681 |
doi:10.1371/journal.pone.0059493 |
Lifespan Observations Database (ID: 5429) |
2 |
OB_001460 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mev-1 |
Caenorhabditis elegans |
260040 |
loss of function |
kn1 |
unknown |
unknown |
|
|
|
decreased |
-29.53% |
10.5 |
14.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation decreased lifespan 30%. |
Kayser et al. |
2004 |
15178135 |
doi:10.1016/j.mad.2004.04.002 |
Lifespan Observations Database (ID: 2770) |
3 |
OB_002452 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mev-1 |
Caenorhabditis elegans |
260040 |
loss of function |
kn1 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Reduced oxygen |
60% oxygen |
|
decreased |
-34.62% |
8.5 |
13 |
days |
mean |
25 |
℃ |
hermaphrodite |
Mutant mev-1 (kn1 ) lifespan is 35% shorter than wild type. Other phenotypes: Mutants are hypersensitive to raised oxygen concentrations and their lifespan decreases dramatically as oxygen concentrations increase. |
Ishii et al. |
1998 |
9716135 |
doi:10.1038/29331 |
Lifespan Observations Database (ID: 3713) |
4 |
OB_001451 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mev-1 |
Caenorhabditis elegans |
260040 |
unknown |
kn1 |
unknown |
unknown |
|
|
|
decreased |
-35.00% |
13 |
20 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi-mediated inhibition of soluble fumarate reductase differentially increases Mit mutant life span. Life-span studies were performed in duplicate and using 25 microM FuDR (n=120 worms/condition). |
Butler et al. |
2010 |
20732954 |
doi:10.1096/fj.10-162941 |
Lifespan Observations Database (ID: 2762) |
5 |
OB_001452 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
F48E8.3 |
Caenorhabditis elegans |
175751 |
RNAi knockdown |
- |
unknown |
unknown |
mev-1 |
Caenorhabditis elegans |
260040 |
unknown |
kn1 |
unknown |
unknown |
|
|
|
decreased |
-35.00% |
13 |
20 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi-mediated inhibition of soluble fumarate reductase differentially increases Mit mutant life span. Life-span studies were performed in duplicate and using 25 microM FuDR (n=120 worms/condition). |
Butler et al. |
2010 |
20732954 |
doi:10.1096/fj.10-162941 |
Lifespan Observations Database (ID: 2763) |
6 |
OB_002982 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mev-1 |
Caenorhabditis elegans |
260040 |
unknown |
kn-1 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Catechin |
200 |
micromolar |
|
|
decreased |
-42.87% |
9.66 |
16.91 |
days |
mean |
20 |
℃ |
hermaphrodite |
The flavanol catechin extended life span in C. elegans. |
Saul et al. |
2009 |
19501612 |
doi:10.1016/j.mad.2009.05.005 |
Lifespan Observations Database (ID: 4317) |
7 |
OB_002983 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mev-1 |
Caenorhabditis elegans |
260040 |
unknown |
kn-1 |
unknown |
unknown |
|
|
|
decreased |
-43.35% |
9.58 |
16.91 |
days |
mean |
20 |
℃ |
hermaphrodite |
The flavanol catechin extended life span in C. elegans. |
Saul et al. |
2009 |
19501612 |
doi:10.1016/j.mad.2009.05.005 |
Lifespan Observations Database (ID: 4318) |
8 |
OB_000974 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mev-1 |
Caenorhabditis elegans |
260040 |
unknown |
kn1 |
unknown |
unknown |
|
|
|
decreased |
-47.62% |
11 |
21 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi-mediated inhibition of soluble fumarate reductase differentially increases Mit mutant life span. |
Butler et al. |
2010 |
20732954 |
doi:10.1096/fj.10-162941 |
Lifespan Observations Database (ID: 2288) |
9 |
OB_001455 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
iejf92 |
Caenorhabditis elegans |
|
unknown |
kn1 |
unknown |
unknown |
mev-1 |
Caenorhabditis elegans |
260040 |
unknown |
kn1 |
unknown |
unknown |
|
|
|
decreased |
-47.62% |
11 |
21 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi-mediated inhibition of soluble fumarate reductase differentially increases Mit mutant life span. |
Butler et al. |
2010 |
20732954 |
doi:10.1096/fj.10-162941 |
Lifespan Observations Database (ID: 2766) |
10 |
OB_001456 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mev-1 |
Caenorhabditis elegans |
260040 |
unknown |
kn1 |
unknown |
unknown |
|
|
|
decreased |
-47.62% |
11 |
21 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi-mediated inhibition of soluble fumarate reductase differentially increases Mit mutant life span. |
Butler et al. |
2010 |
20732954 |
doi:10.1096/fj.10-162941 |
Lifespan Observations Database (ID: 2767) |
11 |
OB_001140 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
F48E8.3 |
Caenorhabditis elegans |
175751 |
RNAi knockdown |
- |
unknown |
unknown |
mev-1 |
Caenorhabditis elegans |
260040 |
unknown |
kn1 |
unknown |
unknown |
|
|
|
decreased |
-52.38% |
10 |
21 |
days |
median |
20 |
℃ |
hermaphrodite |
RNAi-mediated inhibition of soluble fumarate reductase differentially increases Mit mutant life span. |
Butler et al. |
2010 |
20732954 |
doi:10.1096/fj.10-162941 |
Lifespan Observations Database (ID: 2458) |
12 |
OB_005557 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mev-1 |
Caenorhabditis elegans |
260040 |
Mutation |
- |
wildtype |
yes |
|
|
|
decreased |
|
|
|
|
unknown |
|
|
|
Mutants are hypersensitive to raised oxygen concentrations and their lifespan decreases dramatically as oxygen concentrations increase. |
Ishii et al. |
1998 |
9716135 |
doi:10.1038/29331 |
GenAge |
13 |
OB_005558 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mev-1 |
Caenorhabditis elegans |
260040 |
Mutation |
- |
wildtype |
yes |
|
|
|
decreased |
|
|
|
|
unknown |
|
|
|
Worm mutants had a decreased lifespan. |
Kayser et al. |
2004 |
15269213 |
doi:10.1074/jbc.M403066200 |
GenAge |