Gene: vrk-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | vrk-1 | ||||||||||||||||||||||||||||
NCBI Gene ID | : | 174004 | ||||||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||||||
Gene Synonyms | : | CE02704 | CELE_F28B12.3 | F28B12.3 | F28B12.3.1 | F28B12.3.2 | F28B12.3.3 | Protein VRK-1 | tag-223 | vrk-1 | WP:CE02704 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP001933 (Anopheles gambiae) | ball (Drosophila melanogaster) | LOC794952 (Danio rerio) | vrk-1 (Caenorhabditis elegans) | VRK1 (Bos taurus) | VRK1 (Canis lupus familiaris) | vrk1 (Danio rerio) | VRK1 (Gallus gallus) | VRK1 (Homo sapiens) | VRK1 (Macaca mulatta) | Vrk1 (Mus musculus) | VRK1 (Pan troglodytes) | Vrk1 (Rattus norvegicus) | ||||||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_004902 | ||||||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Serine/threonine-protein kinase VRK1 | Caenorhabditis elegans | Q19848 (UniProtKB/Swiss-Prot) | VRK1_CAEEL (UniProtKB/Swiss-Prot) | Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation. May act through the egl-17 signaling pathway. Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line. Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation. Regulates anchor cell polarity and the timing of anchor cell invasion through the basement membranes separating vulval and somatic gonadal cells during the L3 larval stage. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_006168 | Caenorhabditis elegans |
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RNA interference decreased median lifespan by 36% in wild type animals, 54% in a daf-2 background and 12% in daf-2/daf-16 double mutants. | 18006689 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||||||||||||||||
1 | OB_004052 | Caenorhabditis elegans |
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increased | 54.00% | RNA interference decreased median lifespan by 54% in a daf-2 background. | Samuelson et al. | 2007 | 18006689 | doi:10.1101/gad.1588907 | Lifespan Observations Database (ID: 753) | ||||||||||||||||||||||||||||||||||||||
2 | OB_004051 | Caenorhabditis elegans |
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increased | 36.00% | RNA interference decreased median lifespan by 36% in wild type animals. | Samuelson et al. | 2007 | 18006689 | doi:10.1101/gad.1588907 | Lifespan Observations Database (ID: 752) | ||||||||||||||||||||||||||||||||||||||
3 | OB_001881 | Caenorhabditis elegans | N2 |
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increased | 19.05% | 17.5 | 14.7 | days | median | 25 | ℃ | hermaphrodite | A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. | Samuelson et al. | 2007 | 18006689 | doi:10.1101/gad.1588907 | Lifespan Observations Database (ID: 3193) | ||||||||||||||||||||||||||||||
4 | OB_004053 | Caenorhabditis elegans |
|
increased | 12.00% | RNA interference decreased median lifespan by 12% in daf-2/daf-16 double mutants. | Samuelson et al. | 2007 | 18006689 | doi:10.1101/gad.1588907 | Lifespan Observations Database (ID: 754) | ||||||||||||||||||||||||||||||||||||||
5 | OB_006169 | Caenorhabditis elegans |
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decreased | -36.00% | Median | RNA interference decreased median lifespan by 36% in wild type animals, 54% in a daf-2 background and 12% in daf-2/daf-16 double mutants. | Samuelson et al. | 2007 | 18006689 | doi:10.1101/gad.1588907 | GenAge | |||||||||||||||||||||||||||||||||||||
6 | OB_001721 | Caenorhabditis elegans | N2 |
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decreased | -36.05% | 9.4 | 14.7 | days | median | 25 | ℃ | hermaphrodite | A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. | Samuelson et al. | 2007 | 18006689 | doi:10.1101/gad.1588907 | Lifespan Observations Database (ID: 3049) | ||||||||||||||||||||||||||||||
7 | OB_001957 | Caenorhabditis elegans | N2 |
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decreased | -41.50% | 8.6 | 14.7 | days | median | 25 | ℃ | hermaphrodite | A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. | Samuelson et al. | 2007 | 18006689 | doi:10.1101/gad.1588907 | Lifespan Observations Database (ID: 3261) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
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1 | OB_009316 | 1 | The HomoloGene homology group 2541 contains 1 gene with experimental evidence for ageing relevance (vrk-1 - Caenorhabditis elegans) and 12 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 2541 |
Sequences
VRK1_CAEEL | Q19848 | Serine/threonine-protein kinase VRK1 (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 610 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 VRK1_CAEEL 1 MPPKKAPAKKLHELAAEVRVGHKINDISKKTFIVGKQFATGGFGRIHTCTEEGKSQQMVMKIEPSTNGPLLTEVVVFNRILKKELIESYKKKKKISWIGLPYLIANGYFTYESEKMRYMIIPKYATSLEAVRETNGGTLAMKDSLTVASCILDALEYLHESDYAHADVKAANILLEKQGVYSTAVLVDFGLAHRTTNNVDKPDKKRAHNGTCIFTSTDAHRGNNPSFRGDIEILAYNLMMWATGTLPWMALESSPEKVFDAKQKFIAGLPGTLQNVLKNESSAVVGCIASMFDISMKTNYTDKVDMGKLKKLVTDAIQKTSSDGKKTPTRQKKLAEEDKNAVTPKRSTRRLAVKEESDNKDNDEVEVKPEKKATPRKRTTRKAVEVNNDSDDNEEQYENPKSKSSRTQTKSKRAKEEDVDDEEEIIIPKSSRSRSKVQLSGEGSDVTTPSSAASTSRSRSIRLGLTSSTASSNKVAKKIEQKYKRLSMNKSSLVPVTISVASDKSPTTSTPSSSSGLRSKRKSSEDVGEGITLKTQVLITPAIKKAKTKSGISSATKASPTELRRVPGVRNFPKGRRSMIIKETSAKYKERLASRQTKPTFDDSSCSSEV 610
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Samuelson AV, Carr CE, Ruvkun G:
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
Genes Dev. 2007; 21: 2976-94.
PubMed (ID: 18006689), PubMed Central (ID: PMC2049198), doi:10.1101/gad.1588907
MeSH Terms: Caenorhabditis elegans/physiology; Genes, Helminth; Insulin-Like Growth Factor I/genetics; Mutation; Signal Transduction/physiology
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/Swiss-Prot
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed