Gene: PDPK1 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | PDPK1 | ||||||||||||||||
NCBI Gene ID | : | 5170 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | 3-phosphoinositide dependent protein kinase-1 | 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 | 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PkB kinase | PkB kinase like gene 1 | PkB-like 1 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP001471 (Anopheles gambiae) | Os01g0872800 (Oryza sativa) | pdk-1 (Caenorhabditis elegans) | Pdk1 (Drosophila melanogaster) | PDPK1 (Arabidopsis thaliana) | PDPK1 (Bos taurus) | PDPK1 (Canis lupus familiaris) | PDPK1 (Gallus gallus) | PDPK1 (Homo sapiens) | Pdpk1 (Mus musculus) | Pdpk1 (Rattus norvegicus) | pdpk1b (Danio rerio) | PDPK2 (Arabidopsis thaliana) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_004931 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
3-phosphoinositide-dependent protein kinase 1 | Homo sapiens | H0Y4Z0 (UniProtKB/TrEMBL) | H0Y4Z0_HUMAN (UniProtKB/TrEMBL) | View | |
3-phosphoinositide-dependent protein kinase 1 | Homo sapiens | O15530 (UniProtKB/Swiss-Prot) | PDPK1_HUMAN (UniProtKB/Swiss-Prot) | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_009708 | Homo sapiens |
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PDPK1 phosphorylates and activates AKT1, among other proteins, and appears to play a role in signal transduction and development, maybe by mediating the activation of AKT1 by growth factors. The PDPK1 encodes three isoforms. In roundworms, PDPK1 has been associated with signals related to development and longevity [0948]. Mice without PDPK1 die at embryonic stages, though mice with low levels of PDPK1 are viable and fertile despite a small body size [1633]. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008186 | 2 | The HomoloGene homology group 37643 contains 2 genes with experimental evidence for ageing relevance (PDPK1 - Homo sapiens | pdk-1 - Caenorhabditis elegans) and 11 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 37643 |
Sequences
H0Y4Z0_HUMAN | H0Y4Z0 | 3-phosphoinositide-dependent protein kinase 1 (Homo sapiens) from UniProtKB/TrEMBL Length: 454 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 H0Y4Z0_HUMAN 1 MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPCLTGRII 454
PDPK1_HUMAN | O15530 | 3-phosphoinositide-dependent protein kinase 1 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 556 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 PDPK1_HUMAN 1 MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ 556
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Paradis S, Ruvkun G:
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.
Genes Dev. 1998; 12: 2488-98.
PubMed (ID: 9716402), PubMed Central (ID: PMC317081)
MeSH Terms: Caenorhabditis elegans Proteins; Caenorhabditis elegans/physiology; Helminth Proteins/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Phosphatidylinositol 3-Kinases/physiology; Proto-Oncogene Proteins; Receptor, Insulin/physiology; Signal Transduction; Transcription Factors/physiology - Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G:
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
Genes Dev. 1999; 13: 1438-52.
PubMed (ID: 10364160), PubMed Central (ID: PMC316759)
MeSH Terms: Caenorhabditis elegans Proteins; Caenorhabditis elegans/enzymology; Caenorhabditis elegans/physiology; Helminth Proteins/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Protein-Serine-Threonine Kinases/metabolism; Signal Transduction - Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, Malone L, Prescott AR, Lucocq JM, Alessi DR:
Essential role of PDK1 in regulating cell size and development in mice.
EMBO J. 2002; 21: 3728-38.
PubMed (ID: 12110585), PubMed Central (ID: PMC126129), doi:10.1093/emboj/cdf387
MeSH Terms: Cell Size/physiology; Embryonic and Fetal Development/physiology; Protein-Serine-Threonine Kinases/physiology - Jünger MA, Rintelen F, Stocker H, Wasserman JD, Végh M, Radimerski T, Greenberg ME, Hafen E:
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling.
J Biol. 2003; 2: 20.
PubMed (ID: 12908874), PubMed Central (ID: PMC333403), doi:10.1186/1475-4924-2-20
MeSH Terms: Drosophila Proteins/physiology; Drosophila/cytology; Insulin/physiology; Nuclear Proteins/genetics; Signal Transduction/physiology; Transcription Factors/genetics; Transcription Factors/physiology
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL