1 |
OB_005408 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ife-2 |
Caenorhabditis elegans |
180393 |
Mutation |
- |
wildtype |
yes |
|
|
|
increased |
30.00% |
|
|
|
maximum |
|
|
|
Loss of a specific eIF4E isoform (IFE-2) that functions in somatic tissues reduces global protein synthesis, protects from oxidative stress and extends maximum lifespan by 30% in C. elegans. Lifespan extension is independent of the forkhead transcription factor DAF-16, which mediates the effects of the insulin-like signalling pathway on ageing. Furthermore, IFE-2 deficiency further extends the lifespan of long-lived age (30%) and daf (15% maximum lifespan) nematode mutants. Knockdown of ife-2 extends the lifespan (50% maximum lifespan) of glp-4(bn2) mutant animals lacking a germ line. Similarly, lack of IFE-2 enhances the long-lived phenotype of clk (30% maximum lifespan) and dietary-restricted eat mutant animals (30% maximum lifespan). Knockdown of target of rapamycin (TOR), a phosphatidylinositol kinase that controls protein synthesis in response to nutrient cues, further increases the longevity of ife-2 mutants (10-15% maximum lifespan). Depletion of other eIF4E isoforms had no effect on longevity. |
Syntichaki et al. |
2007 |
17277769 |
doi:10.1038/nature05603 |
GenAge |
2 |
OB_001653 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ife-2 |
Caenorhabditis elegans |
180393 |
loss of function |
ok306 |
unknown |
unknown |
let-363 |
Caenorhabditis elegans |
172167 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
27.08% |
24.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown of TOR/let-363 extended lifespan of ife-2(ok306) mutants by 28% relative to ife-2(ok306) mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2989) |
3 |
OB_001655 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ife-2 |
Caenorhabditis elegans |
180393 |
loss of function |
ok306 |
unknown |
unknown |
let-363 |
Caenorhabditis elegans |
172167 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
27.08% |
24.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown of TOR/let-363 extended lifespan of ife-2(ok306) mutants by 17% relative to ife-2(ok306) mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2990) |
4 |
OB_003831 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ife-2 |
Caenorhabditis elegans |
180393 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
27.00% |
|
|
|
|
|
|
|
RNA interference extended lifespan approximately 27%. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 554) |
5 |
OB_001565 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ife-2 |
Caenorhabditis elegans |
180393 |
deletion / null |
ok306 |
unknown |
unknown |
|
|
|
increased |
23.84% |
21.3 |
17.2 |
days |
mean |
25 |
℃ |
hermaphrodite |
Deletion extended lifespan of eIF4E/ife-2(ok306) mutant relative to N2 by 23%. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2904) |
6 |
OB_001651 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ife-2 |
Caenorhabditis elegans |
180393 |
loss of function |
ok306 |
unknown |
unknown |
rps-15 |
Caenorhabditis elegans |
172693 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
22.40% |
23.5 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan of ife-2(ok306) mutants by 13% relative to ife-2(ok306) mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2987) |
7 |
OB_005406 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ife-2 |
Caenorhabditis elegans |
180393 |
Mutation |
- |
wildtype |
yes |
|
|
|
increased |
20.00% |
|
|
|
maximum |
|
|
|
Loss-of-function mutation increased maximum lifespan by about 20%. It did not extend the lifespan of daf-16(RNAi) animals. TOR RNA interference further extended lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
GenAge |
8 |
OB_001650 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ife-2 |
Caenorhabditis elegans |
180393 |
loss of function |
ok306 |
unknown |
unknown |
rps-15 |
Caenorhabditis elegans |
172693 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
16.67% |
22.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan of ife-2(ok306) mutants by 14% relative to ife-2(ok306) mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2986) |
9 |
OB_001652 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ife-2 |
Caenorhabditis elegans |
180393 |
loss of function |
ok306 |
unknown |
unknown |
rsks-1 |
Caenorhabditis elegans |
176554 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
16.15% |
22.3 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown of S6K/rsks-1 extended lifespan of ife-2(ok306) mutants by 17% relative to ife-2(ok306) mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2988) |
10 |
OB_001564 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ife-2 |
Caenorhabditis elegans |
180393 |
deletion / null |
ok306 |
unknown |
unknown |
|
|
|
increased |
10.87% |
20.4 |
18.4 |
days |
mean |
25 |
℃ |
hermaphrodite |
Deletion extended lifespan of eIF4E/ife-2(ok306) mutant relative to N2 by 11%. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2903) |
11 |
OB_005409 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ife-2 |
Caenorhabditis elegans |
180393 |
RNA interference |
- |
wildtype |
yes |
|
|
|
increased |
10.00% |
|
|
|
maximum |
|
|
|
RNAi resulted in a 10% maximum lifespan extension compared to wild-type. |
Wang et al. |
2010 |
20700440 |
doi:10.1371/journal.pgen.1001048 |
GenAge |
12 |
OB_001594 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
ife-2 |
Caenorhabditis elegans |
180393 |
loss of function |
ok306 |
unknown |
unknown |
|
|
|
none |
2.33% |
17.6 |
17.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA knockdown throughout whole life of eIF4E/ife-2(ok306) decreased lifespan 15% relative to ife-2 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2930) |
13 |
OB_001592 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
ife-2 |
Caenorhabditis elegans |
180393 |
loss of function |
ok306 |
unknown |
unknown |
|
|
|
decreased |
-30.23% |
12 |
17.2 |
days |
mean |
25 |
℃ |
hermaphrodite |
RNA knockdown throughout whole life of eIF4E/ife-2(ok306) decreased lifespan 44% relative to ife-2 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2929) |