Gene: hsp-4 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | hsp-4 | ||||||||||||||||||||||||
NCBI Gene ID | : | 174203 | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Gene Synonyms | : | CE07244 | CELE_F43E2.8 | F43E2.8 | F43E2.8.1 | F43E2.8.2 | hsp-4 | hsp70d | Protein HSP-4 | WP:CE07244 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP004192 (Anopheles gambiae) | AGOS_ACR038W (Eremothecium gossypii) | bip1 (Schizosaccharomyces pombe) | Hsc70-3 (Drosophila melanogaster) | hsp-3 (Caenorhabditis elegans) | hsp-4 (Caenorhabditis elegans) | HSPA5 (Bos taurus) | HSPA5 (Canis lupus familiaris) | hspa5 (Danio rerio) | HSPA5 (Gallus gallus) | HSPA5 (Homo sapiens) | HSPA5 (Macaca mulatta) | Hspa5 (Mus musculus) | HSPA5 (Pan troglodytes) | Hspa5 (Rattus norvegicus) | KAR2 (Saccharomyces cerevisiae) | KLLA0D09559g (Kluyveromyces lactis) | MED37A (Arabidopsis thaliana) | MED37F (Arabidopsis thaliana) | MGG_02503 (Magnaporthe oryzae) | NCU03982 (Neurospora crassa) | Os02g0115900 (Oryza sativa) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_005094 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Heat shock 70 kDa protein D | Caenorhabditis elegans | P20163 (UniProtKB/Swiss-Prot) | HSP7D_CAEEL (UniProtKB/Swiss-Prot) | Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_007912 | Caenorhabditis elegans |
|
RNA interference resulted in sick, short-lived adults. | 16741121 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_003817 | Caenorhabditis elegans |
|
increased | 8.00% | RNA interference resulted in sick, short-lived adults by 8% at 25 degrees. | Olsen et al. | 2006 | 16741121 | doi:10.1126/science.1124981 | Lifespan Observations Database (ID: 542) | ||||||||||||||||||||||||
2 | OB_007913 | Caenorhabditis elegans |
|
decreased | unknown | RNA interference resulted in sick, short-lived adults. | Olsen et al. | 2006 | 16741121 | doi:10.1126/science.1124981 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
HSP7D_CAEEL | P20163 | Heat shock 70 kDa protein D (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 657 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 HSP7D_CAEEL 1 MKVFSLILIAFVANAYCDEGASTEKEEKMGTIIGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFSGDQGERLIGDAAKNQLTINPENTIFDAKRLIGRFYNEKTVQQDIKHWPFKIVDKSNKPNVEVKVGSETKQFTPEEVSAMVLTKMKQIAESYLGHEVKNAVVTVPAYFNDAQKQATKDAGSIAGLNVVRIINEPTAAAIAYGLDKKDGERNILVFDLGGGTFDVSLLTIDSGVFEVLATNGDTHLGGEDFDQRVMEYFIKLYKKKSGKDLRKDNRAVQKLRREVEKAKRALSTQHQTKIEIESLFDGEDFSETLTRAKFEELNMDLFRATLKPVQKVLEDADMKKTDVHEIVLVGGSTRIPKVQQLIKDYFNGKEPSRGINPDEAVAYGAAVQAGVIGGVENTGDVVLLDVNPLTLGIETVGGVMTKLIGRNTVIPTKKSQVFSTAADSQSAVSIVIYEGERPMVMDNHKLGNFDVTGIPPAPRGVPQIEVTFEIDVNGILHVSAEDKGTGNKNKLTITNDHNRLSPEDIERMINDADKFAADDQAQKEKVESRNELEAYAYQMKTQIADKEKLGGKLTDEDKVSIESAVERAIEWLGSNQDASTEENKEQKKELESVVQPIVSKLYSAGGQGEQASEEPSEDHDEL 657
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Olsen A, Vantipalli MC, Lithgow GJ:
Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans.
Science. 2006; 312: 1381-5.
PubMed (ID: 16741121), PubMed Central (ID: PMC2568993), doi:10.1126/science.1124981
MeSH Terms: Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/physiology; Cell Cycle Proteins/physiology; Mitosis/physiology
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/Swiss-Prot
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed