1 |
OB_001835 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
increased |
66.67% |
24.5 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3151) |
2 |
OB_008132 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
increased |
58.00% |
38 |
24 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
3 |
OB_008134 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
increased |
56.00% |
37.5 |
24 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
4 |
OB_008136 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
increased |
56.00% |
37.5 |
24 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
5 |
OB_008130 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
increased |
47.00% |
36 |
24.5 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
6 |
OB_003597 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
over-expression |
aa1-321 |
unknown |
unknown |
|
|
|
increased |
37.50% |
22 |
16 |
days |
median |
20 |
℃ |
|
Overexpressing aak-2 (aa 1321) increases lifespan by 37.5% relative to N2 control. |
Mair et al. |
2011 |
21331044 |
doi:10.1038/nature09706 |
Lifespan Observations Database (ID: 5032) |
7 |
OB_008137 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
increased |
37.00% |
23.16 |
16.89 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
8 |
OB_008135 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
increased |
35.00% |
22.53 |
16.64 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
9 |
OB_003158 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
loss of function |
ok524 |
unknown |
unknown |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad1116 |
unknown |
unknown |
|
|
|
increased |
29.50% |
25.9 |
20 |
|
mean |
20 |
℃ |
|
Mean lifespan of double mutant eat-2(ad1116); aak-2(ok524) was approximately 30% greater than N2. |
Curtis et al. |
2006 |
16626391 |
doi:10.1111/j.1474-9726.2006.00205.x |
Lifespan Observations Database (ID: 4551) |
10 |
OB_008133 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
increased |
27.00% |
21.13 |
16.65 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
11 |
OB_003602 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
over-expression |
aa1-321 |
unknown |
unknown |
|
|
|
increased |
25.00% |
20 |
16 |
days |
median |
20 |
℃ |
|
AAK-2 (aa 1321) overexpression increases wild-type lifespan approximately 25% but has no effect on worms expressing CRTC-1 (S76A, S179A). |
Mair et al. |
2011 |
21331044 |
doi:10.1038/nature09706 |
Lifespan Observations Database (ID: 5037) |
12 |
OB_008131 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
increased |
25.00% |
21.02 |
16.78 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
13 |
OB_003163 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
loss of function |
ok524 |
unknown |
unknown |
glp-1 |
Caenorhabditis elegans |
176286 |
loss of function |
or178 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
Eggs to L4 molt were maintained at 15 degrees Celsius, then moved to 20 degrees Celsius during adulthood. |
|
increased |
16.22% |
21.5 |
18.5 |
days |
mean |
20 |
℃ |
|
Mean lifespan of double mutant glp-1(or178); aak-2(ok524) was extended approximately 16% relative to N2. |
Curtis et al. |
2006 |
16626391 |
doi:10.1111/j.1474-9726.2006.00205.x |
Lifespan Observations Database (ID: 4556) |
14 |
OB_003151 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
loss of function |
ok524 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm 150 |
unknown |
unknown |
|
|
|
increased |
13.00% |
22.6 |
20 |
|
mean |
20 |
℃ |
|
Lifespan of double mutant isp-1 (qm 150); aak-2(ok524) increased by approximately 13% relative to N2. |
Curtis et al. |
2006 |
16626391 |
doi:10.1111/j.1474-9726.2006.00205.x |
Lifespan Observations Database (ID: 4545) |
15 |
OB_000528 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
12.00% |
|
|
|
|
|
|
|
Knockout aak-2(ok524) mutants have a 12% shorter lifespan. Other phenotypes: Could be a sensor that couples energy levels and insulin-like signals to lifespan. |
Apfeld et al. |
2004 |
15574588 |
doi:10.1101/gad.1255404 |
Lifespan Observations Database (ID: 178) |
16 |
OB_008080 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
RNAi knockdown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
increased |
6.00% |
38 |
36 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
17 |
OB_003155 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
loss of function |
ok524 |
unknown |
unknown |
geln3 |
Caenorhabditis elegans |
|
over-expression |
sir-2.1 |
unknown |
unknown |
|
|
|
none |
3.50% |
20.7 |
20 |
|
mean |
20 |
℃ |
|
Over-expression of geln3(sir-2.1), combined with aak-2(ok524) loss of function extended mean lifespan approximately 4% relative to N2. |
Curtis et al. |
2006 |
16626391 |
doi:10.1111/j.1474-9726.2006.00205.x |
Lifespan Observations Database (ID: 4549) |
18 |
OB_003160 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
loss of function |
ok524 |
unknown |
unknown |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad465 |
unknown |
unknown |
|
|
|
none |
3.50% |
20.7 |
20 |
|
mean |
20 |
℃ |
|
Mean lifespan of double mutant eat-2(ad465); aak-2(ok524) was approximately 3% greater than N2. |
Curtis et al. |
2006 |
16626391 |
doi:10.1111/j.1474-9726.2006.00205.x |
Lifespan Observations Database (ID: 4553) |
19 |
OB_008111 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
|
Compound Name |
Quantity |
Quantity Unit |
Butylated hydroxyanisole |
25 |
micromolar |
|
|
none |
3.00% |
23.16 |
22.53 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
20 |
OB_008110 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
Butylated hydroxyanisole |
25 |
micromolar |
|
|
none |
2.00% |
16.89 |
16.64 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
21 |
OB_008109 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
RNAi knockdown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
none |
1.00% |
21.13 |
21.02 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
22 |
OB_003153 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
loss of function |
ok524 |
unknown |
unknown |
clk-1 |
Caenorhabditis elegans |
175729 |
loss of function |
qm30 |
unknown |
unknown |
|
|
|
none |
0.00% |
20 |
20 |
|
mean |
20 |
℃ |
|
There was no significant difference in mean lifespan of double mutant clk-1(qm30); aak-2(ok524) relative to N2 lifespan. |
Curtis et al. |
2006 |
16626391 |
doi:10.1111/j.1474-9726.2006.00205.x |
Lifespan Observations Database (ID: 4547) |
23 |
OB_003603 |
Caenorhabditis elegans |
AGD466 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
over-expression |
aa1-321 |
unknown |
unknown |
|
|
|
none |
0.00% |
18 |
18 |
days |
median |
20 |
℃ |
|
AAK-2 (aa 1321) overexpression increases wild-type lifespan but has no significant effect on worms expressing CRTC-1 (S76A, S179A). |
Mair et al. |
2011 |
21331044 |
doi:10.1038/nature09706 |
Lifespan Observations Database (ID: 5038) |
24 |
OB_008081 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
Butylated hydroxyanisole |
25 |
micromolar |
|
|
none |
0.00% |
24 |
24 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
25 |
OB_008082 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
|
Compound Name |
Quantity |
Quantity Unit |
Butylated hydroxyanisole |
25 |
micromolar |
|
|
none |
0.00% |
37.5 |
37.5 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
26 |
OB_008108 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
none |
-1.00% |
16.65 |
16.78 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
27 |
OB_008079 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
none |
-2.00% |
24 |
24.5 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
28 |
OB_003149 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
loss of function |
ok524 |
unknown |
unknown |
|
|
|
decreased |
-12.00% |
17.6 |
20 |
|
mean |
20 |
℃ |
|
Lifespan of aak-2(ok524) mutant decreased by approximately 12% relative to N2. |
Curtis et al. |
2006 |
16626391 |
doi:10.1111/j.1474-9726.2006.00205.x |
Lifespan Observations Database (ID: 4543) |
29 |
OB_005374 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
Knockout |
- |
wildtype |
yes |
|
|
|
decreased |
-12.00% |
|
|
|
unknown |
|
|
|
Could be a sensor that couples energy levels and insulin-like signals to lifespan. Knockout mutants have a 12% shorter lifespan. |
Apfeld et al. |
2004 |
15574588 |
doi:10.1101/gad.1255404 |
GenAge |
30 |
OB_003161 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
loss of function |
ok524 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
Eggs to L4 molt were maintained at 15 degrees Celsius, then moved to 20 degrees Celsius during adulthood. |
|
decreased |
-13.51% |
16 |
18.5 |
|
mean |
20 |
℃ |
|
Mean lifespan of mutant aak-2(ok524) was shortened approximately 14% relative to N2. |
Curtis et al. |
2006 |
16626391 |
doi:10.1111/j.1474-9726.2006.00205.x |
Lifespan Observations Database (ID: 4554) |
31 |
OB_002834 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
deletion / null |
ok524 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Oxaloacetate |
8 |
mM |
|
|
decreased |
-15.97% |
12.1 |
14.4 |
|
mean |
20 |
℃ |
hermaphrodite |
Oxaloacetate supplementation increased lifespan in Caenorhabditis elegans. The increase was dependent on the transcription factor, FOXO DAF-16, and the energy sensor, AMP-activated protein kinase. |
Williams et al. |
2009 |
19793063 |
doi:10.1111/j.1474-9726.2009.00527.x |
Lifespan Observations Database (ID: 4122) |
32 |
OB_002833 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
deletion / null |
ok524 |
unknown |
unknown |
|
|
|
decreased |
-17.36% |
11.9 |
14.4 |
|
mean |
20 |
℃ |
hermaphrodite |
Oxaloacetate supplementation increased lifespan in Caenorhabditis elegans. The increase was dependent on the transcription factor, FOXO DAF-16, and the energy sensor, AMP-activated protein kinase. |
Williams et al. |
2009 |
19793063 |
doi:10.1111/j.1474-9726.2009.00527.x |
Lifespan Observations Database (ID: 4121) |
33 |
OB_001991 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-35.37% |
9.5 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3292) |
34 |
OB_001709 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-53.74% |
6.8 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3038) |
35 |
OB_005376 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
RNA interference |
- |
wildtype |
yes |
|
|
|
decreased |
-54.00% |
|
|
|
Median |
|
|
|
37% decrease in median lifespna in daf-2 background and 54% decrease in lifespan in a wild-type background |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
GenAge |