Gene: lbp-4 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | lbp-4 | ||||||||||||||||||||||||
NCBI Gene ID | : | 179161 | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Gene Synonyms | : | CE07641 | CELE_ZK742.5 | lbp-4 | Protein LBP-4 | WP:CE07641 | ZK742.5 | ZK742.5.1 | ZK742.5.2 Source: GPSDB |
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Gene Homologs | : | lbp-1 (Caenorhabditis elegans) | lbp-2 (Caenorhabditis elegans) | lbp-3 (Caenorhabditis elegans) | lbp-4 (Caenorhabditis elegans) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_005112 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Fatty acid-binding protein homolog 4 | Caenorhabditis elegans | Q23092 (UniProtKB/Swiss-Prot) | FABP4_CAEEL (UniProtKB/Swiss-Prot) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_005490 | Caenorhabditis elegans |
|
RNA interference resulted in decreased lifespan and earlier accumulation of lipofuscin. | 16673436 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_003849 | Caenorhabditis elegans |
|
increased | 6.00% | RNA interference resulted in 6% decreased lifespan. | Ha et al. | 2006 | 16673436 | doi:10.1002/pmic.200500395 | Lifespan Observations Database (ID: 570) | ||||||||||||||||||||||||
2 | OB_005491 | Caenorhabditis elegans |
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decreased | unknown | RNA interference resulted in decreased lifespan and earlier accumulation of lipofuscin. | Ha et al. | 2006 | 16673436 | doi:10.1002/pmic.200500395 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_008681 |
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1 | The HomoloGene homology group 116146 contains 1 gene with experimental evidence for ageing relevance (lbp-4 - Caenorhabditis elegans) and 3 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 116146 |
Sequences
FABP4_CAEEL | Q23092 | Fatty acid-binding protein homolog 4 (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 145 10 20 30 40 50 60 70 80 90 100 110 120 130 140 FABP4_CAEEL 1 MSVPDKFFGRYQLDKSENFDEFLSSKGVNWFVRQMIKLAGLTKIISQNQEAGKYNMENLTSKKNTNYQAWELGKKFEAPGLDGNQHEITFDFKDEILSEHHIRLNEPETSAETYFYTIDDQNQLVMRMENNGIVCRRWFKRVEQK 145
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Ha MK, Soo Cho J, Baik OR, Lee KH, Koo HS, Chung KY:
Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis.
Proteomics. 2006; 6: 3339-51.
PubMed (ID: 16673436), doi:10.1002/pmic.200500395
MeSH Terms: Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/physiology; Cell Aging/physiology; Endothelial Cells/physiology
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/Swiss-Prot
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed