Gene: mdh-1 - Caenorhabditis elegans(see also ageing factor AF_006654 *)
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | mdh-1 | ||||||||||||||||||||||||||||
NCBI Gene ID | : | 175936 * | ||||||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||||||
Gene Synonyms | : | CE09512 | CELE_F20H11.3 | F20H11.3 | F20H11.3.1 | F20H11.3.2 | mdh-1 | mdh-2 | Protein MDH-2 | WP:CE09512 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP001903 (Anopheles gambiae) | AGOS_ADR252W (Eremothecium gossypii) | AT1G53240.1 (Arabidopsis thaliana) | AT3G15020.1 (Arabidopsis thaliana) | KLLA0F17050g (Kluyveromyces lactis) | LOC719983 (Macaca mulatta) | mdh-1 (Caenorhabditis elegans) | MDH2 (Canis lupus familiaris) | mdh2 (Danio rerio) | Mdh2 (Drosophila melanogaster) | MDH2 (Gallus gallus) | MDH2 (Homo sapiens) | Mdh2 (Mus musculus) | MDH2 (Pan troglodytes) | Mdh2 (Rattus norvegicus) | MDH3 (Saccharomyces cerevisiae) | MGG_08835 (Magnaporthe oryzae) | NCU06211 (Neurospora crassa) | Os01g0649100 (Oryza sativa) | Os05g0574400 (Oryza sativa) | ||||||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_005143 | ||||||||||||||||||||||||||||
Download | : | XML |
*
AgeFactDB contains further genes associated with gene symbol mdh-1 and the species Caenorhabditis elegans: AF_006654
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Probable malate dehydrogenase, mitochondrial | Caenorhabditis elegans | O02640 (UniProtKB/Swiss-Prot) | MDHM_CAEEL (UniProtKB/Swiss-Prot) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_005544 | Caenorhabditis elegans |
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RNA interference decreased median lifespan by 10% in wild type animals and 16% in daf-2 mutants. | 18006689 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||||||||||||||||
1 | OB_001794 | Caenorhabditis elegans | N2 |
|
increased | 118.37% | 32.1 | 14.7 | days | median | 25 | ℃ | hermaphrodite | A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. | Samuelson et al. | 2007 | 18006689 | doi:10.1101/gad.1588907 | Lifespan Observations Database (ID: 3114) | ||||||||||||||||||||||||||||||
2 | OB_003873 | Caenorhabditis elegans |
|
increased | 16.00% | RNA interference decreased median lifespan by 16% in daf-2 mutants. | Samuelson et al. | 2007 | 18006689 | doi:10.1101/gad.1588907 | Lifespan Observations Database (ID: 592) | ||||||||||||||||||||||||||||||||||||||
3 | OB_003872 | Caenorhabditis elegans |
|
increased | 10.00% | RNA interference decreased median lifespan by 10% in wild type animals. | Samuelson et al. | 2007 | 18006689 | doi:10.1101/gad.1588907 | Lifespan Observations Database (ID: 591) | ||||||||||||||||||||||||||||||||||||||
4 | OB_005545 | Caenorhabditis elegans |
|
decreased | -10.00% | Median | RNA interference decreased median lifespan by 10% in wild type animals and 16% in daf-2 mutants. | Samuelson et al. | 2007 | 18006689 | doi:10.1101/gad.1588907 | GenAge | |||||||||||||||||||||||||||||||||||||
5 | OB_001773 | Caenorhabditis elegans | N2 |
|
decreased | -10.20% | 13.2 | 14.7 | days | median | 25 | ℃ | hermaphrodite | A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. | Samuelson et al. | 2007 | 18006689 | doi:10.1101/gad.1588907 | Lifespan Observations Database (ID: 3096) | ||||||||||||||||||||||||||||||
6 | OB_001994 | Caenorhabditis elegans | N2 |
|
decreased | -34.01% | 9.7 | 14.7 | days | median | 25 | ℃ | hermaphrodite | A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. | Samuelson et al. | 2007 | 18006689 | doi:10.1101/gad.1588907 | Lifespan Observations Database (ID: 3295) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
MDHM_CAEEL | O02640 | Probable malate dehydrogenase, mitochondrial (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 341 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 MDHM_CAEEL 1 MSLPAKTLVQAAANSGLRAVSVRHSSQAPKVALLGAAGGIGQPLGLLLKQDPLVAHLALYDVVNTPGVAADLSHIDSNAKVTAHTGPKELYAAVENADVIVIPAGVPRKPGMTRDDLFNTNAGIVRDLAAVIAKASPKALIAIITNPVNSTVPIASEVLKKAGVYDPKRVFGVTTLDVVRSQAFVSELKGHDASKTVVPVVGGHAGITIIPLLSQVKPSTKFSEEEISKLTPRIQDAGTEVVNAKAGAGSATLSMALAGARFANALVRGIKGEKNVQCAYVASDAVKGVEYFSTPVELGPNGVEKILGVGKVSAYEQKLIDASVPELNKNIAKGVAFVKGN 341
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Samuelson AV, Carr CE, Ruvkun G:
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
Genes Dev. 2007; 21: 2976-94.
PubMed (ID: 18006689), PubMed Central (ID: PMC2049198), doi:10.1101/gad.1588907
MeSH Terms: Caenorhabditis elegans/physiology; Genes, Helminth; Insulin-Like Growth Factor I/genetics; Mutation; Signal Transduction/physiology
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/Swiss-Prot
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed