Gene: ncbp-2 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | ncbp-2 | ||||||||||||||||
NCBI Gene ID | : | 184953 | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Gene Synonyms | : | cbp-20 | CE09667 | CELE_F26A3.2 | F26A3.2 | ncbp-2 | Protein NCBP-2 | WP:CE09667 Source: GPSDB |
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Gene Homologs | : | AGOS_AFL050W (Eremothecium gossypii) | CBC2 (Saccharomyces cerevisiae) | Cbp20 (Drosophila melanogaster) | KLLA0B10472g (Kluyveromyces lactis) | MGG_06296 (Magnaporthe oryzae) | ncbp-2 (Caenorhabditis elegans) | NCBP2 (Gallus gallus) | NCBP2_ANOGA (Anopheles gambiae) | NCU00210 (Neurospora crassa) | SPBC13A2.01c (Schizosaccharomyces pombe) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_005151 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Nuclear cap-binding protein subunit 2 | Caenorhabditis elegans | Q93594 (UniProtKB/Swiss-Prot) | NCBP2_CAEEL (UniProtKB/Swiss-Prot) | Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp-1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_006559 | Caenorhabditis elegans |
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decreased | -24.00% | Average | 24% mean lifespan reduction | Xue et al. | 2007 | 18059442 | doi:10.1038/msb4100189 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008247 | 1 | The HomoloGene homology group 103828 contains 1 gene with experimental evidence for ageing relevance (ncbp-2 - Caenorhabditis elegans) and 9 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 103828 |
Sequences
NCBP2_CAEEL | Q93594 | Nuclear cap-binding protein subunit 2 (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 154 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 NCBP2_CAEEL 1 MVFDPRTLDNPKEISAYRDQRYQGTVRDQETALRTSCTLYVGNLSYYTKEDQVYELFGRAGDVRRVIMGLDRFKKTPCGFCFVEYYTREDAELALQNISNTRMDDRVIRADWDAGFIEGRQYGRGKHGGQVRDEYRKDYDPERGGYNRAIAQKG 154
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Xue H, Xian B, Dong D, Xia K, Zhu S, Zhang Z, Hou L, Zhang Q, Zhang Y, Han JD:
A modular network model of aging.
Mol Syst Biol. 2007; 3: 147.
PubMed (ID: 18059442), PubMed Central (ID: PMC2174624), doi:10.1038/msb4100189
MeSH Terms: Aging/physiology; Models, Biological
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot