Gene: nhr-49 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | nhr-49 | ||||||||||||||||||||
NCBI Gene ID | : | 172839 | ||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||
Gene Synonyms | : | CE12084 | CE28943 | CE32693 | CE32694 | CELE_K10C3.6 | K10C3.6 | K10C3.6a | K10C3.6b | K10C3.6b.1 | K10C3.6b.2 | K10C3.6c | K10C3.6c.1 | K10C3.6c.2 | K10C3.6d | nhr-49 | Protein NHR-49 | WP:CE12084 | WP:CE28943 | WP:CE32693 | WP:CE32694 Source: GPSDB |
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Gene Homologs | : | |||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_005223 | ||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Nuclear hormone receptor family member nhr-49 | Caenorhabditis elegans | O45666 (UniProtKB/Swiss-Prot) | NHR49_CAEEL (UniProtKB/Swiss-Prot) | Orphan nuclear receptor. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_005621 | Caenorhabditis elegans |
|
RNA interference shortened lifespan and altered fatty acid composition. | 15719061 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_003896 | Caenorhabditis elegans |
|
increased | 58.00% | RNA interference shortened lifespan by 58%. | Van Gilst et al. | 2005 | 15719061 | doi:10.1371/journal.pbio.0030053 | Lifespan Observations Database (ID: 612) | ||||||||||||||||||||||||
2 | OB_005622 | Caenorhabditis elegans |
|
decreased | unknown | RNA interference shortened lifespan and altered fatty acid composition. | Van Gilst et al. | 2005 | 15719061 | doi:10.1371/journal.pbio.0030053 | GenAge |
Homology Analysis
no homology analysis observation available
Sequences
NHR49_CAEEL | O45666 | Nuclear hormone receptor family member nhr-49 (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 501 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 NHR49_CAEEL 1 MDYFLDASKHIQLNQIDEESSDDFMDLVDPLAEPCAVCGDKSTGTHYGVISCNGCKGFFRRTVLRDQKFTCRFNKRCVIDKNFRCACRYCRFQKCVQVGMKREAIQFERDPVGSPTSGASLNGTPFKKDRSPGYENGNSNGVGSNGMGQENMRTVPQSSSVIDALMEMEARVNQEMCNRYRRSQIFANGSGGSNGNDTDIQQGSDSGASAFAPPNRPCTTEVDLNEISRTTLLLMVEWAKTINPFMDLSMEDKIILLKNYAPQHLILMPAFRSPDTTRVCLFNNTYMTRDNNTDLNGFAAFKTSNITPRVLDEIVWPMRQLQMREQEFVCLKALAFLHPEAKGLSNSSQIMIRDARNRVLKALYAFILDQMPDDAPTRYGNILLLAPALKALTQLLIENMTLTKFFGLAEVDSLLSEFILDDINDHSTAPVSLQQHLSSPTTLPTNGVSPLNPAGSVGSVSSVSGITPTGMLSATLAAPLAIHPLQSQDSILNSEQNNHML 501
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto KR:
Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans.
PLoS Biol. 2005; 3: e53.
PubMed (ID: 15719061), PubMed Central (ID: PMC547972), doi:10.1371/journal.pbio.0030053
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/metabolism; Fatty Acids/metabolism; Receptors, Cytoplasmic and Nuclear/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot