Gene: lbp-6 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | lbp-6 | ||||||||||||||||||||||||
NCBI Gene ID | : | 172390 | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Gene Synonyms | : | CE14426 | CELE_W02D3.5 | lbp-6 | Protein LBP-6 | W02D3.5 | W02D3.5.1 | W02D3.5.2 | WP:CE14426 Source: GPSDB |
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Gene Homologs | : | FABP4 (Bos taurus) | FABP4 (Gallus gallus) | FABP4 (Homo sapiens) | FABP4 (Macaca mulatta) | Fabp4 (Mus musculus) | FABP4 (Pan troglodytes) | Fabp4 (Rattus norvegicus) | lbp-5 (Caenorhabditis elegans) | lbp-6 (Caenorhabditis elegans) | lbp-7 (Caenorhabditis elegans) | lbp-8 (Caenorhabditis elegans) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_005272 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Fatty acid-binding protein homolog 6 | Caenorhabditis elegans | O01812 (UniProtKB/Swiss-Prot) | FABP6_CAEEL (UniProtKB/Swiss-Prot) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_005492 | Caenorhabditis elegans |
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RNA interference resulted in decreased lifespan and earlier accumulation of lipofuscin. | 16673436 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_002869 | Caenorhabditis elegans | N2 |
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increased | 51.77% | 21.4 | 14.1 | days | mean | 20 | ℃ | hermaphrodite | When age-1-inhibited genes were targeted by RNA interference (RNAi) in wild-type or age-1(hx546) adults, most conferred significant oxidative- stress protection. RNAi constructs targeting two of those genes were shown previously to extend life, and RNAis targeting five novel genes were found here to increase lifespan | Ayyadevara et al. | 2009 | 19764929 | doi:10.1111/j.1474-9726.2009.00524.x | Lifespan Observations Database (ID: 4157) | ||||||||||||||||
2 | OB_005494 | Caenorhabditis elegans |
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increased | 20.00% | Average | Post developmental RNAi led to a 20% increase in mean lifespan. | Ayyadevara et al. | 2009 | 19764929 | doi:10.1111/j.1474-9726.2009.00524.x | GenAge | |||||||||||||||||||||||
3 | OB_002866 | Caenorhabditis elegans | N2 |
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increased | 13.25% | 18.8 | 16.6 | days | mean | 20 | ℃ | hermaphrodite | When age-1-inhibited genes were targeted by RNA interference (RNAi) in wild-type or age-1(hx546) adults, most conferred significant oxidative- stress protection. RNAi constructs targeting two of those genes were shown previously to extend life, and RNAis targeting five novel genes were found here to increase lifespan | Ayyadevara et al. | 2009 | 19764929 | doi:10.1111/j.1474-9726.2009.00524.x | Lifespan Observations Database (ID: 4154) | ||||||||||||||||
4 | OB_003850 | Caenorhabditis elegans |
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increased | 8.00% | RNA interference resulted in a 8% decreased lifespan and earlier accumulation of lipofuscin. | Ha et al. | 2006 | 16673436 | doi:10.1002/pmic.200500395 | Lifespan Observations Database (ID: 571) | ||||||||||||||||||||||||
5 | OB_005493 | Caenorhabditis elegans |
|
decreased | unknown | RNA interference resulted in decreased lifespan and earlier accumulation of lipofuscin. | Ha et al. | 2006 | 16673436 | doi:10.1002/pmic.200500395 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
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1 | OB_008273 | 2 | The HomoloGene homology group 36067 contains 2 genes with experimental evidence for ageing relevance (lbp-6 - Caenorhabditis elegans | lbp-7 - Caenorhabditis elegans) and 9 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 36067 |
Sequences
FABP6_CAEEL | O01812 | Fatty acid-binding protein homolog 6 (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 135 10 20 30 40 50 60 70 80 90 100 110 120 130 FABP6_CAEEL 1 MSQEFVGRWKLIHSENFEEYMKEVGVGLITRKAAANLKPTLEIKVEGDLWYSNQYSTFKNTTLSFKLGQEFDETTPDGRTVKSVVNFENGKFIHIQKKIKDSDKESIITRWLEGDKLITTLESGSVVSRREYVRE 135
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Ha MK, Soo Cho J, Baik OR, Lee KH, Koo HS, Chung KY:
Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis.
Proteomics. 2006; 6: 3339-51.
PubMed (ID: 16673436), doi:10.1002/pmic.200500395
MeSH Terms: Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/physiology; Cell Aging/physiology; Endothelial Cells/physiology - Ayyadevara S, Tazearslan C, Bharill P, Alla R, Siegel E, Shmookler Reis RJ:
Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan.
Aging Cell. 2009; 8: 706-25.
PubMed (ID: 19764929), PubMed Central (ID: PMC2917200), doi:10.1111/j.1474-9726.2009.00524.x
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/enzymology; Gene Expression Regulation; Mutation; Phosphatidylinositol 3-Kinases/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/Swiss-Prot
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed