Gene: lmn-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
lmn-1 |
NCBI Gene ID |
: |
172687 |
Species |
: |
Caenorhabditis elegans |
Gene Synonyms |
: |
CE15746 | CELE_DY3.2 | DY3.2 | DY3.2.1 | DY3.2.2 | lam-1 | Lam1 | lmn-1 | Protein LMN-1 | WP:CE15746
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP011938 (Anopheles gambiae) | Lam (Drosophila melanogaster) | lmn-1 (Caenorhabditis elegans) | LMNB1 (Bos taurus) | LMNB1 (Canis lupus familiaris) | lmnb1 (Danio rerio) | LMNB1 (Gallus gallus) | LMNB1 (Homo sapiens) | LMNB1 (Macaca mulatta) | Lmnb1 (Mus musculus) | LMNB1 (Pan troglodytes) | Lmnb1 (Rattus norvegicus) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
decreased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
4 |
|
|
|
Ageing Factor Stable ID |
: |
AF_005307 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
Lamin-1 |
Caenorhabditis elegans |
Q21443 (UniProtKB/Swiss-Prot) |
LMN1_CAEEL (UniProtKB/Swiss-Prot) |
Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans. |
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005517 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
lmn-1 |
172687 |
|
|
RNAi led to a 39% decrease in median lifespan in daf-2 background, 12% decrease in lifespan in daf-2/daf-16 double mutant background and 12% decrease in median lifespan in a wild-type background. |
18006689 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_001852 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
lmn-1 |
Caenorhabditis elegans |
172687 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
56.46% |
23 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3167) |
2 |
OB_001770 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
lmn-1 |
Caenorhabditis elegans |
172687 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-11.56% |
13 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3093) |
3 |
OB_001958 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
lmn-1 |
Caenorhabditis elegans |
172687 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-41.50% |
8.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3262) |
4 |
OB_005516 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
lmn-1 |
Caenorhabditis elegans |
172687 |
Deletion |
- |
wildtype |
yes |
|
|
|
decreased |
|
|
|
|
unknown |
|
|
|
Deletion resulted in a shortened lifespan. |
Haithcock et al. |
2005 |
16269543 |
doi:10.1073/pnas.0506955102 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_009045 |
|
2 |
The HomoloGene homology group 55912 contains 2 genes with experimental evidence for ageing relevance (LMNB1 - Homo sapiens | lmn-1 - Caenorhabditis elegans) and 10 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 55912 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Haithcock E, Dayani Y, Neufeld E, Zahand AJ, Feinstein N, Mattout A, Gruenbaum Y, Liu J:
Age-related changes of nuclear architecture in Caenorhabditis elegans.
Proc Natl Acad Sci USA. 2005; 102: 16690-5.
PubMed (ID: 16269543), PubMed Central (ID: PMC1283819), doi:10.1073/pnas.0506955102
MeSH Terms: Aging/metabolism; Caenorhabditis elegans/ultrastructure; Nuclear Lamina/ultrastructure
- Samuelson AV, Carr CE, Ruvkun G:
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
Genes Dev. 2007; 21: 2976-94.
PubMed (ID: 18006689), PubMed Central (ID: PMC2049198), doi:10.1101/gad.1588907
MeSH Terms: Caenorhabditis elegans/physiology; Genes, Helminth; Insulin-Like Growth Factor I/genetics; Mutation; Signal Transduction/physiology
Sources
Ageing-related Data Sources
Additional Data Sources