Gene: eef-2 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
eef-2 |
NCBI Gene ID |
: |
172743 |
Species |
: |
Caenorhabditis elegans |
Gene Synonyms |
: |
CE15900 | CELE_F25H5.4 | eef-2 | eft-2 | F25H5.4 | F25H5.4.1 | F25H5.4.2 | Protein EEF-2 | WP:CE15900
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP009441 (Anopheles gambiae) | AT1G56070.1 (Arabidopsis thaliana) | eef-2 (Caenorhabditis elegans) | eef2b (Danio rerio) | Ef2b (Drosophila melanogaster) | Os01g0742200 (Oryza sativa) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_005312 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
Elongation factor 2 |
Caenorhabditis elegans |
P29691 (UniProtKB/Swiss-Prot) |
EF2_CAEEL (UniProtKB/Swiss-Prot) |
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Involved in the morphogenesis of epidermal tissues. |
View |
Observations
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_009465 |
|
1 |
The HomoloGene homology group 133134 contains 1 gene with experimental evidence for ageing relevance (eef-2 - Caenorhabditis elegans) and 5 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 133134 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Dong MQ, Venable JD, Au N, Xu T, Park SK, Cociorva D, Johnson JR, Dillin A, Yates JR:
Quantitative mass spectrometry identifies insulin signaling targets in C. elegans.
Science. 2007; 317: 660-3.
PubMed (ID: 17673661), doi:10.1126/science.1139952
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/metabolism; Receptor, Insulin/metabolism; Signal Transduction
Sources
Ageing-related Data Sources
Additional Data Sources