1 |
OB_002141 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
(e1370)III |
unknown |
unknown |
pat-6 |
Caenorhabditis elegans |
176848 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
161.98% |
50.3 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased daf-2 lifespan by 22% relative to daf-2 lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3427) |
2 |
OB_005695 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
pat-6 |
Caenorhabditis elegans |
176848 |
RNA interference |
- |
wildtype |
yes |
|
|
|
increased |
60.00% |
|
|
|
Average |
|
|
|
Post developmental RNAi extended mean life span by 30-60%, depending on the background. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
GenAge |
3 |
OB_002198 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
(ad1116)II |
unknown |
unknown |
pat-6 |
Caenorhabditis elegans |
176848 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
47.92% |
28.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown had no significant effect on eat-2 mutants relative to eat-2 mutant alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3479) |
4 |
OB_002076 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
fem-1 |
Caenorhabditis elegans |
177335 |
loss of function |
(hc17)III |
unknown |
unknown |
fer-15 |
Caenorhabditis elegans |
|
loss of function |
b26 |
unknown |
unknown |
pat-6 |
Caenorhabditis elegans |
176848 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
35.94% |
26.1 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan of fer-15;fem-1 mutants by 18% relative to fer-15;fem-1 lifespan. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3369) |
5 |
OB_002040 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
pat-6 |
Caenorhabditis elegans |
176848 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
21.35% |
23.3 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA knockdown extended N2 lifespan. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3336) |
6 |
OB_005694 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
pat-6 |
Caenorhabditis elegans |
176848 |
RNA interference |
- |
wildtype |
yes |
|
|
|
increased |
21.00% |
|
|
|
Average |
|
|
|
RNA interference increased mean lifespan by 13-21%. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
GenAge |
7 |
OB_002200 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
(ad1116)II |
unknown |
unknown |
pat-6 |
Caenorhabditis elegans |
176848 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
10.94% |
21.3 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown decreased eat-2 lifespan by 25% relative to eat-2 lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3480) |
8 |
OB_002075 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
fem-1 |
Caenorhabditis elegans |
177335 |
loss of function |
(hc17)III |
unknown |
unknown |
fer-15 |
Caenorhabditis elegans |
|
loss of function |
b26 |
unknown |
unknown |
pat-6 |
Caenorhabditis elegans |
176848 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
none |
3.12% |
19.8 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan of fer-15;fem-1 mutants by 13% relative to fer-15;fem-1 lifespan. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3368) |
9 |
OB_002121 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
pat-6 |
Caenorhabditis elegans |
176848 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-23.96% |
14.6 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 16% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3409) |