Gene: Y65B4BR.5 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Y65B4BR.5 | ||||||||||||||||
NCBI Gene ID | : | 171646 | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Gene Synonyms | : | CE22740 | CE33239 | CELE_Y65B4BR.5 | Protein Y65B4BR.5 | WP:CE22740 | WP:CE33239 | Y65B4BR.5 | Y65B4BR.5a | Y65B4BR.5a.1 | Y65B4BR.5a.2 | Y65B4BR.5b Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP006766 (Anopheles gambiae) | AGOS_AER168C (Eremothecium gossypii) | AT3G49470.1 (Arabidopsis thaliana) | EGD2 (Saccharomyces cerevisiae) | egd2 (Schizosaccharomyces pombe) | KLLA0B04290g (Kluyveromyces lactis) | MGG_02660 (Magnaporthe oryzae) | NACA (Bos taurus) | NACA (Canis lupus familiaris) | NACA (Gallus gallus) | NACA (Homo sapiens) | NACA (Pan troglodytes) | Nacalpha (Drosophila melanogaster) | NCU00635 (Neurospora crassa) | Os01g0698900 (Oryza sativa) | Os03g0121700 (Oryza sativa) | Y65B4BR.5 (Caenorhabditis elegans) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_005606 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Nascent polypeptide-associated complex subunit alpha | Caenorhabditis elegans | Q86S66 (UniProtKB/Swiss-Prot) | NACA_CAEEL (UniProtKB/Swiss-Prot) | May promote appropriate targeting of ribosome-nascent polypeptide complexes. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_006245 | Caenorhabditis elegans |
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increased | 17.00% | Average | RNA interference in adulthood extended mean lifespan by 17%. | Curran et al. | 2007 | 17411345 | doi:10.1371/journal.pgen.0030056 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008227 | 2 | The HomoloGene homology group 123861 contains 2 genes with experimental evidence for ageing relevance (EGD2 - Saccharomyces cerevisiae | Y65B4BR.5 - Caenorhabditis elegans) and 15 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 123861 |
Sequences
NACA_CAEEL | Q86S66 | Nascent polypeptide-associated complex subunit alpha (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 197 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 NACA_CAEEL 1 MTGSTETRQKEVKEPQVDVSDDSDNEAVEQELTEEQRRVAEAAGLGDHIDKQAKQSRSEKKARKLFSKLGLKQVTGVSRVCIRKSKNILFVINKPDVFKSPGSDTYIIFGEAKIEDLTQHAQMSAIENLKPTREAPQLKTVEEDENEDVEFKEDSTGIEEKDIELVISQANTTRNKAIRALKEADNDIVNAIMSLTM 197
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Curran SP, Ruvkun G:
Lifespan regulation by evolutionarily conserved genes essential for viability.
PLoS Genet. 2007; 3: e56.
PubMed (ID: 17411345), PubMed Central (ID: PMC1847696), doi:10.1371/journal.pgen.0030056
MeSH Terms: Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Conserved Sequence/genetics; Evolution, Molecular; Genes, Essential; Genes, Helminth; Longevity/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot