Gene: aco-2 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | aco-2 | ||||||||||||||||||||||||
NCBI Gene ID | : | 176121 | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Gene Synonyms | : | aco-2 | CE25005 | CE30144 | CE32436 | CELE_F54H12.1 | F54H12.1 | F54H12.1a | F54H12.1b | F54H12.1c | F54H12.1c.1 | F54H12.1c.2 | F54H12.1c.3 | Protein ACO-2 | WP:CE25005 | WP:CE30144 | WP:CE32436 Source: GPSDB |
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Gene Homologs | : | aco-2 (Caenorhabditis elegans) | ACO1 (Saccharomyces cerevisiae) | ACO2 (Bos taurus) | ACO2 (Canis lupus familiaris) | aco2 (Danio rerio) | ACO2 (Gallus gallus) | ACO2 (Homo sapiens) | ACO2 (Macaca mulatta) | Aco2 (Mus musculus) | Aco2 (Rattus norvegicus) | Acon (Drosophila melanogaster) | AgaP_AGAP007852 (Anopheles gambiae) | AGOS_ADL032W (Eremothecium gossypii) | KLLA0C17314g (Kluyveromyces lactis) | MGG_03521 (Magnaporthe oryzae) | NCU02366 (Neurospora crassa) | SPAC24C9.06c (Schizosaccharomyces pombe) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_005673 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Probable aconitate hydratase, mitochondrial | Caenorhabditis elegans | P34455 (UniProtKB/Swiss-Prot) | ACON_CAEEL (UniProtKB/Swiss-Prot) | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_005709 | Caenorhabditis elegans |
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30% mean lifespan extension in daf2 background; no lifespan measurement in wt background | 17673661 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_001018 | Caenorhabditis elegans | rrf-3(pk1426) |
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increased | 19.00% | RNA interference in the rrf-3(pk1426) background leads to lifespan extension of about 19%. | Hamilton et al. | 2005 | 15998808 | doi:10.1101/gad.1308205 | Lifespan Observations Database (ID: 233) | |||||||||||||||||||||||
2 | OB_001571 | Caenorhabditis elegans | daf-16 (mgDf47); rrf-3 (pk1426) |
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increased | 15.00% | RNAi knockdown in the daf-16 (mgDf47); rrf-3 (pk1426) background increases lifespan by 15%. | Hamilton et al. | 2005 | 15998808 | doi:10.1101/gad.1308205 | Lifespan Observations Database (ID: 290) | |||||||||||||||||||||||
3 | OB_001789 | Caenorhabditis elegans | sir-2.1 (ok434); rrf-3 (pk1426) |
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increased | 13.00% | RNAi knockdown in the sir-2.1 (ok434); rrf-3 (pk1426) background increases lifespan by 13%. | Hamilton et al. | 2005 | 15998808 | doi:10.1101/gad.1308205 | Lifespan Observations Database (ID: 310) | |||||||||||||||||||||||
4 | OB_005708 | Caenorhabditis elegans |
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increased | unknown | RNA interference leads to lifespan extension. | Hamilton et al. | 2005 | 15998808 | doi:10.1101/gad.1308205 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008965 | 1 | The HomoloGene homology group 856 contains 1 gene with experimental evidence for ageing relevance (aco-2 - Caenorhabditis elegans) and 16 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 856 |
Sequences
ACON_CAEEL | P34455 | Probable aconitate hydratase, mitochondrial (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 777 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 ACON_CAEEL 1 MNSLLRLSHLAGPAHYRALHSSSSIWSKVAISKFEPKSYLPYEKLSQTVKIVKDRLKRPLTLSEKILYGHLDQPKTQDIERGVSYLRLRPDRVAMQDATAQMAMLQFISSGLPKTAVPSTIHCDHLIEAQKGGAQDLARAKDLNKEVFNFLATAGSKYGVGFWKPGSGIIHQIILENYAFPGLLLIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGIKLTGKLNGWTSAKDVILKVADILTVKGGTGAIVEYFGPGVDSISATGMGTICNMGAEIGATTSVFPYNESMYKYLEATGRKEIAEEARKYKDLLTADDGANYDQIIEINLDTLTPHVNGPFTPDLASSIDKLGENAKKNGWPLDVKVSLIGSCTNSSYEDMTRAASIAKQALDKGLKAKTIFTITPGSEQVRATIERDGLSKIFADFGGMVLANACGPCIGQWDRQDVKKGEKNTIVTSYNRNFTGRNDANPATHGFVTSPDITTAMAISGRLDFNPLTDELTAADGSKFKLQAPTGLDLPPKGYDPGEDTFQAPSGSGQVDVSPSSDRLQLLSPFDKWDGKDLEDMKILIKVTGKCTTDHISAAGPWLKYRGHLDNISNNLFLTAINADNGEMNKVKNQVTGEYGAVPATARKYKADGVRWVAIGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANPADYDKIDPSDNVSIVGLSSFAPGKPLTAIFKKTNGSKVEVTLNHTFNEQQIEWFKAGSALNRMKEVFAKSK 777
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS:
A systematic RNAi screen for longevity genes in C. elegans.
Genes Dev. 2005; 19: 1544-55.
PubMed (ID: 15998808), PubMed Central (ID: PMC1172061), doi:10.1101/gad.1308205
MeSH Terms: Caenorhabditis elegans/genetics; Longevity/genetics; RNA Interference - Dong MQ, Venable JD, Au N, Xu T, Park SK, Cociorva D, Johnson JR, Dillin A, Yates JR:
Quantitative mass spectrometry identifies insulin signaling targets in C. elegans.
Science. 2007; 317: 660-3.
PubMed (ID: 17673661), doi:10.1126/science.1139952
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/metabolism; Receptor, Insulin/metabolism; Signal Transduction
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot