1 |
OB_002545 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
increased |
266.67% |
77 |
21 |
days |
max |
25 |
℃ |
hermaphrodite |
Double mutation extended maximum lifespan 266%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3798) |
2 |
OB_002529 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
increased |
248.18% |
38.3 |
11 |
days |
mean |
25 |
℃ |
hermaphrodite |
Double mutation increased lifespan 250%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3783) |
3 |
OB_002538 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
increased |
184.00% |
71 |
25 |
days |
max |
20 |
℃ |
hermaphrodite |
Double mutation extended maximum lifespan 184%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3791) |
4 |
OB_002518 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
increased |
134.56% |
31.9 |
13.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of opt-2, also called pep-2, extends (60%) the life-extension caused by daf-2 mutations.Other phenotypes: Also results in retarded development, reduced body size and extended reproductive lifespan. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3773) |
5 |
OB_002532 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
let-363 |
Caenorhabditis elegans |
172167 |
RNAi knockdown |
- |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
increased |
43.64% |
15.8 |
11 |
days |
mean |
25 |
℃ |
hermaphrodite |
RNA knockdown of pep mutant increased lifespan 44% relative to wild type. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3786) |
6 |
OB_005665 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
pept-1 |
Caenorhabditis elegans |
180919 |
RNA interference |
- |
wildtype |
yes |
|
|
|
increased |
40.00% |
|
|
|
unknown |
|
|
|
Gene inactivation of nhx-2 by RNAi led to a loss of fat stores in the intestine and a 40% increase in longevity while double RNAi of nhx-2 and opt-2 led to 10-20% increase in longevity |
Nehrke |
2003 |
12939266 |
doi:10.1074/jbc.M307351200 |
GenAge |
7 |
OB_002546 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
increased |
23.81% |
26 |
21 |
days |
max |
25 |
℃ |
hermaphrodite |
Triple mutation extended maximum lifespan 24%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3799) |
8 |
OB_002550 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
let-363 |
Caenorhabditis elegans |
172167 |
RNAi knockdown |
- |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
increased |
9.52% |
23 |
21 |
days |
max |
25 |
℃ |
hermaphrodite |
RNA knockdown of deletion mutant increased maximum lifespan approximately 10% relative to wild type. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3801) |
9 |
OB_002517 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
none |
4.41% |
14.2 |
13.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of opt-2, also called pep-2, extends (60%) the life-extension caused by daf-2 mutations.Other phenotypes: Also results in retarded development, reduced body size and extended reproductive lifespan. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3772) |
10 |
OB_002534 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
none |
4.00% |
26 |
25 |
days |
max |
20 |
℃ |
hermaphrodite |
Mutation extended maximum lifespan 4%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3788) |
11 |
OB_002530 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
decreased |
-10.91% |
9.8 |
11 |
days |
mean |
25 |
℃ |
hermaphrodite |
Triple mutation shortened lifespan 10%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3784) |
12 |
OB_002540 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
decreased |
-14.29% |
18 |
21 |
days |
max |
25 |
℃ |
hermaphrodite |
Deletion shortened maximum lifespan 14%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3793) |
13 |
OB_002523 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
decreased |
-18.18% |
9 |
11 |
days |
mean |
25 |
℃ |
hermaphrodite |
Deletion shortens lifespan approximately 18%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3778) |
14 |
OB_002544 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
decreased |
-19.05% |
17 |
21 |
days |
max |
25 |
℃ |
hermaphrodite |
Double mutation shortened maximum lifespan 20%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3797) |
15 |
OB_002539 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
decreased |
-20.00% |
20 |
25 |
days |
max |
20 |
℃ |
hermaphrodite |
Double mutation shortened maximum lifespan 20%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3792) |
16 |
OB_002522 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
decreased |
-31.62% |
9.3 |
13.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Double mutation shortens lifespan approximately 32%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3777) |
17 |
OB_002528 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
decreased |
-32.73% |
7.4 |
11 |
days |
mean |
25 |
℃ |
hermaphrodite |
Double mutation shortens lifespan 33%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3782) |
18 |
OB_005667 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
pept-1 |
Caenorhabditis elegans |
180919 |
Deletion |
- |
wildtype |
yes |
|
|
|
increased |
|
|
|
|
unknown |
|
|
|
Deletion of pept1 (also called opt-2, pep-2) results in retarded development, reduced body size and extended reproductive lifespan. It also further extends (60%) the life-extension caused by daf-2 mutations. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
GenAge |