Gene: phb-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
phb-1 |
NCBI Gene ID |
: |
171768 |
Species |
: |
Caenorhabditis elegans |
Gene Synonyms |
: |
CE26775 | CELE_Y37E3.9 | phb-1 | Protein PHB-1 | WP:CE26775 | Y37E3.9 | Y37E3.9.1 | Y37E3.9.2
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP009323 (Anopheles gambiae) | AGOS_AFR313C (Eremothecium gossypii) | KLLA0D16302g (Kluyveromyces lactis) | l(2)37Cc (Drosophila melanogaster) | MGG_06004 (Magnaporthe oryzae) | NCU08946 (Neurospora crassa) | Os02g0580500 (Oryza sativa) | Os04g0462900 (Oryza sativa) | PHB (Bos taurus) | PHB (Canis lupus familiaris) | phb (Danio rerio) | PHB (Gallus gallus) | PHB (Homo sapiens) | PHB (Macaca mulatta) | Phb (Mus musculus) | phb-1 (Caenorhabditis elegans) | PHB1 (Saccharomyces cerevisiae) | phb1 (Schizosaccharomyces pombe) | PHB3 (Arabidopsis thaliana) | PHB4 (Arabidopsis thaliana) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenDR |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
decreased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_005733 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
Mitochondrial prohibitin complex protein 1 |
Caenorhabditis elegans |
Q9BKU4 (UniProtKB/Swiss-Prot) |
PHB1_CAEEL (UniProtKB/Swiss-Prot) |
PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells. |
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_008023 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
phb-1 |
171768 |
|
Other Ageing Factor Name |
Dietary restriction |
|
phb-1 RNAi shortens lifespan of WT, aak-2, cep-1 (p53) and jnk-1 mutants, but increase lifespan of daf-2, daf-7, daf-4, daf-11, gas-1, mev-1, isp-1, clk-1, nhr-49, fat-7, gld-1 mutants. daf-16 mutation fully suppresses exceptionally long-lifespan of via RNAi prohibitin-depleted, daf-2 mutants (19812672). |
19812672 |
GenDR |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_002267 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
phb-1 |
Caenorhabditis elegans |
171768 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-16.67% |
17 |
20.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
Prohibitin deficiency markedly extends the lifespan of dauer-defective C. elegans mutants while shortening the lifespan of otherwise wild-type animals. |
Artal-Sanz et al. |
2009 |
19812672 |
doi:10.1038/nature08466 |
Lifespan Observations Database (ID: 3541) |
2 |
OB_006568 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
phb-1 |
Caenorhabditis elegans |
171768 |
RNA interference post development |
- |
wildtype |
yes |
|
|
|
decreased |
|
|
|
|
unknown |
|
|
|
Post-embryonic RNAi knockdown of either phb-1 or phb-2 shortens the lifespan of otherwise wild-type worms |
Artal-Sanz et al. |
2009 |
19812672 |
doi:10.1038/nature08466 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008251 |
|
2 |
The HomoloGene homology group 1980 contains 2 genes with experimental evidence for ageing relevance (PHB1 - Saccharomyces cerevisiae | phb-1 - Caenorhabditis elegans) and 18 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 1980 |
Sequences
Sources
Ageing-related Data Sources
Additional Data Sources