Gene: lin-2 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
lin-2 |
NCBI Gene ID |
: |
181400 |
Species |
: |
Caenorhabditis elegans |
Gene Synonyms |
: |
CE27131 | CE27132 | CELE_F17E5.1 | F17E5.1 | F17E5.1a | F17E5.1b | lin-2 | Protein LIN-2 | WP:CE27131 | WP:CE27132
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP001683 (Anopheles gambiae) | CASK (Bos taurus) | CASK (Canis lupus familiaris) | CASK (Drosophila melanogaster) | CASK (Gallus gallus) | CASK (Homo sapiens) | CASK (Macaca mulatta) | Cask (Mus musculus) | CASK (Pan troglodytes) | Cask (Rattus norvegicus) | caskb (Danio rerio) | lin-2 (Caenorhabditis elegans) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_005741 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005508 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
lin-2 |
181400 |
|
|
lin-1 inhibits the growth of gld-1 tumors. Up to 30% reduction in mean lifespan in daf-2 and gld-1 double mutant background; no mean lifespan change in daf-2 mutants or wild-type background; no significant changes in the maximum lifespan in all backgrounds except daf-2 and gld-1 double mutant background (40% reduction). |
17934462 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_005507 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
lin-2 |
Caenorhabditis elegans |
181400 |
RNA interference |
- |
wildtype |
yes |
|
|
|
increased |
|
|
|
|
unknown |
|
|
|
RNA interference extends lifespan. |
Oh et al. |
2006 |
16380712 |
doi:10.1038/ng1723 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_009444 |
|
1 |
The HomoloGene homology group 2736 contains 1 gene with experimental evidence for ageing relevance (lin-2 - Caenorhabditis elegans) and 11 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 2736 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, Tissenbaum HA:
Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.
Nat Genet. 2006; 38: 251-7.
PubMed (ID: 16380712), doi:10.1038/ng1723
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/metabolism; Longevity/physiology; Transcription Factors/metabolism
- Pinkston-Gosse J, Kenyon C:
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans.
Nat Genet. 2007; 39: 1403-9.
PubMed (ID: 17934462), doi:10.1038/ng.2007.1
MeSH Terms: Aging/genetics; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans/genetics; Gene Expression Regulation, Developmental; Neoplasms/pathology; Transcription Factors/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources